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My take on aging + an experiment

rejuvenation balance

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#31 Greg Cornes

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Posted 09 February 2016 - 01:10 AM

I have three possible ways of doing this basically, all will be supplemented with minerals and vitamins the body is unable to synthesize:

 

1) Proteinogenic Amino Acids + Glucose  

 

Theory being we still need energy to function and transcription of rna and dna

 

2) Proteinogenic Amino Acids alone

 

Theory being the amino acids coded on proteinogenic human dna actually takes into account the required energy or at least the lack of glucose causes new cells to be created from the amino acids

 

3) Proteinogenic Amino Acids + Added Glutamine

 

This allows for the possibility of the body to control it's own glucose levels when being converted from amino acids

 

All with their own variables on quantities, bio availability, conversion of excess amino acids. For example if i consume too much of serine say due to a limiting factor on the max dose you can have at one time it would be converted into excess glycine.

 

To somewhat counter this (though not entirely), i have decided the best course of action is very small doses spread throughout the day. The fibroblast cells saw great recovery within 10 days, whilst i don't expect the same results, I do believe you can somewhat reset the clock if all things taken into account are even and the time it would take would be very highly dependent on each individuals cells lifespan. 


Edited by Greg Cornes, 09 February 2016 - 01:45 AM.

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#32 Greg Cornes

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Posted 06 March 2016 - 09:55 AM

Sorry for the lack of updates.

 

However i am currently trying to find which minerals attach to which genetic tag. My laziness is proving troublesome.

 

I will explain how I am trying to achieve this.

 

DNA basics are that it is a double helix where 3' strand G binds to 5' strand C and vice versa and T has this relationship with A. 

RNA codons are identical to 3' strand of DNA with slight modifications (T is now U), three letters correlate with the amino acid which is to be bound. 

So one would assume the 5' strand would be similar however it is not created by the body, this 5' strand is the amino acids + minerals which you eat everyday, it's how the body gives itself the instructions on protein synthesis.

 

We know when protein synthesis occurs as there are starting points, AUG being one. AUG codes for methionine, so the starting point of protein synthesis is an amino acid which correlates strongly with lifespan, too much of this amino acid and your lifespan shortens. 

 

I am making a table of the number of electrons correlating to each tag, the amino acid itself does not fully complete the electron requirements which leads me to believe the remaining must correlate with the mineral, it's a work in slow progress. I may develop a program to help speed things up, as manually calculating all 64 out is tedious, whilst trying to spot patterns.

 

Interesting patterns:

 

G + C = 136 Electrons

T + A = 136 Electrons

TTG = 210 Electrons

AAA = 210 Electrons

likewise

TTT=198 electrons

AAC = 198 electrons

tables literally just started but theres patterns galore with some to be expected due to the nature of the calculation however the surprising ones is (G+C)=(T+A). 

 

There are others ill list them more properly when the table is more complete and expanded upon (shows more than just total electron number). 

 

I have been throwing some formulas at it, one nice simple one was 3 units of glycine = 60 electron deficit, which when divided by 3 left me with calcium when the codon GGG is used, another following same formula resulted in sulfur for proline which didnt make much sense but could actually just be double oxygen , i'd take this formula with a huge grain of salt however as it's got a lot of proving to do, but hopefully if i keep throwing things at it something will become evident. 

 


Edited by Greg Cornes, 06 March 2016 - 10:44 AM.


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#33 Polyamine

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Posted 06 March 2016 - 10:59 AM

One major problem with your theory is that each individual requires a different amount of amino acids per day depending on their microbiome.  You mentioned the most simple amino acid glycine in an earlier post so lets examine it briefly.  It is reasonable that someone with a protozoal infection with a high level of parasitemia may become deficient of glycine due to GCC activity.  This would also apply to someone with cancer cells that may have an arginine deficiency due to increased arginase production.  

 

http://www.jbc.org/c...283/1/155.short

 

http://www.sciencedi...952791505000142


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#34 Greg Cornes

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Posted 06 March 2016 - 11:13 AM

One major problem with your theory is that each individual requires a different amount of amino acids per day depending on their microbiome.  You mentioned the most simple amino acid glycine in an earlier post so lets examine it briefly.  It is reasonable that someone with a protozoal infection with a high level of parasitemia may become deficient of glycine due to GCC activity.  This would also apply to someone with cancer cells that may have an arginine deficiency due to increased arginase production.  

 

http://www.jbc.org/c...283/1/155.short

 

http://www.sciencedi...952791505000142

 

Certainly would be a problem. I still believe that calculating the required amount of amino acids regardless of microbiome is essential in at least knowing the minimum required of an amino acid however so I don't believe it's all in vain but i also don't believe it is 100% accurate either.

 

However things such as a protozoal infection could be corrected by fasting and following other anti aging methods, and the microbiome should adjust to your diet.

 

http://www.scientifi...e-changes-diet/

 

It does also seem you can sequence your microbiome, but the accuracy of the test looks very dubious and with the rapid shifts in microbiome, making it an incredibly unreliable tool.


Edited by Greg Cornes, 06 March 2016 - 11:40 AM.


#35 Polyamine

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Posted 06 March 2016 - 02:07 PM

 

One major problem with your theory is that each individual requires a different amount of amino acids per day depending on their microbiome.  You mentioned the most simple amino acid glycine in an earlier post so lets examine it briefly.  It is reasonable that someone with a protozoal infection with a high level of parasitemia may become deficient of glycine due to GCC activity.  This would also apply to someone with cancer cells that may have an arginine deficiency due to increased arginase production.  

 

http://www.jbc.org/c...283/1/155.short

 

http://www.sciencedi...952791505000142

 

Certainly would be a problem. I still believe that calculating the required amount of amino acids regardless of microbiome is essential in at least knowing the minimum required of an amino acid however so I don't believe it's all in vain but i also don't believe it is 100% accurate either.

 

However things such as a protozoal infection could be corrected by fasting and following other anti aging methods, and the microbiome should adjust to your diet.

 

http://www.scientifi...e-changes-diet/

 

It does also seem you can sequence your microbiome, but the accuracy of the test looks very dubious and with the rapid shifts in microbiome, making it an incredibly unreliable tool.

 

 

I completely agree with the article, but your assumption that an infection can be corrected by fasting and other anti-aging methods is something I don't agree with.  I currently have an unknown protozoal infection (possibly protomyxzoa) and have not found anything that can eradicate it.  I can knock it back, but not eliminate it.  If you know a a way to cure it, I'll certainly listen. 

 



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#36 Greg Cornes

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Posted 07 March 2016 - 12:16 AM

It would be very presumptious of me to assume I can help treat your infection, however I have read of parasitic infections being remedied from fasting anecdotally. Just out of curiosity have you tried something like a water fast in an attempt to lower their population due to starvation whilst boosting your immune system? However the general advice with fasting is to not do so unsupervised, especially considering a pre-existing ailment. The number of days required fasting would be at least 4 days mind you.

Without knowing what type of infection antibiotics are difficult, but you said you have knocked it back prior. I would assume the most direct form of action would be to take the medication which provided the best results whilst committing to a supervised fast, and carrying on the medication for a while after discontinuing the fast. Also this may be an even longer shot but it seems a lot of these parasites use the hosts hdl and ldl proteins it may be worth trying to take the prescribed medication with a omega 3;6;9 supplement or lower the ammount of fat intake to upset the new environment these parasites make for themselves, but thats just pure speculation as all of this is. I do wish you luck though in finding the answer.

Edited by Greg Cornes, 07 March 2016 - 12:57 AM.


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