4 replies to this topic

[Groundhog Day]

I've been having several neurological symptoms so I asked my doctor for this test and it came back around 200. Lab range, 5-50 mcg/L.


My doctor (not a good one) said there is nothing to worry about even though I have a host of symptoms and am actually being evaluated for ALS since I developed constant muscle twitches last Spring.

I’ve looked around and seen this a bit now, there appear to be 2 subgroups: 1) people who supplement with a b6 at low, standard or high doses, even people who take as little as what is in a multi-vitamin. The people in this group cease supplementing and it appears their levels slowly normalize.

I am in the 2nd group... the group of people that are not supplementing with any B6, yet have elevated levels. The one thing I can find in common is that all appear to have neurological symptoms and issues.

The only B vitamins I have supplemented with in the last 6 months: I took 2 mega doses, 20k mcg of b12 to try and improve my neuropathy and lower homocysteine an I occasionally take 1000mg niacinamide. No B6.

I have seen one study with autistic children showing elevated B6 serum levels when no supplements were taken. I do not have autism nor am I child.

I have read that B6 has to be converted in the liver to pyridoxal form and that requires B2, riboflavin, so should I consider supplementing b2?

I will be researching this much more and try to find a solution, but if anyone has any insight, it would be appreciated.

 

 

 

 

[ta5]

Interesting problem. My first thought was to supplement with all the other B Vitamins except B6. Before you do that, I would want to get a wider range of tests and see what else is out of range, especially the other B vitamins. Then, try and get everything you can in line. 

 

I imagine you've had other tests, and the B6 was one of many. Was anything else out of range? 

[Groundhog Day]

In terms of vitamins, Vitamin D has been chronically low, hard to keep up. But I just had the 23andme done and it shows a couple of defective D receptors and some research has recommended taking sage/rosemary to enhance so I have started doing that.

 

Serum B12 was normal.

I've heard that methylmalonic acid in the urine is the best test for b12 status. I had 0.49 mmol/mol and the lab range is < 3.60.

Plasma folate level is normal.

 

BUN and Creatinine are and have been elevated.

[iseethelight]

Some people are prone to excess b6, I believe to be one of those folks. I started taking megadose b6 p5p thinking I had pyroluria but I have been the most unproductive since I started taking them. I've become a mfking potato. I've obviously stopped.

 

I wish I could help you but not sure. I heard l-glutamine might deplete b6 but I saw that on a random site, not from any scientific website/ book/ paper so take that with a big grain of sea salt. When I take glutamine, the gaba convertion makes me feel good but whatever glutamate comes out of that makes me unable to focus, and causes a minor case of chaotic mania.

Edited by iseethelight, 23 December 2015 - 12:33 AM.

[vader]

linatine lowers b6 levels

 

it is found in flaxseed