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supp shown to increase lifespan via telomerase activation

telomeraselifespan ginkgo biloba

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#1 Logic

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Posted 24 September 2014 - 09:46 AM


"...*** extract increased endothelial progenitor-cell (EPC) numbers and functional activity...EPC numbers and activity were associated with the inhibition of EPC senescence, which involved activation of telomerase...*** extract significantly increased telomerase activity and phosphorylation of the serine/threonine protein kinase Akt, a downstream effector of phosphoinositide 3-kinase (PI3K)..."

These results are in vitro but:

"... Extracts of *** are widely used throughout the world for their purportedly beneficial effects on brain function... *** resulted in a trend toward fewer sessions to reach criterion performance as well as fewer errors. In addition, it was observed that rats chronically treated with *** lived significantly longer than vehicle-treated subjects..."

Now this info was posted here before.
You would think that everyone would be all over it, but it received almost no interest and only one reply.
So I assume that no one here is interested in this information and wont bother posting what it is....


The point I am trying to make is that everyone seems to firmly believe that telomere extension is so difficult and complicated that there is no way that something/s has already been found that works. Therefore any post that says it has, is too good to be true and thus studiously ignored.

'It sounds too good to be true so we aren't even going to look at it' is probably what the cavemen with spears said to the guy with the bow and arrow.

If this species is going to ignore posts like this
http://www.longecity...and-telomerase/
is it ready for or even deserve extended health/lifespan?

I expect no replies... :)


 


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#2 Logic

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Posted 25 September 2014 - 12:19 AM

EGb 761: ginkgo biloba extract, Ginkor.

EGb 761 [Ginkgo biloba extract EGb 761, Rökan, Tanakan, Tebonin] is a standardised extract of Ginkgo biloba leaves and has antioxidant properties as a free radical scavenger. A standardised extract of Ginkgo biloba leaves is a well defined product and contains approximately 24% flavone glycosides (primarily quercetin, kaempferol and isorhamnetin) and 6% terpene lactones (2.8-3.4% ginkgolides A, B and C, and 2.6-3.2% bilobalide). Ginkgolide B and bilobalide account for about 0.8% and 3% of the total extract, respectively. Other constituents include proanthocyanadins, glucose, rhamnose, organic acids, D-glucaric and ginkgolic acids. EGb 761 promotes vasodilation and improves blood flow through arteries, veins and capillaries. It inhibits platelet aggregation and prolongs bleeding time. EGb 761, which was originated by Dr Willmar Schwabe Pharmaceuticals (Dr Willmar Schwabe Group), has been available in Europe as a herbal extract since the early 1990s. However, products containing EGb 761 are not approved for use by the US FDA. As a dietary supplement, Nature's Way in the US distributes and markets a standardised extract of Ginkgo biloba leaves (the EGb 761 Formula) under the name Gingold Nature's Way. The French company Beaufour-Ipsen and its German subsidiary Ipsen Pharma are co-developing EGb 761 with Dr Willmar Schwabe Group. Beaufour-Ipsen (France) is developing EGb 761 as Tanakan, Dr Willmar Schwabe Pharmaceuticals (Germany) as Tebonin and Ipsen Pharma (Germany) as Rökan. Intersan was formerly developing EGb 761 in Germany, but Intersan appears to have been merged into Ipsen Pharma. However, there has been no recent development for these indications. In the UK and other European countries, the cardioprotective effects of EGb 761 in myocardial ischaemia and reperfusion are being investigated in preclinical studies. The psychological and physiological benefits of ginkgo are said to be based on its primary action of regulating neurotransmitters and exerting neuroprotective effects in the brain, protecting against or retarding nerve cell degeneration. Ginkgo also benefits vascular microcirculation by improving blood flow in small vessels and has antioxidant activity. There has been conflicting evidence about the benefits of ginkgo, e.g. the ginkgo clinical trial published in August 2002 in JAMA concluded that a leading ginkgo supplement did not produce measurable benefits for memory in healthy adults over 60, although a month earlier, another study concluded that the same ginkgo extract is effective in helping normal healthy older adults in memory and concentration. However, in December 2002, the Cochrane Collaboration, the world's most respected scientific reviewer of clinical trials in medicine, concluded that the published literature strongly supports the safety and potential benefits of ginkgo in treating memory loss and cognitive disorders associated with age- related dementia. A phase II study of EGb 761 in combination with fluorouracil is in progress in Germany in patients with pancreatic cancer. German researchers are investigating the potential of EGb 761 for the treatment of sudden deafness and tinnitus in clinical studies. EGb 761 was undergoing preclinical development for the potential treatment of diabetes in France, diabetic neuropathies in Russia, and cancer in Brazil. However, there has been no recent development for these indications. Beaufour-Ipsen has expressed the intention to license out its diabetes projects that may include EGb 761.
http://www.ncbi.nlm....pubmed/12757407



#3 Skyguy2005

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Posted 12 November 2014 - 10:23 PM

EGb 761: ginkgo biloba extract, Ginkor.

