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review and information about cyplexinol (stem cell activator)

review stem cell cyplexinol

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#1 ironfistx

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Posted 29 May 2016 - 08:59 PM

Some of you may have heard of a product called cyplexinol which is said to generate stem cells to rebuild cartilage and bone.  There seem to be a few brands promoting this but the best price is Swanson.
Some studies say it helps with osteoporosis

Eight months after the start of the Cyplexinol® treatment, a DEXA scan showed a 10% increase in bone density which confirmed for the first time in a 53 month recorded history of bone loss in the patient not only a cessation but an actual reversal and improvement of the condition. After 34 months of treatment, a 51.5% increase in bone mineral density occurred, resulting in an osteoporotic spine becoming osteopenic.

source:  http://blog.designsf...ol-A-case-study
or osteoarthritis

Eighty-seven participants enrolled in the study.
Treatment with 150 mg of Cyplexinol resulted in a sig-
nificant decrease in pain and stiffness, together with an
increase in QOL by week 12 in comparison to placebo
treatment, which showed no significant improvement
in symptoms. The α level was set at P<.0001 for the
treatment group and P> .05 for the placebo group. For
the WOMAC pain subscale, a significant effect of a 3.35
point increase (95% CI, 2.58-4.13; P<.0001) was
observed for 150 mg of Cyplexinol at week 12 in com-
parison to a negative effect of -0.35 points (95% CI,
-1.40-0.71; P>.05) for the placebo. The mean changes at
week 12 for WOMAC stiffness were 2.95 points (95%
CI, 1.94-3.97; P<.0001) for 150 mg of Cyplexinol and
0.18 points (95% CI, -0.82-1.19; P>.05) for the placebo.
The mean changes at week 12 for WOMAC QOL were
3.12 points (95% CI, 2.38-3.86; P<.0001) for 150 mg of
Cyplexinol and -0.40 points (95% CI, -2.034-1.24;
P>. 05) for the placebo.

source: http://www.imjournal...s/garian122.pdf
Sounds wonderful right?
If you read the reviews on Swanson and Amazon, almost all of them are bad or say the product didn't do anything.  Some say it helped when they took it with glucosamine and chondroitin, something that may be suggested to do, but that could be why their joints felt better since the two supplements they were using it with are thought to help with discomfort.
A review by Regenexx suggests this product may be trying to seem like something it's not.

The “Research” page at the Cyplexinol site is a master piece of deception with regard to stem cells. Let me explain. To support that Cyplexinol is helpful for stem cells the page contains many links concerning Bone Morphogenic Protiens (BMPs). This little family of molecules are pretty cool, in that there are thousands of studies that show that BMPs can help direct stem cells to become everything from bone to cartilage. Now to do this using a stem cell culture where you can observe the effects takes incredibly specific doses of BMPs (the two most common are BMP-2 and BMP-7). Adjust that dose slightly or introduce the BMP at a different time, and you will or won’t cause stem cells to become bone or cartilage. In addition, many times to get BMPs into cells, a researcher will use a virus to carry instructions for making the protein into the cell.
What does all of this have to do with Cyplexinol? Nothing, which is where this gets very disturbing. There is nothing about a patient taking an oral supplement that might or might not contain BMPs and the research performed using very specific doses of recominanant BMPs exposed directly to cells in tissue culture. More disturbing still is that after each study where the effects of BMP’s are mentioned, the manufacturers of this dietary supplement have artificially inserted the word Cyplexinol. The message seems to be that Cyplexinol was used in the study. Here are some of the more interesting examples:

http://www.regenexx....lexinol-review/ part 1

In summary, Cyplexinol is a nutritional supplement that claims to help stem cells and plays a game that I call the BMP shuffle. What are BMPs? Bone Morphogenic Proteins, or BMPs, are found in your body and are sold commercially for research with a few used as drugs. They are very well studied proteins that can help stem cells differentiate into other cells such as cartilage and bone. The big issue is that Cyplexinol is marketed as a supplement rich in BMPs (which appears to be based on nothing more than blind faith) and as a result borrows the entire several decade body of BMP research as it’s own. In my post last year, I noted that every time that the term Bone Morphogenic Protein or BMP appeared in a random lab study which had nothing to do with the supplement Cyplexinol, the marketing team for the supplement company inserted the brand name (Cyplexinol). This is despite no evidence that I was able to find that this supplement, which is simple hydrolyzed collagen, has anything to do with BMPs.

http://www.regenexx....he-bmp-shuffle/ part 2
That is weird because Rejuv's website even talks about regenxx:
Do any longecity members use this?

