42 replies to this topic

[Crepulance]

I know, I know it's a repeated post, but the others are so old, no one pays them any head, so please allow for this post to stay up, if only for a short while to gain some traction... Okay, very curious to know if anyone out there has any new or inside information on Myostatin Blockers. There are a few in development, but that's about all that I know. For those who don't know, Myostatin Blockers, prohibit the body from prohibiting muscle growth, resulting in incredible increase in lean muscle, and reduction of body fat. Like those giant cows and dogs you see pictures of online now and then. Anyway, you're all geniuses here, so I figured I'd toss the hat in the ring and see if I can get any responses. For those who give me a solid lead first, I'll allow them the first match of superstrength armwrestling with me!


Crep

[Matthias]

I know, I know it's a repeated post [thread], but the others are so old, no one pays them any head, so please allow for this post [thread] to stay up, if only for a short while to gain some traction...

Old threads automatically pop up to the top again in the subforums and they also appear in the active topics list, when somebody adds new posts to them.

(edited by Matthias: 3 threads merged: showtopic=24161 & 23629 & 18231)

Edited by Matthias, 06 September 2008 - 11:23 AM.

[caston]

The article appears dead now. Do you have another link?

Do we know what genes are responsible for myostatin production? In some people and animals the genes are damaged or switched off so it would be interesting if we could find out which gene these was.

[simon007]

Hi Caston,

You can check this link http://www.ergogenics.org/archmyo.html. There's a lot of info about myostatin blockers.
The descriptions of the articles are in dutch, but if you open the article's you'll see that most of them are in English.

There are rumours that people have been experimenting with myostatin blockers in the body building scene and that's the reason some of these guys are so big.

Cheers,

Simon

Edited by simon007, 23 January 2009 - 10:29 AM.

[caston]

Hi Caston,

You can check this link http://www.ergogenics.org/archmyo.html. There's a lot of info about myostatin blockers.
The descriptions of the articles are in dutch, but if you open the article's you'll see that most of them are in English.

There are rumours that people have been experimenting with myostatin blockers in the body building scene and that's the reason some of these guys are so big.

Cheers,

Simon

Cheers Simon. I found this article particularly interesting: http://www.ergo-log....tintendons.html

It appears as though removing the genes in mice that produce myostatin results in stiffer and weaker tendons.

You probably don't want to get rid of myostatin altogether just get a little less of it.

Edited by caston, 23 January 2009 - 12:33 PM.

[Zenob]

Hi Caston,

You can check this link http://www.ergogenics.org/archmyo.html. There's a lot of info about myostatin blockers.
The descriptions of the articles are in dutch, but if you open the article's you'll see that most of them are in English.

There are rumours that people have been experimenting with myostatin blockers in the body building scene and that's the reason some of these guys are so big.

Cheers,

Simon

Cheers Simon. I found this article particularly interesting: http://www.ergo-log....tintendons.html

It appears as though removing the genes in mice that produce myostatin results in stiffer and weaker tendons.

You probably don't want to get rid of myostatin altogether just get a little less of it.

I've tried myostatin blockers before while I was weight lifting. Zero results. I think the bio-availability of the various blockers on the market are just way too low to have any kind of actual effect. Be nice if they did though. Take a look at the bull in this article. It's a mutant and has very low levels of myostatin. That thing could run through a brick wall. They should turn these things loose in Spain. Those bull fighters wouldn't know what hit them...

Link

[simon007]

Check out Wendy http://blogmuscle.fi...7/07/wendy1.png, if this dog catches a burglar you don't find his sneekers :-)

This dog has genetic defect which caused the gene for myostatin to stop functioning.

Myself I'm not into body building so I don't have any personal experience. I'm happy the way I am, see picture http://www.geenstijl...s/murmelaar.jpg

Edited by simon007, 24 January 2009 - 08:01 AM.

[Zenob]

Check out Wendy http://blogmuscle.fi...7/07/wendy1.png, if this dog catches a burglar you don't find his sneekers :-)

This dog has genetic defect which caused the gene for myostatin to stop functioning.

Myself I'm not into body building so I don't have any personal experience. I'm happy the way I am, see picture http://www.geenstijl...s/murmelaar.jpg

I've seen that dog too. The picture doesn't do it justice. Wendy is a whippet. Those dogs tend to be very thin and "aerodynamic" which makes Wendy just that much more of a monster. Here's a picture of a normal whippet and that picture of Wendy just so you can see what I'm talking about.