EGb 761 [Ginkgo biloba extract EGb 761, Rökan, Tanakan, Tebonin] is a standardised extract of Ginkgo biloba leaves and has antioxidant properties as a free radical scavenger. A standardised extract of Ginkgo biloba leaves is a well defined product and contains approximately 24% flavone glycosides (primarily quercetin, kaempferol and isorhamnetin) and 6% terpene lactones (2.8-3.4% ginkgolides A, B and C, and 2.6-3.2% bilobalide). Ginkgolide B and bilobalide account for about 0.8% and 3% of the total extract, respectively. Other constituents include proanthocyanadins, glucose, rhamnose, organic acids, D-glucaric and ginkgolic acids. EGb 761 promotes vasodilation and improves blood flow through arteries, veins and capillaries. It inhibits platelet aggregation and prolongs bleeding time. EGb 761, which was originated by Dr Willmar Schwabe Pharmaceuticals (Dr Willmar Schwabe Group), has been available in Europe as a herbal extract since the early 1990s. However, products containing EGb 761 are not approved for use by the US FDA. As a dietary supplement, Nature's Way in the US distributes and markets a standardised extract of Ginkgo biloba leaves (the EGb 761 Formula) under the name Gingold Nature's Way. The French company Beaufour-Ipsen and its German subsidiary Ipsen Pharma are co-developing EGb 761 with Dr Willmar Schwabe Group. Beaufour-Ipsen (France) is developing EGb 761 as Tanakan, Dr Willmar Schwabe Pharmaceuticals (Germany) as Tebonin and Ipsen Pharma (Germany) as Rökan. Intersan was formerly developing EGb 761 in Germany, but Intersan appears to have been merged into Ipsen Pharma. However, there has been no recent development for these indications. In the UK and other European countries, the cardioprotective effects of EGb 761 in myocardial ischaemia and reperfusion are being investigated in preclinical studies. The psychological and physiological benefits of ginkgo are said to be based on its primary action of regulating neurotransmitters and exerting neuroprotective effects in the brain, protecting against or retarding nerve cell degeneration. Ginkgo also benefits vascular microcirculation by improving blood flow in small vessels and has antioxidant activity. There has been conflicting evidence about the benefits of ginkgo, e.g. the ginkgo clinical trial published in August 2002 in JAMA concluded that a leading ginkgo supplement did not produce measurable benefits for memory in healthy adults over 60, although a month earlier, another study concluded that the same ginkgo extract is effective in helping normal healthy older adults in memory and concentration. However, in December 2002, the Cochrane Collaboration, the world's most respected scientific reviewer of clinical trials in medicine, concluded that the published literature strongly supports the safety and potential benefits of ginkgo in treating memory loss and cognitive disorders associated with age- related dementia. A phase II study of EGb 761 in combination with fluorouracil is in progress in Germany in patients with pancreatic cancer. German researchers are investigating the potential of EGb 761 for the treatment of sudden deafness and tinnitus in clinical studies. EGb 761 was undergoing preclinical development for the potential treatment of diabetes in France, diabetic neuropathies in Russia, and cancer in Brazil. However, there has been no recent development for these indications. Beaufour-Ipsen has expressed the intention to license out its diabetes projects that may include EGb 761.
http://www.ncbi.nlm....pubmed/12757407

 

I love Ginkgo Biloba. I would take it even if it did not extend lifespan (maybe it doesn't). Or even if it inhibited extended lifespan of some other drug!

 

There was also a study for EPC senescence activity of Resveratrol though, similar to this study for Ginkgo. I believe Ginkgo is also the longest (certainly one of them) living sexually reproducing in the world.

 


Edited by Skyguy2005, 12 November 2014 - 10:33 PM.


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#4 krillin

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Posted 13 November 2014 - 03:21 AM

In the telomerase paper, 10 mg/L did not work and 25 mg/L worked. Ginkgo is a mixture, so it's hard to convert that to a molar concentration. Let's use quercetin's molecular weight of 302: 83 microM works and 33 microM does not work. Those are both pretty unrealistic concentrations in vivo.



