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Astragalus Extract - Inflammation and Telomerase

astragalus telomeres telomerase

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#1 Nate-2004

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Posted 24 April 2017 - 10:51 PM


There is a very old thread that was closed so I'm starting a new one on the topic of telomerase activators, specifically around Astragalus but not restricted to it.

 

I was looking through Google scholar on a number of key word searches but I don't see as much research as I'd hoped. Examine recently updated their page on Astragalus Root but are still in the process of compiling all the research.

 

 

Astragalus Membranaceus has just been added to the inventory, and it is a weird one. Among plants, it is unique; among supplements, the body of evidence is also unique.

 

​They also state that:

 

It is a bit unfortunate that the best benefits are seen with such a high dose of root extract (15-30g) as most supplements are geared towards 500mg to 1g. The lower doses give benefit, but this is one of the few supplements that may follow a 'more is better' relationship until your intestines tell you to stop.
 
I decided to try it, as an N=1 experiment, I've been taking nearly 15g a day for the last several days. I bought 250g from Bulk Supplements for a fairly cheap price. The bioavailability is so bad that apparently this is what's needed to absorb anything. Who knows if it's even orally bioavailable at all. Poor is one thing, no bioavailability at all is another. It will only last about 15 days at that rate. I'm basically taking ~4g at a time, 4 times a day.
 
I would love if people could post anything new or recent from 2015 onward if possible. Most of what I'm seeing is more related to its cultivation than its uses. 
 
 

 

 


Edited by Nate-2004, 24 April 2017 - 10:51 PM.


#2 joelcairo

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Posted 25 April 2017 - 04:48 AM

Liposomal astragalus appears to be available from a company called Actinovo.

 

Other than that, my personal belief is that techniques that improve the absorption of other polyphenols could have a similar effect on astragalosides. For example, EGCG is absorbed better when taken without the presence of any protein, and is also stabilized by sugar and by vitamin C or lemon juice. Curcumin and other flavonoids are slightly better absorbed when taken with pepper extract. And so on. You can't know for sure if such techniques work without doing proper studies, but I feel it's likely that at least some of them will help.



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#3 Nate-2004

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Posted 25 April 2017 - 03:15 PM

Liposomal astragalus appears to be available from a company called Actinovo.

 

I see it's outside the US but might ship to the US. Not sure what to think of this. I'm just now learning about liposomal formulations. What do you think about this, is it worth it?



#4 joelcairo

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Posted 25 April 2017 - 03:32 PM

Liposomal formulation has a huge effect on the absorption and stability of many phytonutrients and drugs. This seems to translate into increased biological effect, although I'm not a biochemist and I don't know if such molecules can have much functional effect while encased within the liposome, or if the liposome has to break down first.

 

This can get you into a terra incognita situation where serum levels of astragalosides exceed anything that has been used in traditional medicine. If you're not using this for an acute condition but just for general health and longevity, liposomal astragalus might be too potent to use longterm.



#5 Florian E.

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Posted 25 April 2017 - 09:37 PM

I've recently used the ActiNovo "liposomal Astragoloside IV". At my age, can't tell if it had much of an effect.

 

I also asked ActiNovo what types of liposomes they're using. They use "Phospholipids mainly consisting Phosphatidylcholine.

Not sure if these are the best types to get around digestion and immune system (macrophages).

The digestion problem is pretty much solved with current liposomes afaik.

Their lipsomal glutathione had a tangible effect to me.

But obviously can't tell if "liposomal Astragoloside IV" has helped with telomeres. 

Astragoloside IV includes some amount of Cycloastragenol, which seem to be the telomerase interesting part.

But there  are no studies if liposomal Astragoloside IV (instead of pure cycloastragenol) is enough for a significant telomerase effect.


Edited by Florian E., 25 April 2017 - 09:52 PM.

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#6 Nate-2004

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Posted 25 April 2017 - 09:49 PM

Yeah you're 31 so that's really really hard to tell, way too young at this point but who knows? I may try a 250ml bottle or two. It says take 10ml or so at a time, which... not sure how many times a day I'd do that. Maybe later, in another cycle, after I finish this batch of plain powder extract.



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#7 Florian E.

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Posted 25 April 2017 - 09:56 PM

Yeah you're 31 so that's really really hard to tell, way too young at this point but who knows? I may try a 250ml bottle or two. It says take 10ml or so at a time, which... not sure how many times a day I'd do that. Maybe later, in another cycle, after I finish this batch of plain powder extract.

 

I only took short (10 day) cycle / 10ml day. The larger bottle alcohol version is more durable and has a less "noticeable" taste.







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