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activism metformin tame trial

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#1 Michael

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Posted 28 February 2016 - 11:52 PM


You may or may not be aware, but a couple of years ago Dr. Nir Barzilai proposed a trial to test metformin as an "anti-aging" drug in normal aging people (see press below). Late last year, FDA gave the go-ahead, with the provisional indication of "multimorbidity". Now the Global Healthspan Policy Institute, a lobbying group representing the Alliance for Aging Research and its partners, including SENS Research Foundation:




... is asking for scientific organizations and individuals to sign on to a campaign to push Congress to fund the TAME study, in THIS YEAR's appropriation cycle. I last night got an email from the American Aging Association (AGE) indicating that they need organizational endorsements and individual petition-signers to get on board by TUESDAY, MARCH 1.

Public stuff from GHPI:

Some in-depth press:



Now, it seems clear to me that metformin is a pretty unpromising candidate, except in the slightly cynical sense that mild overweight and insulin resistance is so common in the 70+ crowd that they may get some good-looking results that have little to do with even messing-with-metabolism on aging per se. But the sheer fact of having a trial funded and going that targets aging would potentially move the needle on public perception, and unless it goes disastrously wrong should help cement FDA's one-time decision to authorize such a trial into a precedent, eliminating the problem that "aging" is not currently a "disease" against which pharma can develop drugs.

So, speaking as an individual and not in my roles with SENS Research Foundation, the CR Society Board, or as an Advisor to Longecity, I would like to strongly urge everyone to sign the petition — or (better yet, since form-letter electronic petitions generally get ignored) reach out directly to your congressional reps via their official websites:



... via both their own, on-site email form and their Congressional office telephone, urging them to support and use the petition letter (click on the link in the petition that says "this personalized letter") only as model language, revising it individually to express your support on the key point: "I urge you to I urge you to support the funding of landmark medical research in the "Peer Reviewed Medical Research Program" in the Department of Defense's budget, particularly in support of the new TAME/Metformin study, to open the door to a new class of medications that protect and restore the healthy function and productivity of the human healthspan – our years of health."


Again, they need this all in their arsenal by THIS TUESDAY.

Edited by Michael, 28 February 2016 - 11:53 PM.

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#2 Antonio2014

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Posted 29 February 2016 - 01:02 AM

This is only for US citizens, it isn't?

#3 Michael

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Posted 29 February 2016 - 04:17 AM

Ah, yes: indeed, Antonio. Tho' someone could start a push for TAME-EU...

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#4 sthira

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Posted 29 February 2016 - 04:29 PM

Write your congress representatives! It's easy -- takes only a few minutes -- do it!

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#5 GHPI Matt

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Posted 29 February 2016 - 08:13 PM

Many thanks for spreading the word Michael!


The official outline and FDA confirmation can be found here: https://clinicaltria...how/NCT02432287

Everything is looking good and on track to secure the funding for the first 2 years (maximum advanced allocation) of $26 million. The voice of the public is not going unnoticed as already one of the key senators who was unconvinced has changed his mind and come on-board. Keep promoting as it's really making the difference.

I will be making updates as things progress at our facebook page: https://www.facebook...policy/?fref=ts


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