LONGECITY

The October 2008 issue of LEF magazine just arrived in my mailbox. Wouldn't you know it, LEF is now selling 50 mg pyridoxamine caps. Thank goodness someone is making it again for sale in the US. First I have to finish my 6 months supply of Pyridoxall.

That brings up the question of the best dosing for benfotiamine and pyridoxamine in conjunction with the other B vitamins. Anyone want to comment on that?

Stephen

Edited by mustardseed41, 09 September 2008 - 09:52 PM.

Thank goodness someone is making it again for sale in the US

Too bad its LEF :(

I've always found LEF to have good quality but sometimes at a high price point, and they do have some unique products like mitochondrial energy optimizer and bio curcumin.

With LEF starting to sell this, others will probably pick it up too. It beats trying to source it from Asia and sending it out for testing yourself.

Stephen

I've always found LEF to have good quality but sometimes at a high price point, and they do have some unique products like mitochondrial energy optimizer and bio curcumin.

With LEF starting to sell this, others will probably pick it up too. It beats trying to source it from Asia and sending it out for testing yourself.

Stephen

Well I guess that is true. The price point and quality issues when some of thier products were tested disturbs me.

I've always found LEF to have good quality but sometimes at a high price point ... With LEF starting to sell this, others will probably pick it up too. It beats trying to source it from Asia and sending it out for testing yourself.

Well I guess that is true. The price point and quality issues when some of thier products were tested disturbs me.

I would strongly advise against the use of bulk PM material unless you're willing to have it HPLCed yourself; moreover, I not only have a generalized confidence in LEF's quality, but can specifically vouch for it in this particular case. See this post on the subject.

Thanks for the post Michael. Any thoughts on what safe levels of PM and P5P are -- are these additive? I see that I get 100 mg of P5P from my ortho-core. The National Academy of Sciences has 100 mg/day as the safe upper limit for people 19 and older, which apparently is very conservative.

Stephen

Thanks for the post Michael. Any thoughts on what safe levels of PM and P5P are -- are these additive? I see that I get 100 mg of P5P from my ortho-core. The National Academy of Sciences has 100 mg/day as the safe upper limit for people 19 and older, which apparently is very conservative.

You can read the Institute of Medicine's reasoning for setting a No-Observed-Adverse-Effect Level (NOAEL) of 200 mg/day and a Lowest-Observed-Adverse-Effect Level (LOAEL) of 500 mg/day for pyridoxine; the Upper Limit (UL) is set as half of the NOAEL (to account for population variation).

It is, in my judgement, far, far more important for a healthy life extensionist to avoid doing hirself harm than to gamble in hopes of extra benefits: there would be little more bitter than to wind up with (in this case) nerve damage short-term -- and who knows what (autonomic neuropathy, leading to loss of proper control of the heart or other essential functions) in the long term -- in a bid to extend one's life. The human studies seem to show a benefits at 50 mg of PM taken twice daily, and it's not clear that 250 mg BID was any better. Building up gradually to somewhere at or below the NOAEL for total B6 intake from all sources (pyridoxine in regular multis and many other formulas, plus any PM and P5P ) seems sound, monitoring oneself carefully for any signs of neuropathy (numbness, ataxia). Pyridoxine HCl has a molecular weight of 205.64, vs 247.14 for P5P, so you may have a little more wiggle room with the mg dose of P5P, esp as their vitamin activity per se is similar on a molar basis -- but I'm not sure that this applies to large doses where the passive absorption mechanism kicks in, since not only vitamin activity, but also toxicity, are likely mediated by P5P. If high-dose P5P leads to disproportionately high P5P concentrations at the nerves, it might conceivably be somewhat more toxic on a molar basis, balancing the above reasoning out. (See why I wish there were more studies??).

Relative to my Sep 6 2008 post, time has told......NephroGenex has re-appeared. They have a new website and a current Phase II clinical trial of Pyridorin(pyridoxamine ) in process.

There is still nothing more that I can find from the FDA on the status of pyridoxamine. It is very interesting that they continue to equate pyridoxamine with vitamin B6 in many places in their own literature.

peteinpok

Anti aging systems is now selling Pyridoxamine. ( again )
http://www.antiaging...ource=YMExpress

Anti aging systems is now selling Pyridoxamine. ( again )
http://www.antiaging...ource=YMExpress

LifeLink is selling it for much lower price per mg:
http://www.lifelinkn...cts/PrimAGE.asp