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Animis, Science-Based Formulas

omniscienti animis

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⌛⇒ MITOMOUSE has been fully funded!

#1 Mind

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Posted 30 October 2014 - 04:49 PM


This thread is sponsored by Animis. It can be used for promotion or informal interaction with existing or potential customers. Animis is free to delete any of their own contributions from this thread at their sole discretion, but cannot edit the content of a contribution by another user. LongeCity is not affiliated with Animis in any way and does not endorse or vouch for the safety of its products or services. LongeCity provides, at its discretion, this thread to Animis in grateful acknowledgement for a donation made to LongeCity. This thread is not, and must not be used by anyone, including Animis, as a means of conducting business, recording transactions or serving official notices or otherwise be relied on in any way. LongeCity may withdraw access to this thread, or remove this thread at its sole discretion at any time for any reason. Animis may decide to render this thread inaccessible by visitors at any time or remove, but not alter, posts made by others in this thread. With the exception of an express permission to advertise in this thread, the LongeCity User Agreement (Bylaw A) applies as normal in this thread.


Edited by Mind, 09 December 2014 - 07:48 PM.


#2 Innovator

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Posted 31 October 2014 - 08:54 PM

Animis is a unique line of dietary supplements. Whose ultimate goal is to formulate the most effective health care and cosmetic products ever released for the retail market. All products are based on science and designed with the sole intent of making the daily lives of others easier.




Our first product, Omniscienti by Animis, is the most potent cognitive enhancing product currently available on the market!

Omniscienti Label Two.jpg

 

Product Description

Those disciplined in the art of health and fitness often strive toward never letting anything hold them back from perfection. Without knowing any limits, these individuals never accept “NO” as an answer. Though, living in a cutthroat, hypercompetitive world brings fierce competition. For the next in line is waiting to take your place if you falter. Yet, with the enhancement of one's cognitive ability, one is able to strategically break through any obstacles faced along the journey set ahead of them! Providing those who obtain it that extra mental edge above their peers.

Omniscienti by Animis is the most potent cognitive enhancer ever made for the optimization of mental stamina and reversal of age-related cognitive decline. Users will experience an increase in focus, memory, motivation, and an overall heightened sense of awareness; colors will seem brighter, and sounds will sound clearer, almost instantly.

Brief Background

The central nervous system consists of a network of neurons that are able to use chemical and electrical signaling to effectively communicate to one another. These signals allow for the central nervous system to receive inputs from our surroundings and appropriately think, plan and respond. The frontal lobe of the brain is one region that receives neuronal signals and is critical to one’s ability to make decisions, move, as well as having important implications in learning and memory. By utilizing the motor, premotor, prefrontal cortex and correlating regions, the frontal cortex is able to effectively control fine movement, working memory, behavior, planning, and abstract reasoning.

One of the main afferent projections to the frontal lobe come from the temporal lobe. The temporal lobe consists of the amygdala, limbic cortex and hippocampal formation. Unlike the frontal lobe the temporal lobe has been linked to things like vision, hearing, emotion and long term memory. Regulation of the glutamate transporters are vital to the temporal lobes ability to perform its function. A transporter known for hosting the main excitatory neurotransmitter within the brain, glutamate, that plays key roles in synaptic plasticity, learning, memory, and neuronal regulation . Deficits within this network have been linked to visual, auditory, sensory disturbances and neurodegenerative diseases.





