9 replies to this topic

[MikeGreo]

Well I was initially excited when I read about research that AMPK activators reverse aging and extend lifespan. But then I found out that AMPK over-activation causes Alzheimer. LEF has recently just released an new product AMPK activator. But I guess we should steer clear of it if we don't want to risk getting Alzheimers. 

 

What if someone is already taking metformin, and wanted to also buy this product AMPK activator for its added benefit, Would that be unwise?

[MikeGreo]

References:

http://pipeline.cora...imers_worse.php

http://gradworks.umi...98/3498134.html

[Dolph]

To call that misleading is an understatement by quite a margin. Just search pubmed for AMPK + Alzheimer's and you'll come up with literally thousends of papers showing the possible ADVANTAGES of AMPK activation. Including AMPK activation through metformin...

[tunt01]

I would only be concerned with a situation of very high, chronic AMPK activation.  In a pulsatile fashion, it should be fine.

[mikela]

I would only be concerned with a situation of very high, chronic AMPK activation.  In a pulsatile fashion, it should be fine.

 

How often should it be taken (pulsed) in your view?

[tunt01]

 

I would only be concerned with a situation of very high, chronic AMPK activation.  In a pulsatile fashion, it should be fine.

 

How often should it be taken (pulsed) in your view?

 

 

It would depend on your daily circadian rhythm.  I don't know the pharma kinetics of that supplement.  Ideally, I think I would want AMPK upregulated about 1-1.5 hours after a meal and 1 hour before a meal.  I guess what I'm trying to say is to take it away from meals, as if it were like exercise.

[BobbyDick]

Best and safest AMPK agonists are saturated fatty acids.

[osris]

The connection between AMPK and Alzheimer’s is often misunderstood. I understand the concern, but the idea that AMPK activators automatically cause Alzheimer’s is a bit misleading. Over-activation only risky in stressed or diseased neurons. In a healthy brain, mild activation from supplements or metformin is generally protective, supporting energy balance, autophagy, and mitochondrial health. So combining metformin with a mild AMPK activator isn’t inherently dangerous—but with stronger activators, caution and moderation are the watch-words.

[pepsseeker618]

personally i'd take the alzheimer's worry with a grain of salt since most of that stuff comes from cell studies at doses way higher than what anyone actually runs. i've been on glp-1 agonists for over a year which bump ampk indirectly, and my bloodwork and cognition have only improved. the long term data on metformin users points the same direction, so i'm not losing sleep over it

[MikeDC]

Sulforaphane activate NRF2/GSTA4 to clear 4-HNE and rejuvenate cells and tissues.
It can also activate AMPK. The existing AMPK activators are
Not potent and have many side effects.

https://pmc.ncbi.nlm...les/PMC8806682/