#5 Skyguy2005

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Posted 17 November 2014 - 03:49 PM

Hmmm. Not Telomerase but in response to "ischemia-reperfusion injury", Ginkgo Biloba protects by upregulating genes Beclin-1 and LightChain3, the same genes upregulated by Rapamycin in its protection of neurons in similar injuries:

 

http://xuebao.shsmu....act10315.shtml# (Ginkgo Biloba)

http://www.tandfonli...61#.VGoWdxZLrw0 (Rapamycin)

 

 

 

 

 



#6 Logic

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Posted 17 November 2014 - 05:37 PM

Rats got a dose of between 50mg/kg and 200mg/kg in this study where a significantly longer lifespan was noted.
http://www.sciencedi...031938497004642

If you convert this to a human dosage as shown below you get between 8.1mg/kg and 32.4mg/kg
hhttp://www.longecity...animal-studies/

That works out at between 567mg and 2268mg for the average person of 70kg.

#7 krillin

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Posted 18 November 2014 - 02:38 AM

Rats got a dose of between 50mg/kg and 200mg/kg in this study where a significantly longer lifespan was noted.
http://www.sciencedi...031938497004642

If you convert this to a human dosage as shown below you get between 8.1mg/kg and 32.4mg/kg
hhttp://www.longecity...animal-studies/

That works out at between 567mg and 2268mg for the average person of 70kg.

 

Maximum lifespan was 37 months vs 32 months for the controls. In other experiments that I've found with Fischer 344 rats, maximum control lifespans were 30-35 months, so this ginkgo result looks legit.



#8 Logic

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Posted 18 November 2014 - 06:09 PM

Maximum lifespan was 37 months vs 32 months for the controls. In other experiments that I've found with Fischer 344 rats, maximum control lifespans were 30-35 months, so this ginkgo result looks legit.


Yep, and it seems that telomeres can turn of pro aging genes elsewhere in the chromosome!

"...when a telomere is long, the endcap can form a loop with the chromosome that brings the telomere close to genes previously considered too far away to be regulated by telomere length. Once the telomere and the distant genes on the same chromosome are close to each other, the telomere can generally switch those genes off..."
http://www.longecity...ene-regulation/

#9 corb

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Posted 18 November 2014 - 06:28 PM

Yep, and it seems that telomeres can turn of pro aging genes

 

Where in the article did you get that they are PRO AGING GENES?!
The hell?!

 

The jumps some of you people make while reading an abstract are terrifying to me and I'm not even a scientist, I can't even imagine what the reaction would be of someone who actually does the research if he has the bad luck to stumble upon this forum some day.

 

What the article said is the telomere affects the pattern of expression of the genes. When the telomere is shortened the genes don't have that regulation mechanism anymore.



#10 Logic

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Posted 18 November 2014 - 07:07 PM

 

Yep, and it seems that telomeres can turn of pro aging genes

 
Where in the article did you get that they are PRO AGING GENES?!
The hell?!
 
The jumps some of you people make while reading an abstract are terrifying to me and I'm not even a scientist, I can't even imagine what the reaction would be of someone who actually does the research if he has the bad luck to stumble upon this forum some day.
 
What the article said is the telomere affects the pattern of expression of the genes. When the telomere is shortened the genes don't have that regulation mechanism anymore.

 

 

From the same article:
"...Researchers] found that the length of the endcaps of DNA, called telomeres, form loops that determine whether certain genes are turned off when young and become activated later in life, thereby contributing to aging and disease. "Our results suggest a potential novel mechanism for how the length of telomeres may silence genes early in life and then contribute to their activation later in life when telomeres are progressively shortened. This is a new way of gene regulation that is controlled by telomere length..."

 

If my 'jump' is too big for you; you need to learn to jump a little.  Start with small jumps.  :)

 

Jokes aside:  The genes affected in this manner may well be necessary adaptions to survive with the a lot of AGEs, toxic metals or whatever, but they may just as easily be part of an aging program designed to encourage genetic diversity or whatever.

 

One thing we can agree on is that taking Gingko is most probably a good idea?



#11 corb

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Posted 18 November 2014 - 07:38 PM

You're misreading the sentence.

If you read the whole article they talk about how the lack of regulation contributes to aging and disease, not these 3 specific genes.

 

even before the telomeres shorten to the critical length that damages the DNA, the slow erosion in length has an effect on the cell’s regulation of genes that potentially contributes to aging and the onset of disease.

 

Also

 

 

The researchers were able to identify three genes whose expression patterns are altered by telomere length

So it's not even like these genes are completely silent, but the pattern of activation is changed when the telomeres are too short.

 

Read the whole article and don't jump to conclusions. And even better, wait for a pubmed publication and not for news articles written by a personal assistant or students.

As for ginko, I'm on the fence.


Edited by corb, 18 November 2014 - 07:56 PM.






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