LONGECITY

I recently had genetic testing done through 23andMe.  I got the analysis from Promethease, but I am totally lost.  I am trying to see if I can get any clues about my issues.  I see references on the forum to COMT and various other factors, but I don't see them listed on the report.  Is there something in particular that I should be looking for?

I was also thinking about getting neurotransmitter testing done, but I've heard that it's not accurate.  I think it's done through urinalysis.  Is it worth trying?

I just wish that I could get some hints about what is wrong with me.  I have horrible concentration, can't focus, have no motivation, am obsessed with aging, have an extreme fear of death, minor social anxiety, and OCD related problems.  When I was taking ADHD medication for what my PDoc called "executive function deficits," all of these issues were resolved.  Unfortunately, I am really scared about taking stimulants long-term.

I've tried so many supplements, and nothing has worked: Oxiracetam, B Vitamins, Magnesium, L-Tyrosine, L-Theanine, Vinpocetine, L-Glutamine, 5-HTP, L-Tryptophan, Ashwagandha, Choline (caused extreme depression), Inositol, SAM-E, and others.

I'd recommend taking Methyl B-12.. dissolved under the tongue.. As well as MethylPro Folate... You might want to read about those.. Some have a bad gene and can not process Methyl well.. which is essential.  

Also it would not hurt to be tested for lead and mercury poison..

Noopept supplement might be useful too.. I think it is rather mild and has positive influence.  

I'm in a similar boat myself, actually. Just did some 23andme + promethease testing done, and found out quite a bit about my genetics.

I'm finding it extremely difficult to use the results tho'! Basically, what I wanted to find, where the specific mutations that have been given the MOST COMMON association with ADHD, and what variants I have, and which ones that are likely to cause my issues.

I have ADHD-PI with comorbid issues of anxiety, coordination, and mathematics. The coordination and mathematics weren't likely to yield any results that would be useful for my treatment-planning, but I had hoped to get useful info on my neuro-transmitters, and my neuro-chemical receptors.

I wanted to figure out the EXACT, super-ACCURATE nature of my ADHD-pathology. But I'm not sure this test is enough...

Basically, the question is, do I have one of the more common mutations - the DRD4 dopamine -receptor mutation, or do I have some other mutations? Exactly WHICH parts of my brain should I target?

We want accuracy, so we don't get side-effects, because they suck.

So, how does one use ones genetic data to get more accurate treatment?

Chris, if you want to look at the methylation issues I recommend skimming through this report.

http://www.vsan.org/...ary_sheet_1.pdf

Dr Yasko has done a lot of work in this field, not much of it has been peer reviewed.

From the skimming I have done treating methylation takes a long time. Pick a few major potential issues and target them with therapies. See if you notice a difference in six months time.

I started Methyl B-12, adenosocobalamin, and Methy folate. It has worked very, very well with some caveats. Took time to get the dosage right, required a lot of extra potassium at first (otherwise I'd get horrible anxiety). I also sometimes add tmg, d-riboside and other supplements.

My 23andME showed Homozygous a1298c, another homozygous MTHFR mutation, and also MTRR (B-12 recycling). It's been life changing, for me. Granted, only about 3 months now, but I've never gone this long before and note felt depressed and totally without energy.

The problem with the current test of 23&Me is, that Your current epigenetic state isnt measured.

This test is for now too expensive and afaik only used in clinical trials.

Also in regards of damage (stroke, denervation) or other alterations (dont know.. phosporylation & etc ?) this test isnt able to reflect this.

Just an FYI for those who used 23andMe. The company is bankrupt.