Hi
I found this site while using Google to keep up to date on the latest GDF11 and blood plasma ageing research, just curious to see if anyone within these forums is interested in reversing the ageing process ?
What I have discovered so far is that GDF11 does after some conflicting results due to reagent issues appear to be one of (if not the most) important proteins responsible for re-activating the human body to repair itself at a faster rate and hence return one to a more youthful state.
However one thing I am concerned about is, that this is still not absolutely certain and I think there must be a lot more proteins and hormones, etc within young blood that causes one to revert to youthful state, also some proteins/hormones that are increased with age that may need cancelling out in addition to just GDF11 supplements; also and most importantly the latest research suggest the therapeutic dose of GDF11 required to rejuvenate oneself is 0.5mg/Kg which at current prices would be roughly £160,000 per week for 4 weeks of treatment based on frequency of injections and experiment time frame used in the mouse studies.
So attempting to use GDF11 injections in my opinion would be very expensive and most probably not capture all the youthful factors required to healthily revert one to a youthful state, and that is if GDF11 is 100% verified as the master protein responsible for dictating ones age based on it's blood level.
This leaves another alternative which is to obtain Blood Plasma from two volunteers twice per week, at a therapeutic dosage in line with regular plasma treatments which are carried out in Hospitals around the world all the time, so for someone weighing 80Kg this would equate to 1200ml of Plasma twice a week for 4 weeks duration, which in mouse studies was time enough to revert ones age. So each donor would donate 600ml of plasma twice a week and no closer than 48hrs between donations in line with best practices.
This would ensure whatever is in the young blood plasma is received by the recipient, so as yet unidentified factors would be included; this should be very safe as long as best practices are followed in that the worst case scenario is that it simply does not work... but all available information indicates results would be quick to materialize.
Within the UK as far as I have been able to identify there is nothing illegal about investigating this approach, although it does raise eyebrows when discussed with people who are not educated within the medical profession or have amateur scientific tendencies.
I have educated myself on Haematology processes, Blood/Plasma donation processes, Blood typing and cross matching etc... in fact read everything and anything I can on the internet to assimilate the required information to enable me to proceed with DIY Plasma donation trial to reverse ones age... for example I have a 3 channel Baxter IV pump, all IV supplies, blood matching/typing identification cards, health monitoring equipment, all sterile supplies necessary for safety, and most importantly Plasmapheresis filters rather than centrifugal plasma separation apparatus as it's technically superior and safer.
Technically I'm ready to proceed but have no Plasma donor volunteers, and to be honest I haven't really tried to find any at this stage as I have other projects on the go so am often juggling time between them... I do talk to friends and colleagues about what I am doing but they are all roughly my age, which is 41, so are very interested but not suitable as donors; then I found this site and thought I may as well introduce myself and see what other people are doing and see if there is interest
I have opted when the time comes to go the DIY route instead of just buying Blood Plasma which is readily available from suppliers from roughly £97 per 500ml, with suppliers able to provide from age, gender, and either same donor or pooled as required.... this is purely for safety reasons in that it would ensure the risk of contracting viruses would be greatly reduced and confidence of sourcing Plasma from compatible males below or as close to 21yrs old as possible would be ensured.
Male donors only would rule out risk of TRALI reactions as although rare it only happens with female donor Plasma, most importantly there is a lot of examples documented on the Internet going back decades of Plasma sourced from reputable companies actually being contaminated... hence having two named donors on board the experiment would reduce risks greatly compared to sourcing Plasma commercially.
I also think it would be best for donors to register and perform one Plasma donation at a reputable clinic before proceeding as volunteers for such an experiment as this would ensure donor criteria are met and all required tests are completed by the clinic which would ensure safety of the donor and plasma for recipient.
I'd be very interested to receive feedback on the above to ascertain peoples opinions on if it's a viable experiment ?
Kind Regards,
James....