 

Ingredients

Galantamine

For thousands of years, ancient Greek mythology has told tales of Omniscienti’s main ingredient, Galantamine. Derived from the plant Galanthus caucasicus, it was once known to be responsible for Odysseus’ keen brilliance. Currently, it is known for its ability to slow the progression of memory impairments associated with Alzheimer's, and effectively reduce symptoms. The way Galantamine does this by its ability to inhibit acetylcholinesterase, an enzyme associated with the breakdown of ACh within the synaptic cleft, and potentiate Ach receptors. This mechanism of action, effectively allows Galantamine to increase the flow of blood to the frontal lobe as well as other regions of the brain, and potentiate the ACh receptors, which play a vital role in learning capacity, attention span, memory formation, neuro-protection, and plasticity. In addition, Galantamine has recently been discovered to increase insulin-like growth factor 2 within the hippocampus; promoting cell growth, survival, and migration within a region critical to new memory formation. The use of Galantamine also has the ability to increase one’s overall sensory perception as well as helping to provide a much deeper and longer sleep.

Coluracetam

The second primary ingredient in Omniscienti is Coluracetam . One of its roles is to act to enhance high-affinity choline uptake. By doing this it effectively increases the uptake of choline and synthesis of Acetylcholine within the synapse. This cognitive enhancer not only aids learning and memory, but also assists with Galantamine’s mechanism of action in a synergistic way. Coluracetam has also been shown to prevent glutamate cytotoxicity, making it helpful in fighting neurodegenerative diseases, and regulating our sensory relay system. It also has the ability to potentiate AMPA receptors for glutamate, which is essential to the formation of new memories and synaptic plasticity. This potential is linked with the medial temporal projections within the temporal lobe, an area that is critical in the formation of both declarative and long term memories. This, provides the potential to create long term improvements in the ability to form and retrieve memories, which will allow for an overall increase in both cognition and decision making.

Centrophenoxine

Centrophenoxine has been used for many years for the reversal of age-related cognitive decline. It is structurally similar to DMAE and can act as a source of choline. It is also known as a powerful anti-oxidant with the ability to rid the body of many unwanted toxins, such as lipofuscin that build up as we age. Centrophenoxine also has the ability to increase the amount of glucose uptake within the CNS as well as being a potent booster of RNA and protein synthesis, making it a potent neuro-protector and cognitive protectant. Centrophenoxines mechinism of action, leads to an overall increase in memory and cognition, in addition to its many neuroprotective properties.








Omniscienti, by Animis, utilizes a synergistic mechanism of action; its’ unique blend of high potency ingredients are able to provide users with an enhanced cognitive experience that can comprehensively take you to the next level.

This is only a brief overview of the most potent cognitive enhancer on the market. Some information within the above write up was not self discovered; this information has not been directly cited . If you would like to see this potentially available aforementioned information or any other potential references that may exist, but might have been left uncited. Please, send a request to the email below.


Last name of people that deserve credit for their work:

TBA


Edited by Innovator, 15 March 2015 - 08:20 PM.

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#3 niner

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Posted 01 November 2014 - 02:01 AM

This is only a brief overview of the most potent cognitive enhancer on the market. Some information within the above write up was not self discovered; this information has not been directly cited . If you would like to see this potentially available aforementioned information or any other potential references that may exist, but might have been left uncited. Please, send a request to the email below.


Last name of people that deserve credit for their work:

TBA


I don't get this. Why not just cite the references and credit the people here and now? Do you not know what/who they are at this point in time?

Edited by Innovator, 16 December 2014 - 07:48 PM.


⌛⇒ MITOMOUSE has been fully funded!

#4 Innovator

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Posted 01 November 2014 - 03:02 AM



This section was added after the write up was written, and we've been so busy that we haven't had a chance to post up all the names. Will try to get to it this weekend.


Edited by Innovator, 17 December 2014 - 10:03 PM.


#5 Yunasa

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Posted 01 November 2014 - 06:28 PM

awesome product, keep it up Animis! vouch for ya!

Edited by Innovator, 16 December 2014 - 07:39 PM.

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#6 Vastmandana

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Posted 30 November 2014 - 08:13 AM

FYI, their webpage http://Animis.org

Edited by Innovator, 16 December 2014 - 07:57 PM.


#7 Innovator

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Posted 30 November 2014 - 09:01 AM

Animis will be launching another product by the end of next month. I'll have more information about the product for you guys in about two week.

