14 replies to this topic

[TheFountain]

So

 

I heard through the wire that Pomegranate extract is good for blocking estrogen, so I have been trying it for about 4 weeks now. 

 

At first I could see the results of its estrogen blocking effects.

 

But the past two weeks I started feeling increasingly tired, waking up feeling more and more low in energy.

 

It turns out Pomegranate concentrate also messes with Androgen receptors as well! 

 

Now, when it comes to the following study, it appears to be a good thing.

 

But with regard to virility perhaps not so much.

 

Tell me what you think.

 

" The results showed that POM (0-12μg/mL) reduced the production of testosterone, DHT, DHEA, androstenedione, androsterone, and pregnenolone in both cell lines."

 

Holy shit. So, am I shit out of luck with regard to blocking estrogen while trying to increase free test? 

 

http://www.ncbi.nlm....pubmed/24565566

[William Sterog]

What about Rhodiola?

12.1. Estrogen

A standardized extract of rhodiola (3% rosavins and 1% salidroside) is able to competitively inhibit estrogen binding to the receptor in a concentration dependent manner[125] and when given to ovarectomized rats fails to show estrogenic effects (and instead caused a nonsignificant anti-estrogenic trend in some rats due to increasing the metabolism of estradiol).[125]

https://examine.com/...rhodiola-rosea/

But I cannot find any serious source about its effects on testosterone.

[platypus]

Why do you think you have problems with estrogen? Do you have excessive belly-fat for example? 

[Castiel]

Rhodiola has also been shown to enhance calorie restriction lifespan extension, by doing lifespan extension in an independent manner, resulting in additive lifespan extension when combined with calorie restriction, at least in some insects.

[sativa]

...
Holy shit. So, am I shit out of luck with regard to blocking estrogen while trying to increase free test?

No you're not!

You should read this thread on testosterone boosters. It literally mentions most valid testosterone boosting methods.

Http://www.longecity.org/forum/topic/86380-natural-testosterone-boosters

Edited by sativa, 02 September 2016 - 07:02 PM.

[TheFountain]

Why do you think you have problems with estrogen? Do you have excessive belly-fat for example? 

No,

 

But I am taking testosterone supplements and my concern is they will inadvertently raise estrogen as well.

 

I had the same effect with DIM. 

[TheFountain]

What about Rhodiola?

12.1. Estrogen

A standardized extract of rhodiola (3% rosavins and 1% salidroside) is able to competitively inhibit estrogen binding to the receptor in a concentration dependent manner[125] and when given to ovarectomized rats fails to show estrogenic effects (and instead caused a nonsignificant anti-estrogenic trend in some rats due to increasing the metabolism of estradiol).[125]

https://examine.com/...rhodiola-rosea/

But I cannot find any serious source about its effects on testosterone.

So you're saying Rhodiola may block estrogen but it also may cause problems with androgen reception? 

[Junk Master]

Boron.  I use Swanson's Triple Boron complex 3 on a two weeks on, two weeks off cycle.  No affiliation with Swanson's...

[TheFountain]

Boron.  I use Swanson's Triple Boron complex 3 on a two weeks on, two weeks off cycle.  No affiliation with Swanson's...

But will it fuck with androgen receptors as well? Will it also lower testosterone like these other shit supplements? 

[TheFountain]

Boron.  I use Swanson's Triple Boron complex 3 on a two weeks on, two weeks off cycle.  No affiliation with Swanson's...

Yea but does it fuck with aromatase as well and lower testosterone?

[Nate-2004]

Interesting. I've been taking pomegranate extract for the last couple weeks now because when the gordonibacter species of the microbiome consume it, it's metabolized into 'Urolithin A' which restarts mitophagy, at least in labs.

 

I hadn't heard anything about it blocking estrogen, much less androgen receptors.

 

I'll go easy on that then.

 

Apigenin is an aromatase inhibitor as well, it also inhibits CD38 but there's some discussion in the NR thread as to whether it inhibits sirtuins. Nothing to suggest it does other than hypothesis though.

 

 

Edited by Nate-2004, 17 September 2016 - 02:27 PM.

[TheFountain]

Interesting. I've been taking pomegranate extract for the last couple weeks now because when the gordonibacter species of the microbiome consume it, it's metabolized into 'Urolithin A' which restarts mitophagy, at least in labs.

 

I hadn't heard anything about it blocking estrogen, much less androgen receptors.

 

I'll go easy on that then.

 

Apigenin is an aromatase inhibitor as well, it also inhibits CD38 but there's some discussion in the NR thread as to whether it inhibits sirtuins. Nothing to suggest it does other than hypothesis though.

DIM is another supplement that totally fucked with my energy in a bad way.

 

I tried it for about two weeks and my energy was completely gone and my male-ness was on hold. I felt too lacking in energy to be a complete man and it made me almost asexual.

[elc202]

I don't understand the study, but isn't it about prostate cancer patients? why do you think it applies to healthy men?

Also what is the exact dosage, it only says (0.17 g/L in drinking water) but how much water are they drinking? I take 300mg POMELLA (30% punicalagins) extract per day, and now I'm now sure if I should stop....

[Rocket]

Not all estrogen blockers are the same. Consider arimidex and tamoxifen. Need to be careful about what is meant by blocking estrogen and in what tissues it is blocked.

[Rocket]

Not all estrogen blockers are the same. Consider arimidex and tamoxifen. Need to be careful about what is meant by blocking estrogen and in what tissues it is blocked.

 

Also, if you are going to play with your estrogen values, then you need a blood test to know what your estrogen numbers are. Are they high? Then it is a good to bring them down into range to lower your risk (especially men) of heart issues, strokes, and fat accumulation. If they are low, then you are again risking the same health issues + osteoporosis. If you take an estrogen inhibitor that isn't systematic and not acting all all estrogen in all tissues, then you can end up raising your estrogen numbers.

 

People need to be careful about opening up the Pandora's box of experimenting with hormones because everything is interconnected. You just don't lower E or raise T without causing waterfall issues downstream. That's why bodybuilders get blood tests and take multiple multiple other substances to mitigate the downstream effects.

 

 

Edited by Rocket, 18 September 2019 - 12:38 PM.