14 replies to this topic

[stolpioni]

I read on this page:

 

http://www.braintrop...ootropic-stack/

 

That taking Sulbutiamine together with SSRI could be dangerous.

I just bought a box of 100 200mg Sulbutiamine capsules and I'm currently on 50mg's of Zoloft (Sertraline) every day.

 

Is it dangerous for me to take Sulbutiamine? And why? (I thought Sulbutiamine affected dopamine, not serotonin).

[pedr0vsky]

I did sulbutiamine with cymbalta for a long time, never had a problem...

[stolpioni]

Thanks for that.

 

However, one person having a particular outcome doesn't mean that outcome will be the same

for the next. Anyone else have some information?

[FW900]

Sulbutiamine doesn't act on serotonin. There is no reason to assume that it would be contraindicated with SSRIs.

 

The article you linked is just some knucklehead who has a blog and no sources to backup his claims. I wouldn't trust the information on it again in the future.

[stolpioni]

Sulbutiamine doesn't act on serotonin. There is no reason to assume that it would be contraindicated with SSRIs.

 

The article you linked is just some knucklehead who has a blog and no sources to backup his claims. I wouldn't trust the information on it again in the future.

 

Ok. But apparently you shouldn't take dopamine-drugs on SSRI either. For example, according to drugs.com, amphetamine is a MAJOR interaction with

Zoloft and may cause serotonin syndrome:

 

http://www.drugs.com...-2057-1348.html

 

Wtf?

[stolpioni]

Friendly bump.

[macropsia]

I've heard of much worse things being coprescribed. Desensitization from long-term use is probably a greater danger than acute toxicity. Sulbutiamine is a freaking high availability form of thiamin. Large and initial doses of sulb. can seem significant, but so can large initial doses of other nutramines. Bears little comparison to traditional stimulants.

[Gorthaur]

 

Sulbutiamine doesn't act on serotonin. There is no reason to assume that it would be contraindicated with SSRIs.

 

The article you linked is just some knucklehead who has a blog and no sources to backup his claims. I wouldn't trust the information on it again in the future.

 

Ok. But apparently you shouldn't take dopamine-drugs on SSRI either. For example, according to drugs.com, amphetamine is a MAJOR interaction with

Zoloft and may cause serotonin syndrome:

 

http://www.drugs.com...-2057-1348.html

 

Wtf?

 

 

That's just as bogus as the claim that sulbutiamine and SSRIs are dangerous. There are likely hundreds of thousands of people who take amphetamine and an SSRI on a daily basis. Drugs.com will tell you that practically any two drugs which have any effect at all on serotonin can cause serotonin syndrome. In practice, serotonin syndrome is incredibly rare, and it usually takes substantial amounts of a combination of SSRIs, serotonin agonists, serotonin precursors, serotonin releasers, dissociatives, etc. in order to trigger it. I have personally experienced serotonin syndrome on a combination of zoloft and DXM, and I ended up perfectly fine with no need for medical attention, but I would not do it again. Drugs.com also told me that I would get serotonin syndrome combining sumatriptan (a serotonin agonist) with zoloft, but I did so many times without issue. I would recommend using a variety of websites, user experiences, as well as a pharmacist, in order to find out about drug interactions.

[Ark]

Most people would he fine, IMHO.

[maximum411]

I believe Zoloft is one of the SSRIs that is also a dopamine reuptake inhibitor.

[Gorthaur]

I believe Zoloft is one of the SSRIs that is also a dopamine reuptake inhibitor.

 

Only to a very tiny degree. It's not pharmacologically significant.

[maximum411]

Not necessarily:

 

http://medind.nic.in...aat13i2p435.pdf

 

http://www.ncbi.nlm....pubmed/12236626

[Noopho]

 

Sulbutiamine doesn't act on serotonin. There is no reason to assume that it would be contraindicated with SSRIs.

 

The article you linked is just some knucklehead who has a blog and no sources to backup his claims. I wouldn't trust the information on it again in the future.

 

Ok. But apparently you shouldn't take dopamine-drugs on SSRI either. For example, according to drugs.com, amphetamine is a MAJOR interaction with

Zoloft and may cause serotonin syndrome:

 

http://www.drugs.com...-2057-1348.html

 

Wtf?

 

 

Thats because Amphetamine, although primarily desired effects come from changes in dopamine level, it does have some effect on serotonin. Besides isnt ampetamine an MAO inhibitor which could cause problems with SSRI's.

 

One thing that would concern me though would be that SSRI's are mainly prescribed as antidepressants so sulbutiamine probably wouldn't be the best of supplements to take in combination just off the known mood changing effects and change in the ability to sleep as easy, I think the negative effects would outweigh the positives ones if nothing else.

[gatornoot]

I don't see why Sulbutiamine would have any interaction with SSRIs. It's not an MAOI as far as I know, nor is it a serotonin precursor. According to Wikipedia "The administration of sulbutiamine potentiates cholinergic activity in the hippocampus. It also potentiates glutamatergic activity in the prefrontal cortex through a reduction in the density of kainate glutamate receptors, which may occur in response to a modulation of intrasynaptic glutamate." So it potentiates cholinergic and glutamatergic transmission, as well as dopaminergic transmission through an increase of D1 receptor density, but there's nothing here about potentiating serotonergic transmission.

[VITAcure.me]

There are some side effects to SSRI's, and they are not for everyone. And mixed with other substances, they can have unexpected outcomes. SSRI's may of course help if serotonin is low. According to Walsh Research Research Institute, about 38% of depressives have lower than normal levels of serotonin, and that is why they tend to get depressed. In this case, SSRI's may help but still have side effects. In this case, other alternatives like nutritive support for underlying imbalances causing the problem can be at least as effective. Given to the wrong people, however, SSRI's can have fatal consequences. Also, read the PDF "A Proposal for Prevention of School Shootings" (by William J. Walsh)- not directly related to this article of course but... (can be found on Google).