Edited by Innovator, 16 December 2014 - 09:10 PM.

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#8 Area-1255

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Posted 01 December 2014 - 05:35 PM

Animis will be launching another product by the end of next month. I'll have more information about the product for you guys in about two week.

Awesome, great to hear it!

Edited by Innovator, 16 December 2014 - 09:11 PM.

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#9 strider

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Posted 09 December 2014 - 01:13 AM

Reached out to the manufacturer, but did not recieve a response. Has been about 2 weeks now.

Edited by Innovator, 16 December 2014 - 08:04 PM.


⌛⇒ MITOMOUSE has been fully funded!

#10 Innovator

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Posted 09 December 2014 - 01:26 AM

The rights to Omniscienti is currently owned by different management, which is probably why you didn't get a response. Please pm me and we can discuss things further.

Edited by Innovator, 16 December 2014 - 09:11 PM.

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⌛⇒ MITOMOUSE has been fully funded!

#11 Innovator

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Posted 15 March 2015 - 04:25 AM

Wanted to let you guys know about another product that we just launched the other week, called Cordis!

 

Cordis Label.jpg

 

Cardiovascular disorders are currently the leading cause of mortality worldwide. Maintenance of a healthy cardiovascular system is pivotal to longevity in addition to keeping a healthy mind and body. Cordis by Animis is the most potent cardiovascular support formula currently available on the market. With the utilization of a synergistic blend of natural herbs formulated in Cordis, each ingredient potentiates the pharmacokinetic effects of the other. Making the therapeutic effect of the formula more potent than that obtained from any individual compound. Users of this powerful formula will experience a reduction in blood pressure, lipids, plaque buildup, and improved liver function.

 

Salviae Miltiorrhizae

Elevated levels of cholesterol and blood pressure are two major contributors of atherosclerosis and cardiovascular disease [01]. Salviae Miltiorrhizae has been used in traditional chinese medicine, for more than a millennium, for the treatment of blood disorders. Major components of salviae miltiorrhizae, include salvianolic acid & tanshinoate. Salvianolic acid B and Tanshinoate II are considered the two active component known for the management of circulatory disorders [02][03]. Salviae Miltiorrhizae extract has been shown to increase the export of total cholesterol and bile acid in the liver, while reducing LDL-cholesterol and increasing HDL-cholesterol in humans [04][05]. Tanshinoate IIA  is one of the many active components responsible for lowering LDL, threw its ability to inhibit LDL oxidation [06][07][08]. Tanshinoate also acts to upregulate superoxide dismutase activity and  eNOS phosphorylation, making it a powerful antioxidant and increaser of NO production [09][10].  Tanshinone IIA is a potent cardioprotective compound, that is able to regulate various transcription factors, ion channels, kinases, growth factor, inflammatory mediators, and more [11]. Acting to limit hypertrophy, improve heart function and strength by decreasing oxidative stress [12][14][13][15].

 

Salvianolic acid B protective therapeutic effects are due to its ability to act as a potent antioxidant/reactive oxygen species, anti-fibrotic agent, and an inhibitor of inflammation. Additionally, Salvianolic acid B is able to act as inhibitor of ACE, reducing the conversion of angiotensin I to angiotensin II and lowering blood pressure [16]. Tanshinoate IIA like Salvianolic acid B is able to indirectly reduce the production of angiotensin II. In addition Tanshinoate IIA is able to reduce the accumulation of cholesterol by macrophages, vary smooth muscle migration and proliferation. As well as reduce the ratio of thromboxane b2 to 6-keto prostaglandin f1α, leading to an improvement in our blood coagulation system [17]. As a side note Tanshinoate IIA has also been found to act as a powerful anti-cancer by its ability to trigger apoptosis through P53 activation among other mechanisms [18][19]. Additionally it has been shown to improve renal dysfunction by its interaction with angiotensin II, transforming growth factor β1 and collagen IV, as well as inducing apoptosis of hepatic stellate cells, reducing the effects of liver fibrosis, in rats [20][21]. Overall Tanshinone II is seen to be a very potent natural cardioprotective with its ability to dilate coronary arteries, lower blood pressure and lipids, protect from ischemic injury, act as a anti-inflammatory, antiplatelet, antithrombotic, antiarrhythmic, anticoagulant, and reverse myocardial hypertrophy [22][23][24][25][26].

