LONGECITY

Ok dudes and dudettes. So far I can consistently link this to meat consumption or any high protein consumption... Must be an amino acid imbalance occurring. I can also reproduce this symptoms by taking any of the following: tyrosine, l dopa, tryptophan, 5htp..

 

Edited by iseethelight, 10 January 2017 - 11:06 PM.

high serotonin plays a role in such a wide spectrum of pathologies as social phobia, ocd, seasonal depression, and anorexia.  Natural inhibitors of the tryptophan hydroxylase enzyme include eleuthero, arginine nitrate, and bai shao yao.  

 

That would be the preferred method of lowering serotonin turnover, forgoing of course the ability to monitor dietary amino acid intake.

 

For tyrosine hydroxylase, Corydalis, 2-Hydroxyestradiol, and Oudenone (apparently found in fungus?)

 

It may simply even be a problem of norepinephrine, that's dopamine's metabolite

Ok dudes and dudettes. So far I can consistently link this to meat consumption or any high protein consumption... Must be an amino acid imbalance occurring. I can also reproduce this symptoms by taking any of the following: tyrosine, l dopa, tryptophan, 5htp..

 

funny that you mentioned this. i continue my own "study" on different types of breakfasts vs blood glucose vs tired. now, because people rated my previous glucose numbers as "dangerous and irresponsible," i'm not going to post them, but suffices to say high protein/egg based breakfasts did make me tired, but in a different way than high carb ones. more wired and anxious rather than plain sleepy.

How about vegan protein, a plate of seasoned sauteed veggies and a light cup of tea?  It always sits really well with me.  A lot better to start your morning with that than whey isolate (which I prefer to save that for later in the day when I already have lots of nutrients in my blood and just need a lil protein boost).

 

I also find that eating a lot of meat (or carbs) first thing in the morning can backfire.  Another point to consider... vegan protein has phytochemicals and things that whey doesn't, and it (sometimes) tends to be lower in glutamic acid, tryptophan and tyrosine (the offending aminos)

This happens to me....

 

i can be feeling OK and then ill eat a meal - acute depression comes over me and i feel like crying 

 

wtf is happening :(

check your serum ammonia after you eat meat

 

How can I do that? I couldn't find any human test kit for sale online. This might be my issue, ammonia...

 

check your serum ammonia after you eat meat

 

How can I do that? I couldn't find any human test kit for sale online. This might be my issue, ammonia...

 

Are you in the US?

 

 

check your serum ammonia after you eat meat

 

How can I do that? I couldn't find any human test kit for sale online. This might be my issue, ammonia...

 

Are you in the US?

 

Yep

quest and labcorp will both look

Ok, new findings. I think our issue is high glutamate . An inability to get rid of excess glutamate, which results in excitotoxicity, low gaba, high acetylcholine.. which results in major depression. This can be a big breakthrough. I'm going to try following a low glutamate diet and report back in a few weeks before expanding further on this...

Edited by iseethelight, 21 July 2017 - 04:20 AM.

Personally, I had this until I switched to a ketogenic diet with lots of vegetables and ~70% fat. Even eating carbohydrates like yams seems to make eating result in mental health issues and fatigue. And I used to be completely fine consuming lots of carbohydrates. YMMV though, I have some combination of ASD/ADHD/Migraines, all of which seem to involve glutamate excitotoxicity.

Ok, new findings. I think our issue is high glutamate . An inability to get rid of excess glutamate, which results in excitotoxicity, low gaba, high acetylcholine.. which results in major depression. This can be a big breakthrough. I'm going to try following a low glutamate diet and report back in a few weeks before expanding further on this...

I joined this forum to hopefully see how your low glutamate diet is going? Ive also noticed being low energy and deppressed immediately after eating. I eat a pure paleo diet and it definitely helps me be more clear headed but I still struggle being happy. Ive noticed this especially after meals and was wondering if anyone has figured out what is going on with us? Is it all just leaky gut? Or something else.

low glutamate diet.  new findings.  what have you been living under a rock son?

 

likely explanations are either reactive hypoglycemia or tryptophan intolerance.  if the body is unable rid itself of excess serotonin, undesirable conformational changes and downregulation processes take place.  as for the hypoglycemia, it can be largely subclinical, rousing only such symptoms as dizziness upon sudden standing which would commonly be dismissed as common and benign, or in the case of mild cognitive impairment, being too subtle and self-belittling for the average subject to garner with his or her naked eye

 

you can get a very pronounced anti-glutamate effect from curcumin and magnesium.  they'll regulate your body both ways, whether deficient or excessive.  that's the beauty of reversible inhibitors when compared against stuff like riluzole and memantine, which have clear tolerance and safety concerns.  speaking of mag and curcumin, i haven't really done any of my own cooking this week and that's probably why it's been so unproductive..

 

A possible role of CUR to attenuate both glutamate level and gene expression of NMDA2B and mGLUR5 in brain hippocampus was established when compared to MSG group.

 

and...

The findings suggest that therapeutic NMDA receptor block in neonates requires higher concentrations of magnesium sulphate in brain tissue.

 

Ok, new findings. I think our issue is high glutamate . An inability to get rid of excess glutamate, which results in excitotoxicity, low gaba, high acetylcholine.. which results in major depression. This can be a big breakthrough. I'm going to try following a low glutamate diet and report back in a few weeks before expanding further on this...

I joined this forum to hopefully see how your low glutamate diet is going? Ive also noticed being low energy and deppressed immediately after eating. I eat a pure paleo diet and it definitely helps me be more clear headed but I still struggle being happy. Ive noticed this especially after meals and was wondering if anyone has figured out what is going on with us? Is it all just leaky gut? Or something else.

 

While I'm still depressed, since switching to a high carb vegan diet, my mood no longer drops after meals. As a matter of fact my mood seems to improve for a short period after eating a high carb vegan meal before returning to baseline. My baseline state is still low and lethargic but I'm doing much better on low protein vegan diet. So it's not just glutamate but rather maybe related to histamine, serotonin or blood sugar or something else in high protein meals.

sudden mood changes can be caused by head trauma and is especialoy obvious after a meal as food affects brain greatly

Ok, new findings. I think our issue is high glutamate . An inability to get rid of excess glutamate, which results in excitotoxicity, low gaba, high acetylcholine.. which results in major depression. This can be a big breakthrough. I'm going to try following a low glutamate diet and report back in a few weeks before expanding further on this...

 

I suspect more and more based on your observations that the root cause could be high histamine, homocysteine levels and an inability to do proper methylation.

 

Since you have genetic data, can you do the following, which may help?

 

1. have you checked your raw data for MTHFR gene variants, namely C677T and A1298C to determine undermethylation status?   (This link will tell you exactly how to check the raw data to come to conclusion).  Also if you can do a homocysteine test (available in USA by standard labs if you request your physician to write you one), high homocysteine is also an indicator.

2. Have you checked this: Rs1050891: The HNMT gene known as C939T regulates histamine. “AA” will increase histamine.

 

I suffer from undermethylation and have similar symptoms like yours, except that in my case I get crippling fatigue after meals with slight despondency.  I also came to my own conclusion that I cannot get rid of excess glutamate either.

 

Of course, by making above claims, I acknowledge that I am not discussing here how vital of a role gut health plays in all of this, regardless of the above points. 

Edited by Kris111, 20 January 2022 - 01:23 PM.