Attached Files

•  whippet.jpg   213.32KB   1 downloads
•  wendy1.png   454.37KB   1 downloads

Edited by Zenob, 25 January 2009 - 04:18 AM.

[Skötkonung]

Interesting. I read that folstaxan, a protein found in fertilized chicken eggs, elevates follistatin and that in turn negatively influences myostatin. It was featured in MD magazine.

Anyone hear about this?

[demsd]

Yeah, I agree that there has to be a serious downside, if their claims are even true. They do mention that it only blocks it for skeletal muscle not heart, but I am not finding any of their claims convincing. One of the reasons I was curious is because I am interested in sea minerals/vegetables as a supplement. My Dad has used them very effectively in lowering his PSA. I was wondering what else they might specifically be good for.

Myostatin has no effect on the heart. When it occurs naturally, and its not something that happens often in humans, it will only effect the growth of skeletal muscle. For example, there is a boy in Michigan, Liam Hoekstra, who is 3 years old. He is affected by the "condition." Based on strength tests, he is 2 to 2.5 x's stronger than other 3 year olds. There is also a boy in Germany who is Myostatin deficient. At 5 [now 8 or 9 years] he was able to hold seven-pound weights with his arms extended.

Read bout Liam here:

http://www.mlive.com...all_muscle.html

read about the "Germany baby Superman" here:

http://www.chinadail...tent_342496.htm

Info at The New England Journal of Medicine:

http://content.nejm....ort/350/26/2682

[Boondock]

This is potentially an amazing discovery. If the side-effects on tendons aren't too severe, myostatin inhibitors would be strongly preferable over the sexual sides of steroids, and a lot more effective. For a 'hardgainer' like me, it might be that the body is producing higher-than-normal levels of myostatin in the first place, and blocking some wouldn't be such a bad idea.

Has anyone got any more information about the development of this? Most of the purported online blockers seem to be fake, and I can't find any drugs close to trial completion for this.

[curious_sle]

Well, still no news huh? :-(

[Mind]

Another gene pathway and corepressor that blocks muscle development. Perhaps another target for the treatment of sarcopenia (and for body builders to get huge)


Tweaking a gene makes muscles twice as strong

A team of researchers at EPFL, the University of Lausanne and the Salk Institute created super strong, marathon mice and nematodes by reducing the function of a natural inhibitor, suggesting treatments for age-related or genetically caused muscle degeneration are within reach.
It turns out that a tiny inhibitor may be responsible for how strong and powerful our muscles can be. This is the surprising conclusion reached by scientists in EPFL's Laboratory of Integrative Systems Physiology (LISP), in collaboration with a group in the Center for Integrative Genomics at the University of Lausanne and at the Salk Institute in California. By acting on a receptor (NCoR1), they were able to modulate the transcription of certain genes, creating a strain of mighty mice whose muscles were twice a strong as those of normal mice.
Two protein-building regulators
The process of transcription, in which proteins are manufactured by an organism in response to instructions contained in its DNA, is modulated by co-factors. These either favor (coactivators) or inhibit (corepressors) transcription, in principle by responding to the concentration of certain hormones in the body, which are in turn associated with the organism's environment.
In an article appearing today in the journal Cell, a team led by EPFL professor Johan Auwerx reports on the results of experiments done in parallel on mice and nematodes. By genetically manipulating the offspring of these species, the researchers were able to suppress the NCoR1 corepressor, which normally acts to inhibit the buildup of muscle tissues.
Better muscles
In the absence of the inhibitor, the muscle tissue developed much more effectively. The mice with the mutation became true marathoners, capable of running faster and longer before showing any signs of fatigue. In fact, they were able to cover almost twice the distance run by mice that hadn't received the treatment. They also exhibited better cold tolerance.
Unlike previous experiments with so-called super mice, this study addresses the way energy is burned in the muscle and the way the muscle is built. Examination under a microscope confirmed that the muscle fibers of the modified mice are denser, the muscles are more massive, and the cells in the tissue contain higher numbers of mitochondria--cellular organelles that deliver energy to the muscles.
Similar results were also observed in nematode worms, allowing the scientists to conclude that their results could be applicable to a large range of living creatures.