2 replies to this topic

[tfor]

If for example you've already tried a SSRI and then you think about trying another one with a similar

receptor affinity profile then would this even make sense?

If for example drug A failed and drug B has an even weaker receptor affinity for the same receptors then does this

mean that drug B will also fail? Is it basically all down to numbers?

[FW900]

A lower Ki value means a stronger binding affinity.

[Flex]

Afaik:

You can compensate the lower affinity by increasing the dose.

but not the dissoziation from the receptor like in the case of neuroleptics:

quentiapine can therefore never be the same as haldol