There are no factors in my life that changed or affected my status during those 6 weeks other than taking 1500mg resveratrol daily. I have no sinus or respiratory conditions and the issue never involved or affected my sense of smell. I never before in my entire lifetime have had a loss of taste. My taste function entirely returned to normal in just 4 weeks after stopping resveratrol supplementation.
In the prostate cell study you reference, the authors conjecture that resveratrol forms a complex with zinc which then enters the cells. Over 4 to 6 weeks of 1500mg resveratrol daily, the intracellular take-up of that resveratrol-zinc complex is cumulative. That is, you don't need an extremely high dose of resveratrol all at once for zinc metabolism to be altered by the cumulative presence of a foreign resveratrol-zinc complex. The Carbonic Anhydrase article very clearly explains the relation between zinc and taste. There is absolutely no question resveratrol was the cause of my loss of taste.
Many forum posters probably do not use 99% pure trans-resveratrol because of cost so they are not getting the same high dose of 1500mg of pure resveratrol when they take 500mg "resveratrol" capsules. Also, the BuhnerHealingLyme author reports that only about 1% of problems mentioned by followers of his lyme disease treatment regimen involve loss of taste, so that only a relatively small percentage of resveratrol users may be susceptible to loss of taste.
45 mg of zinc is the maximum daily dose recommended by the Linus Pauling Institute to avoid copper issues, plus I also take additional copper supplements to offset the zinc dose.
When I left my auto technician job more than 10 years, I was suffering wide-spread pain in all my limbs and body. I could barely move. Now only the pain in my right leg plus the chronic fatigue still persists. There are a lot of automotive chemicals, detailing chemicals, plus exhaust in an auto shop. Large diesel vehicles, including fire trucks and utility vehicles, were serviced in that shop in a large closed, poorly ventilated enclosed building, and the diesel techs thought it was funny to fill the entire building up with smoke and diesel fumes with the doors closed. Dioxins don't disappear. They form crystals and accumulate. When many diesel trucks are being serviced daily, those dioxin crystals become a permanent, large hazardous pile of dust that permeates every crevice in the building. Only a professional environmental cleanup company can remove the toxic dust. It wasn't until 2012 before anyone even measured the amounts of dioxins, furans, and pvcs from so-called "legacy" diesel engines in an EPA study. Of all the automotive chemicals in the shop, only dioxin has a half-life long enough to cause my symptoms to persist all these years. It is a simple process of elimination. Tests for dioxin presence in the body require a very large blood draw, a specialized laboratory, and are very expensive. Plus the test values are pretty useless because everybody has some presence of dioxin and there is no safe level of dioxin. Dioxins are everywhere, including in the food we eat. There is no effective way to remove dioxins from the body. Non-absorbable oils in small daily doses, such as Olestra and mineral oil, can help eliminate some of the dioxins over a period of years. In my case, the hazard was increased because I have self-diagnosed celiac disease. 10 plus years ago my intestinal lining was leaky and my liver was already overworked keeping up with toxin removal. Dioxins only added to the problem causing a toxin overload.
One other comment: People who have never experienced the symptoms of chronic fatigue syndrome do not understand the serious debilitation and multiple symptoms sufferers experience. Minor tasks become major chores. One never awakens refreshed from sleep. Any small muscular exertion to perform a small task or go grocery shopping leaves one totally drained and sometimes bedridden for days. There is no cure. There is no diagnostic test. Sufferers look normal despite the fact they cannot function normally. There are no magic pills to alleviate symptoms. Medical professionals have been skeptical. Funding for research has been lacking despite the fact that millions of people are debilitated by the disease. I am at least partially functional, but my home is a mess and I have many chores I am simply unable to force myself to perform through pain and fatigue despite my desires to.
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