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[JackieJackJackenstein]

I'm pretty happy with the meds that I'm taking right now, but there's one side effect of quetiapine that I would want to be rid of. I'm absolutely sure that it is the cause because I went off of it for a few days and the side effect subsided. It's a sexual side effect that counteracts my SSRI's... "porn starification" effect. I'm taking 75mg/day XR right now.

 

Anyway, several articles mention that quetiapine "rapidly dissociates from D2 receptors". What does this mean? Does it stop acting on D2 over time? How long do you guys think it would take? Will the other dopamine receptor types such as the D1, D3 and D4 also be affected? It's having a pretty strong effect on me even at 75mg.

 

It isn't really something worth quitting it for, but I would like to know if it will stop having this side effect on me.

 

Source: https://www.ncbi.nlm...les/PMC1408069/

 

http://psychopharmac..._run_hypothesis

 

"Since atypical drugs show a lower affinity and a faster dissociation, a higher koff for the D2 receptor is proposed as a mechanism for "atypical" antipsychotic effect."

Edited by JackieJackJackenstein, 20 July 2016 - 03:05 PM.

[psychejunkie]

 

 

several articles mention that quetiapine "rapidly dissociates from D2 receptors"

 

This is an effect also called as "kiss and run effect", which means molecule rapidly binds on receptor and detach from it.

many medications (ex. atypical antipsychotics, etc) have this same effect on different receptors and there are hypothesis that kiss and run effect also contribute to drugs MoA or side-effects.

Edited by psychejunkie, 25 July 2016 - 11:18 AM.