LONGECITY

OK, my 61 year old sweetheart has been showing some disturbing signs of brain aging.  She's becoming very emotional about current events and can't watch any unpleasantness on TV without running from the room in tears. She has put her lunch bag from work containing only dirty dishes back in the fridge when she comes home.  Popular music from our youth sounds vaguely familiar to her, but she doesn't recognize the group or name of the song.  She's getting clumsy, spilling drinks and such. Plenty of other things, but you get the picture.  

 

She's also had life long trouble with headaches which is a risk factor for dementia, and hearing loss from all the NSAIDs she takes, which apparently is yet another risk factor.  She also does not recognize her decline, which I hear is common in early stage dementia.  Others around her notice, but she does not.  

 

She's slim, active, working full time and eats very healthy (salmon, avocado, smoothies etc), so no lack of mental stimulation or dietary issues.  She takes no prescription meds.  

 

I've got her on Turmeric, SAM-e, Natural Vitamin-e with mixed tocopherols (alternating with mixed tocotrinols), PPC (polyenylphosphatidylcholine), Vitamin-C & D, B-Complex and a probiotic.  Her ferritin is down in the 30s, so she's not deficient or overloaded with iron.  

 

Am I missing anything here? 

 

I'm very concerned about this, as we've got a great retirement ahead of us if we can stay healthy.  I'm posting in supplements as we're already covering all the bases with diet and exercise.  I don't think she's got any organic disease MS, ALS etc, & she's checked out A-OK with her GP/metabolic panel.  

 

Any ideas about what we might add to her stack to slow or stall this disturbing decline?  

Edited by synesthesia, 27 March 2017 - 12:55 AM.

I would look at the VITACOG protocol or Dr. Bredesen's MEND protocol.  Check her homocysteine, MMA levels, B12 levels.  Check blood glucose control, hypertension.  Check her genetics for APOE4 status.  Make sure her sleep is not disrupted and adequate.

 

Only thing I can think of off the top of my head.

Edited by prophets, 27 March 2017 - 01:32 AM.

I would add glycine and perhaps NR. Also some blueberries every day can't hurt, lots of goodies in them. I'm sure others will chime in with suggestions. Read the thread on glycine, there is a link near the end with loads of studies. Glycine is an often overlooked wonder worker. Its cheap and readily available

In one epidemiological study, consumption of tea, especially green but also black and oolong, greatly reduced the chance of dementia even in APOE4 individuals.  The effect was greater with high consumption, but even one cup a week resulted in about a 30% reduction.  It doesn't cure, but may slow progression in individuals showing signs.

 

https://www.google.c...=utf-8&oe=utf-8

 

Nicotinic acid. Seriously, this stuff is gold for multiple age related diseases including cognitive decline. My 71 year old relative is doing much better cognitively after he started taking NA.

I'll add that there is research suggesting fish oil and coffee can also help delay dementia.   There's limited evidence but another potential supplement is magnesium-L-threonate, often sold as magtein

There are many supplements that helps. But you will probably not feel any noticeable effects. The home run drug for neurodegenerative diseases is Niagen. It is reversing my father's Alzheimer's diseases after 4 months of Niagen at 250 mg. I think a higher dose at 500mg is better. It is much easier to prevent Alzheimer's by taking Niagen early in life after 40.

Zink, magnesium, fisetin, pterostilbene, quercetin & Niagen

Thanks for the wonderful response guys/gals.  Lot's to digest here, so I guess I better start doing my homework.  

 

Never thought this would be something I would have to deal with, but every time I think I must be imagining things, she'll surprise me with another bizarre incident.   It took me half a Century to find this gal, & we've been happy for 10 years now.  

 

Thanks again for all your help!  

Exercise.

Fasting. See Mattson's work: https://scholar.goog...bjyAWcQgQMIGDAA

Try fasting, diet with only veg and fruits, and Niagen 250-500mg/day, exercise.

Fasting, exercise, Niagen are similar. But for an old person fasting and exercise are not effective without Niagen.

First, how long have you been aware of these behaviors?

Were it my loved one, before throwing supps at something this (potentially) serious, I'd do a comprehensive hormone panel to rule out hormonal issues.  Then explore potential viruses that affect the brain.  From there, I'd contact a neurologist for a full work-up.

Also, check out:  "The Latest Alzheimer's Research" thread:  http://www.longecity...imers-research/

Sounds like a check up with a neurologist is in order for her.

Better safe then sorry and if theirs something wrong you can find the right supplements and drugs to help yout wife. Vs the broad stroke approach.