Edited by ironfistx, 29 May 2016 - 09:00 PM.

#2 gamesguru

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Posted 31 May 2016 - 12:27 PM

even if its legit, wouldnt continuous use lead to a speedier depletion of stem cell stores?
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#3 ironfistx

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Posted 21 June 2016 - 04:32 PM

Can that happen?  I'm cautious about using derma rollers for the same reasons: people say your skin has a specific number of repair cycles in it and if you make them happen too early you will have problems later.

#4 gamesguru

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Posted 21 June 2016 - 06:49 PM

that's been the premise for caloric restriction, as i understand it. but then exercise would be bad? so i dont necessarily agree with everything i say. much better to trust the experts:

In most tissues, there is an age-related decline in stem cell functionality but not a depletion of stem cells. Such functional changes reflect deleterious effects of age on the genome, epigenome, and proteome, some of which arise cell autonomously and others of which are imposed by an age-related change in the local milieu or systemic environment. Notably, some of the changes, particularly epigenomic and proteomic, are potentially reversible, and both environmental and genetic interventions can result in the rejuvenation of aged stem cells. Such findings have profound implications for the stem cell–based therapy of age-related diseases.


Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes.
Aiyer HS1, Vadhanam MV, Stoyanova R, Caprio GD, Clapper ML, Gupta RC. (2008)

DNA damage is a pre-requisite for the initiation of cancer and agents that reduce this damage are useful in cancer prevention. In this study, we evaluated the ability of whole berries and berry phytochemical, ellagic acid to reduce endogenous oxidative DNA damage. Ellagic acid was selected based on >95% inhibition of 8-oxodeoxyguosine (8-oxodG) and other unidentified oxidative DNA adducts induced by 4-hydroxy-17ss-estradiol and CuCl(2) in vitro. Inhibition of the latter occurred at lower concentrations (10 microM) than that for 8-oxodG (100 microM). In the in vivo study, female CD-1 mice (n=6) were fed either a control diet or diet supplemented with ellagic acid (400 ppm) and dehydrated berries (5% w/w) with varying ellagic acid contents - blueberry (low), strawberry (medium) and red raspberry (high), for 3 weeks. Blueberry and strawberry diets showed moderate reductions in endogenous DNA adducts (25%). However, both red raspberry and ellagic acid diets showed a significant reduction of 59% (p < 0.001) and 48% (p < 0.01), respectively. Both diets also resulted in a 3-8 fold over-expression of genes involved in DNA repair such as xeroderma pigmentosum group A complementing protein (XPA), DNA excision repair protein (ERCC5) and DNA ligase III (DNL3). These results suggest that red raspberry and ellagic acid reduce endogenous oxidative DNA damage by mechanisms which may involve increase in DNA repair.

Effects of Epimedium flavonoids on proliferation and differentiation of neural stem cells in vitro.
Yao R1, Zhang L, Li X, Li L. (2010)

The purpose of this study is to investigate the effects of Epimedium flavonoids (EF), which is extracted from a traditional Chinese Epimedium herb, and its effect on the proliferation and differentiation of neural stem cells (NSCs) in vitro.
The single cells isolated from the hippocampi of 1 day old neonatal rats were cultured in a serum-free condition medium DMEM/F12 (1 : 1) with different concentrations of EF or 20 ng/ml epidermal growth factor (EGF) and 10 ng/ml basic fibroblast growth factor (bFGF). After 7 and 28 days, the neurospheres' diameters were measured. The formed neurospheres were cultured in the differentiation medium containing EF or 10% fetal bovine serum (FBS). After 12 hours and 7 days, immunofluorescent studies for nestin, Musashi-1, BrdU, beta-III-tubulin, NF-200 and GFAP were performed. The number and lengths of 10-15 axons of NF-200 immunopositive cells were measured.
The results showed that the isolated cells had the ability to propagate as neurospheres in the medium with 200 and 400 m g/ml EF, but without any EGF or bFGF, and the volume of neurospheres increase gradually from 7 to 28 days. In comparison with FBS control, the number of NF-200 positive neurons had significantly increased in the EF groups where the newborn neurons were morphologically more mature and able to migrate farther away from neurospheres than in the FBS control.
The results demonstrate that EF effectively promotes the proliferation and differentiation of NSCs in vitro, suggesting that EF may have new properties of regulating central nervous system function by neurogenesis.