 

Panax notoginseng

Ginseng is widely known for it restorative and healing properties. Panax Notoginseng has specifically been shown to have protective effects against cardiovascular disease, liver fibrosis and hepatotoxicity [27][28][29]. Primarily through the effects of its various constituents that have been shown to provide antioxidation, decreased platelet adhesion, vasomotor control and improved lipid profiles. Additionally it has been shown to enhance physical performance during endurance activity in humans [30]. This is primarily due to high levels of radical scavenging antioxidants and saponins that exhibit anti-inflammatory, vasodilating, anti-fatigue and the ability to act as a central nervous system stimulant [31][32]. Panax notoginseng may also be able to provide cardiovascular protection through various pharmacological mechanisms that improve microcirculation, regulate lipids, reducing arrhythmia, and has been shown to normalize blood pressure by restoring it to normal levels in individuals with both high and low blood pressure [33][34][35]. It has also shown to act as an antioxidant against atherogenesis [36]. For spanions of Panax Notoginseng have been found to have antihyperlipidemic and atherosclerotic effects [37][38][39][40]. These atherosclerotic effects are especially prominent when used in conjunction with Salvia Miltiorrhiza [41]. Additionally It has also been shown to be beneficial in protecting against tissue damage, have antihypertensive effects and may be a novel therapy for heart failure, as well as acting as a powerful antioxidant by its ability to significantly increase both superoxide dismutase and glutathione peroxidase activity [43][44][45][46]. By protecting cardiac muscle from ischemic and reperfusion injuries [47]. Research has also shown notoginseng to inhibit platelet aggregation and have preventive effects for thrombosis in vivo [48][49][50].

 

Pueraria Lobata

Pueraria Lobata has been used in conjunction with Salviae miltiorrhizae traditionally. Studies have shown that the two herbs work synergistically and additively, leading to improved vascular function in coronary patients [51][52][53]. Studies have demonstrated it to have anti-hypertension, anti-thrombosis, cholesterol lowering effects, and when used in conjunction with Salvia Miltiorrhiza is able to lower low-density lipoprotein and total cholesterol levels in human subjects [54][55][56][57][58]. Additionally, Puerinin has been shown to have protective effects against liver fibrosis, providing reduced oxidation, inflammation, of the liver, as well as protective effects against liver fibrosis and blood pressure [59][60][61][62].

 

Natural Borneol

Natural Borneol is utilized to increase the pharmacokinetic effects of the formula, particullary offering a significant 1.3-1.6 fold increase in effects of the saponins of notoginseng, as well as increasing the intestinal absorption and effects of the constituents of Salvia Miltiorrhiza [63][64][65]. In addition it helps improve oral bioavailability for the entire herbal formula [66].

 

[01] Beckerman, J. (2014, May 26).

Atherosclerosis: Causes, Symptoms, Tests, and Treatment - WebMD.

Retrieved November 19, 2014, from http://www.webmd.com/heart-disease/what-is-atherosclerosis

 

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Salvianolic acid B, an aqueous component of danshen (Salvia miltiorrhiza), relaxes rat coronary

artery by inhibition of calcium channels.

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[03] Chan, P., Liu, I.M., Li, Y.X., Yu, W.J., Cheng, J.T., 2009.

