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Migraine SAM-E and Triptans safe?

migraine sam-e triptans

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#1 Faustina

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  • Location:UK

Posted 04 March 2016 - 01:58 AM

Hello all,


I am new to Longecity and would like some help on treating my Chronic Migraines, currently I get around 20 days a month with migraines. I see a specialist on the NHS here in the UK and have tried multiple treatment plans which either don't work at all, have dreadful side effects or if they do work my body seems to get used to them and they just stop working after a time. Currently my neurologist wants me to try Duloxetine 60mg but I am reluctant as I have already taken an another SNRI previously to no good effect and the side effects were awful.


I am researching about migraine and alternative ways to treat it. One thing I am interested in and have purchased is SAM-E 400mg which seems a gentler way to perhaps raise serotonin and help with brain health by improving energy and lowering inflammation. I am a little worried about taking SAM-E because I still want to be able to use triptan medications sumatriptan and eletriptan when I need them during an attack. I have 12 tablets of triptan an month. Triptans and SAM-E are both serotonergic and I am a little worried about serotonin syndrome I found one article by the NHS which suggests that triptans are unlikely to cause serotonin syndrome.


Here is a quote:


"It is believed that serotonin syndrome primarily occurs through activation of 5-hydroxytryptamine 2A (5HT2A) receptors, although 5HT1A receptors may also have a role [1]. Triptans are agonists at 5HT1B/1D/1F receptors, with weak affinity for the 5HT1A subtype, and no activity at 5HT2 [1]. Consequently, triptans should not increase the risk of serotonin syndrome."


This does put my mind at rest a bit that and the fact that the doctors have been happy to proscribe an SNRI and previously Tricyclic antidepressants which I would think would have a stronger serotonergic effect than 400mg of SAM-E a day, however I am not an expert and so if anyone can offer any advice that would be great I also have some BCM 95 Curcumin and while this didn't especially help my migraines on its own I am still keen to take it because of its anti-inflammatory qualities and because I've read it can help heal brain damage. I believe that may also have serotonergic effects so perhaps the cocktail of all three is too much?


Migraine supplements I am currently using:


SAM-E 400mg

B Vitamin Complex

Extra Vitamin B2 200mg

Magnesium Malate 425mg

Co Emzyne Q10 100mg

DHA Supplement 125mg (I am vegetarian)

Basic Multivitamin


Supplements I am thinking of using but am not at present taking:


BCM95 Curcumin 400mg

NAC 600mg

MSM Powder


I am also using magnesium oil, Espom salt baths and also trying the water cure i.e. drinking 3 liters of water a day with a little extra salt to balance electrolytes and improve hydration (seems to help so far).


Are the above supplements putting me at risk of Serotonin Syndrome and would adding in the BCM 95 cause me any additional problems?


Many thanks in advance for your help!



Note: I would like to point out that I am not suffering from depression however Migraine does effect my mood causing me to cycle between euphoria and depressed mood at various times also the long term effects of chronic pain does sap my vitality and motivation to a large extent. I would like to feel more motivated and energetic not sure if SAM-E will help with that, I think reducing the number of migraine days a month I have would be a good first step!



Edited by Faustina, 04 March 2016 - 02:28 AM.

Also tagged with one or more of these keywords: migraine, sam-e, triptans

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