ON another note...! My mind is returning to strength - the NMDA-antagonism of MagLT actually seems to be helping - a liittle bit - seems like the effects are NOT as dramatic as I foresaw - you need quite the hefty dose...
BUT... you should NOT give up on NMDA-antagonism! The researchers shouldn't either. The NMDA-network is involved with nearly every other region in the brain - they control a great deal of inter-network communication - that's why antagonising them can reverse tolerance to so MANY drugs!
Now then... my mind is working here... could the NMDA-network be involved in neural sensitivity? Autism is well-known to also include not just Social difficulties, but to almost always include alterations to sensoric perception - light-sensitivity, sound-sensitivity - these are common problems.
In fact, for a few, they even have LESS social difficulties, and MORE Sensoric! : O Being able to tell decently whether someone is happy or not, but not being able to leave the house without Prescription sun-glasses! Having to live in perpetual twilight - this is reality for some Autists - and not enough effort is being put into understanding THAT aspect of the disease!
I have an idea though... could Autism be related to NMDA-network mitigated neuronic firing-rate? This recent data has actually found how glutamatergic neurons are controlled, and how the process regarding neuro-cellular sensitivity works...
Neuroscientists Identify a Protein That Allows Brain Cells to Dampen Their Sensitivity
http://scitechdaily....ir-sensitivity/
NITRO-memantine bay-bee...
Remember those baby Rats with autism? High-dose Nitromemantine seemed to affect their symptoms... could HIGH-yield, yet also selective, NMDA-antagonism be the answer? I know our good friend Farware has become convinced glutamateric modulation is the key as well, but I think he may have missed this part... Glutamate ultra-receptor-activity... could it be a key feature of autism symptopathology? The sensoric issues leads me to believe this... because this study just proved that there's a perticular process which can be affected, to change sensitivity to currented information within neurons.
I have seen studies where Nitromemantine seems to enhance synaptic growth, and I know that similar studies was recently proven with MagLT (magnesium is ALSO a non-competitive NMDA-antagonist). And isn't Synaptic super-growth one of the previously suspected pathologies of Autism? Synaptic density would have an impact on neural and sensoric sensitivity, methinks...
Sounds exactly like the problem to me, but what do I know! I'm just a mad-man with a highly curious way of thinking, living somewhere at the very edge of the world.
(jesus christ it's cold here...! For some reason I feel as if MagLT enhances sensoric input for me - hearing and feeling is dialed up to 11! Not emotion though, curiously - it enhances emotonal control. Could of course be NSI-189 too.)
EDIT:
Some interesting info here - Doreengreen mentions a few things that we need to have a look at. Autism is the most advanced of all neuropsychiatric diseases, dwarfing even the feared and dreaded schizophrenia - some complex stuff this. Glutamatergic interaction and activity seems to fit almost everything she says though, to some extent... hmm...
https://www.reddit.c...of_autism_some/
On another note - what are your thoughts, if any, on the whole neurodiversity claim, and it's proponents? That research is apparently not as important as education and societal evolution.
Personally I find it to be RUBBISH! Yeah, the evolutionary reasoning for all of these diseases makes sense - they're poly-genetic, and involve many traits, but the Stoneage was 40,000 years ago - things have changed! And evolution keeps on trucking - evolutionary failures as well - once you have too many symptoms, the cons start out-weighing the pro's IMNSHO.
Speaking for myself regarding my own neural curiosities - If there were clear genetic targets for Concentration Deficit Disorder I wouldn't hesistate a SECOND! I'd BREAK into the research labs - I'd STEAL every note on the targets, I'd detonate the locks to the nano-tech research labs, I'd deploy automatic sentries around the whole facility to keep any irritants out of my way, and I'd prepare NEW, highly experimental nano-robots with a new, curious neuro-electric control-mechanism, and inject them MYSELF!
Give me post-humanity or give me DEATH!
Edited by Stinkorninjor, 01 October 2016 - 06:19 PM.