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The Complex Regulation of Tanshinone IIA in Rats with Hypertension-Induced Left Ventricular Hypertrophy

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[12] Yang P, Jia YH, Li J, Li LJ, Zhou FH (2010)

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[13] Chan P, Liu JC, Lin LJ, Chen PY, Cheng TH, et al. (2011)

Tanshinone IIA Inhibits Angiotensin II-Induced Cell Proliferation in Rat Cardiac Fibroblasts. Am J Chin Med 39: 381–394 doi:10.1142/S0192415X11008890. PubMed: 21476213.

 

[14] Zhang Y, Zhang L, Chu W, Wang B, Zhang J, et al. (2010)

Tanshinone IIA Inhibits miR-1 Expression through p38 MAPK Signal Pathway in Post-infarction Rat Cardiomyocytes.

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[15] Tan X, Li J, Wang X, Chen N, Cai B et al.. (2011)

Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Cal-cineurin/Nfatc3 Pathway. Int J Biol Sci 7: 383–389. PubMed: 21494433.

 

[16] ]D.G. Kang, H. Oh, H.T. Chung, H.S. Lee

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[17] Journal of Geriatric Cardiology March 2009 Vol 6 No 2

 

[18] Z. Zhang, et al.

Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding

Biochem. Pharmacol., 78 (2009), pp. 1316–1322

 

[19]Yong Zhang 1, Peixin Jiang 1, Min Ye 2, Sung-Hoon Kim 3, Cheng Jiang 1,* and Junxuan Lü

Tanshinones: Sources, Pharmacokinetics and Anti-Cancer Activities

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[20] Y.M. Ahn, S.K. Kim, S.H. Lee, S.Y. Ahn, S.W. Kang, J.H. Chung, S.D. Kim, B.C. Lee

Renoprotective effect of Tanshinone IIA an active component of Salvia miltiorrhiza, on rats with chronic kidney disease

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[21] X.H. Che, E.J. Park, Y.Z. Zhao, W.H. Kim, D.H. Sohn

Tanshinone II A induces apoptosis and S phase cell cycle arrest in activated rat hepatic stellate cells

Basic Clin. Pharmacol. Toxicol., 106 (2010), pp. 30–37

 

[22] M. T. Zhang, Y. H. Qian, and A. Q. Tang,

“Research progress of pharmacologic actions of Tanshinone II A,”

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“Tanshinone IIA: a promising natural cardioprotective agent,”

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“Cardiovascular effects of tanshinone II A and its mechanism research progress,”

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[25] X. H. Chen,

“Clinical analysis of tan II A on the cardiovascular effects,”

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[27]W.H. Park, S.K. Lee, C.H. Kim

A Korean herbal medicine, Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats

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[28] C.F. Lin, K.L. Wang, R.S.C. Wu, T.C. Huang, C.F. Liu

Protection by hot water extract of Panax notoginseng on chronic ethanol-induced hepatotoxicity

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[29] L.X. Li, Z.C. Wang, Z.H. Huang, Y.M. Zhang, J.X. Wei

Effects of Panax notoginseng saponins on acute cerebral ischemia

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[30] Liang MT1, Podolka TD, Chuang WJ.

Panax notoginseng supplementation enhances physical performance during endurance exercise.

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[31] Chang Ho Lee , Jong-Hoon Kim

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[35] M. Yan,

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et al.

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P.C., Woo, K.S., 2009.

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[52] David Wing-Shing Cheung, Chi-ManKoon, Chun-Fai Ng, Ping-Chung Leung,

Kwok-Pui Fung, SimonKar-SingPoon, ClaraBik-SanLau,

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atherogenic events:

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[53] Xia Wang, Xue Xu, Weiyang Tao, Yan Li, Yonghua Wang, and Ling Yang

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Applications to Cardiovascular Disease

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[54] Kwok T, Leung PC, Lam C, Ho S, Wong CK, Cheng KF, Chook P.

A randomized placebo controlled trial of an innovative herbal formula in the prevention of atherosclerosis in postmenopausal women with borderline hypercholesterolemia.

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