3 replies to this topic

[PeaceAndProsperity]

There are amino acid competition between tryptophan and phenylalanine,  tyrosine but what about glutamine/glutamate and other amino acids or chemicals? I have tried searching repeatedly but as usual to no avail. 

Obviously the goal is to deplete glutamine/glutamate contents in the brain.

[gamesguru]

asparagine[1] and creatine.

 

much weaker, and specific to only one of three Glu uptake sites, are citrulline, carnosine, and histidine[2]

[PeaceAndProsperity]

asparagine[1] and creatine.

Asparagine.. hmm. Might this prove useful in autism where there are too large concentrations of glutamate and problems with degrading glutamate? Maybe I should give it a try.

I wonder, does its Wikipedia page suggest that it can both be forrmed from glutamate but also become it?

 

 

Asparagine usually enters the citric acid cycle in humans as oxaloacetate.^{[citation needed]} In bacteria, the degradation of asparagine leads to the production of oxaloacetate which is the molecule which combines with citrate in the citric acid cycle (Krebs cycle). Asparagine is hydrolyzed to aspartate by asparaginase. Aspartate then undergoes transamination to form glutamate and oxaloacetate from alpha-ketoglutarate.

[gamesguru]

Five pathways and three steps in the ladder later, and we have a weak connection.  But seriously, this association is so indirect that I honestly think you are reading too much into it.  It's easy to get caught on these tangents.  But something as simple as making a move to a plant protein with low glutamic acid (have to check every profile, cause some plant proteins actually have more gluamate than whey!!)

 

Curcumin inhibits glutamate release, green tea promotes uptake (and more weakly, it also induces a release), and Radix subspecies inhibit the glutamate synthesizing enzyme GLDH.  Cannabis also appears to lower glutamate levels, but not without a trade-off. From tomatoes, tomatine and tomatidine, may also be useful.  They lessen Glu toxicity and are α7 agonists (this was new infromation to me)