A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-β Modulating Mitochondrial Energy Metabolism
Yu-qin Mei, Zong-fu Pan (2016)

Relatively little is known regarding mitochondrial metabolism in neuronal differentiation of embryonic stem (ES) cells. By using a small molecule, present research has investigated the pattern of cellular energy metabolism in neural progenitor cells derived from mouse ES cells. Flavonoid compound 4a faithfully facilitated ES cells to differentiate into neurons morphologically and functionally. The expression and localization of peroxisome proliferator-activated receptors (PPARs) were examined in neural progenitor cells. PPAR-β expression showed robust upregulation compared to solvent control. Treatment with PPAR-β agonist L165041 alone or together with compound 4a significantly promoted neuronal differentiation, while antagonist GSK0660 blocked the neurogenesis-promoting effect of compound 4a. Consistently, knockdown of PPAR-β in ES cells abolished compound 4a-induced neuronal differentiation. Interestingly, we found that mitochondrial fusion protein Mfn2 was also abolished by sh-PPAR-β, resulting in abnormal mitochondrial Ca2+ ([Ca2+]M) transients as well as impaired mitochondrial bioenergetics. In conclusion, we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2+, PPAR-β took an important role in neuronal differentiation induced by flavonoid compound 4a.

Role of flavonoids in future anticancer therapy by eliminating the cancer stem cells.
Sak K1, Everaus H. (2015)

Despite the numerous recent advances made in conventional anticancer therapies, metastasis and recurrence still remain the major problems in cancer management. The current treatment modalities kill the bulk of the tumor, leaving cancer stem cells behind and therefore, the agents specifically targeting this cancer initiating cell population may have important clinical implications. In this review article, the data about the inhibitory action of flavonoids, both natural as well as their synthetic derivatives, on the self-renewal capacity and survival of cancer stem cells of different origins are compiled and analyzed. These data indicate that several plant secondary metabolites, including soy isoflavone genistein, green tea catechins and a widely distributed flavonol quercetin, have the potential to suppress the stemness markers and properties, traits of the epithelial-to-mesenchymal transition and migratory characteristics, being also able to sensitize these cells to the standard chemotherapeutic drugs. These polyphenolic compounds act through multiple signal transduction pathways, providing thus the maximal therapeutic response and offering some promise to be included in the future cancer treatment schemes in combination with the conventional therapies. Such approach may give an important contribution to the shift of cancer management from palliative to curative mode, likely leading to the disease-free survival. Thus, flavonoids can serve as attractive candidates for novel anticancer agents by eliminating the roots of cancer.


another study found p38α/β inhibition to promote stem cell rejuvenation (against induced deficits)

#5 normalizing

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Posted 22 June 2016 - 04:22 AM

wtf is a flavonoid compound 4a lol what a ridiculous name and where does it come from anyway

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#6 gamesguru

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Posted 22 June 2016 - 03:03 PM

if you SciHub the full article, maybe it tells the plant source? although such generosity is not to be expected, with all those Asian authors. so it's just compound 4a bruhhhhh, no questions! all i can say is, according to the generous researchers, it looks something like this

Attached File  4a.jpg   3.76KB   0 downloads

#7 ironfistx

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Posted 22 June 2016 - 07:07 PM

It's on clearance now at Swanson for anyone who is interested.

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#8 normalizing

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Posted 23 June 2016 - 05:45 AM

seems like shit sorry and i still cant figure out what flavonoid compound 4a is, thats how those asians work its true, they use their own way of describing things completely confusing to the western made studies. their crappy names for things, ending up with missing out on a lot of beneficial elements out there


btw why would people buy supplements for stem cell renewal anyway in this current age of advancement in technology, you can basically have stem cell operations soon with high probability they are 100% efficient versus taking capsules lol thats like going back to to primitive age using sticks to make fire all meanwhile having the freedom to use your modern cookware. But, with the deficient in all terms argument of "BUT ITS NATURAL DUDE" some might fall for it, sadly :(

Edited by normalizing, 23 June 2016 - 05:51 AM.

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