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Trehalose autophagy mechanism discovered

trehalose autophagy nash

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41 replies to this topic

#31 eighthman

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Posted 22 December 2017 - 06:59 PM

Thanks.  I think over at qualityliposomes the guy there claims that he has examined homemade liposome Vitamin C and declared that it was about as good as the lab made stuff. 



#32 Daniel Cooper

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Posted 22 December 2017 - 07:04 PM

My problem with homemade is that I just don't have the means to do quality control on my product.  I sort of have to take it on faith that I actually got my target compound (in this case trehalose) encapsulated in a meaningful quantity.  I'll do it if that's my only choice or if getting someone to make it is just too damn expensive, but it isn't my first choice.

 

 

 



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#33 eighthman

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Posted 22 December 2017 - 07:15 PM

http://qualityliposomalc.com/

 

Here we go.  I'm intrigued by this guy's research.  Claims good particle size.



#34 Daniel Cooper

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Posted 22 December 2017 - 07:21 PM

Yeah, I've read that guy's blog.  But, he apparently has some lab equipment to measure his success at creating vitamin C liposomes.  Maybe if I follow his procedure I get the same result.  But I sure would like to check that and not assume it.  And of course, trehalose is not vitamin C.  Would you get different results with trehalose?  Don't know.  Maybe someone that knows more about liposomal encapsulation could answer that.

 

 

 



#35 eighthman

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Posted 22 December 2017 - 07:32 PM

https://www.google.c...s/US20120171280

 

And the patent he refers to.  Seems to detail a method for making the stuff with good nano sizes. Woo Hoo...!



#36 Daniel Cooper

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Posted 22 December 2017 - 07:37 PM

Particle size matters in compounds that aren't lipid or water soluble, but that's not a real issue with trehalose.  All we have to do is get it across the gut wall.   

 

I guess smaller liposomes may be better at passing across the intestinal wall, so that's good.

 

 

 

 

 


Edited by Daniel Cooper, 22 December 2017 - 07:39 PM.


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#37 eighthman

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Posted 22 December 2017 - 07:40 PM

Over the holiday I can analyse the patent.  2K is a bit much for the ultrasonic thing he's using.  Devil's in the details as usual.



#38 Daniel Cooper

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Posted 22 December 2017 - 07:47 PM

I may have found a German company that will encapsulate trehalose for us as well.  I ran across them looking for liposomal resveratrol and discovered they have a broad line of liposomal products.  I would like to convince them that this is something that they would want to carry as a standard product, but failing that they mentioned they would encapsulated whatever I wanted for a 4L minimum purchase.  Don't know anything about pricing or any details.  I'll probably pick up the conversation with them after the first of the year.  I'm sort of assuming that a lot of companies in Germany will be closed between Christmas and New Year's.

 

 

 



#39 eighthman

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Posted 22 December 2017 - 07:50 PM

Hmmm...   how much $ , I wonder.  Also wonder about shelf life and shipping.  Interesting...........



#40 Daniel Cooper

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Posted 22 December 2017 - 07:54 PM

Have no details at this point. I do know that they sell variants of their liposomal products with 10% ethanol content to address the shelf life issues. 

 

This is the company that I've contacted.   https://www.actinovo...n/products/?p=1

 

Given their product line this would seem like a natural for them.  I'd really like to see someone make this as a standard product.  I think liposomal trehalose has more potential than some of the other products they already sell.

 

 

 



#41 eighthman

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Posted 22 December 2017 - 08:00 PM

Affordable. I'm impressed.

 

We gotta try this trehalose thing.  Could be the next rapamycin minus the toxicity and barriers to obtaining.



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#42 Daniel Cooper

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Posted 22 December 2017 - 08:08 PM

I know that I'm certainly taking other supplements right now that don't have the potential that trehalose has.  

 

 

 







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