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A Womanly Antidepressant

antidepressant serotonin 5-htp women

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#1 jroseland

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Posted 28 July 2017 - 12:17 PM


As I perused Youtube and the Biohacker forums I noticed a bit of a trend; 5-HTP is quiet popular with women and seems to be a real godsend of tranquility for many of them. Has anyone else noticed this trend?
 
Princess Joules here on Youtube typifies the average woman singing the praises of 5-HTP
Of the few ancedotal accounts that were unfavorable of or had a bad experience with 5-HTP, none were women.
Men and women have different types of minds, IQ research has shown that women very vary little from the mean relative to men. 
gite01.jpg
If you're a woman it's more likely that a Biohack will work for you if it generally works for other women than if you were man, statistically speaking.
Evolutionary psychology manifests as women's proclivity towards anxiety and insecurity. 5-HTP seems to a good option for members of the fairer sex to sail smoothly through the rough seas of life with grace and elegance.

Edited by jroseland, 28 July 2017 - 12:18 PM.

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#2 PeaceAndProsperity

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Posted 28 July 2017 - 11:43 PM

Several female personality traits are mediated via serotonin receptors, and estrogen increases serotonin receptor expression. So I assume it boils down to that somehow.

Men prefer "drugs" that induce neurotransmission of the same neurotransmitters that cause male personality traits and women tend to prefer the opposite.

 

I've also noticed that people with female-like personality disorders like borderline personality disorder tend to prefer a specific type of drugs (psychedelics) over other types. I've noticed this with multiple diseases.

 

Now preference and reaction to is sort of the same here... :|?

 


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#3 gamesguru

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Posted 29 July 2017 - 02:50 PM

really depends on the dose as well.  20mg may be invigorating, but 200mg for guys is more like salt petre.. increasing levels of anxiety in conjunction with the 5-HT2C regime.  anxiety is a less of a factor for women (both appetitive and consummate) and so we expect serotonin should be less problematic for them.  indeed for them the research is centered around 5-HT2A.  however if you increase the serotonergic binding sufficiently, women will also get cold feet at the 2C site.  once i was at a party and everyone was tripping, except me.  now usually girls latch onto me like a barrel of monkeys, but this particular night i went home alone.  acid makes the ladies behave very strangely indeed.  more interesting is the inhibitory effect of marijuana, which i think is due to GABA activity, a prominent factor in female sexuality.  so it's something alcohol has to offset, through secondary mechanisms like oxytocin.  another thing to consider here is that the brain regions on which the dopamine release is mediated also differ between the two drugs, alcohol affects the more primal hypothalamus [consummate] and pituitary which control hormone response  while marijuana affects moreso the mesolimbic pathways (e.g. VTA, substantia nigra and accumbens [desirous], which are sexually dimorphic in mammals.. ie. they have opposite effects on men and women.  VTA in particular you can find lots of studies for differential effects)

 

my views on serotonin have been shaped much like ScienceGuy's were on GABA.  too much is bad.  i get a normal amount of tryptophan, but don't take bacopa or lithium or go out of my way to promote TPH2, inhibit MAO, etc etc.  i've had better results with stuff like green tea, grapefruit, pinto beans and ginger, stuff that a guy on the street wouldn't suspect, but stuff that has weakly serotonin modulating properties in addition to  far-reaching effects on everything from differentiation of the micro-vasculature to inhibition of mitochondrial mutation.  kind of sad that everyone reaches for 5-htp after a rave and not something more natural, but hey that's not my problem.  i don't even attend those zombie fests


Edited by gamesguru, 29 July 2017 - 02:53 PM.

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#4 PeaceAndProsperity

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Posted 29 July 2017 - 06:33 PM

^The "women" you find at parties don't classify as women. They're flat chested, probably have the estrogen levels of a bodybuilder (low for a woman). They're men in all sense of the word except you know..


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#5 gamesguru

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Posted 29 July 2017 - 07:50 PM

men also are attracted to me, nobody's denying that.  but are you actually suggesting girls would have bigger boobs if they took 5-htp?  you're so naive, are you still reading those woman's magazines?  sometimes in reading your posts i gather the impression that you wish to kill yourself after comparing your intellect to mine.  i didn't say 5-htp was bad for girls, or wouldn't restore homonal balance when used IN MODERATION, i simply pointed out how abusing it would have a pro-anxiogenic effect and how there were other choice, i.e. green tea 7 cups   :sleep:

 

and sure, a tiny portion of these club rats, these nasty detroit hos ARE flat chested but that's either cause they're super fit or their parents didn't know how to feed them.  either way it sounds like a personal problem for them not me or you.

 

furthermore, there are not many differences in personality among the sexes.. you might say oh she's a bitch or he's so intuitive, but you're just commenting on individual traits.. how many of these qualities when you boil everything down can you ascribe essentially to womanhood?  and those differences which do exist are generally very deeply ingrained (though not major differences, they can be expressed in the minutest subtly), so hormonal changes are generally unlikely to push personality in the direction of the opposite sex.  that's one reason why testosterone injections do not cure men of their homosexuality, their unwillingness to get their hands dirty.  same thing if you give straight guys estrogen injections perhaps their inability to sit around and just talk like girls do, or to look beyond appearances in a mate as girls do will be restored?  but no, just no.


Edited by gamesguru, 29 July 2017 - 08:02 PM.

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#6 Deaden

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Posted 30 July 2017 - 08:44 AM

This was definitely entertaining to read ^^'


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#7 AOIministrator

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Posted 11 August 2017 - 12:45 PM

Women are a shitmagnet if it comes to science. Their whole reality isn't build bottom up from direct experience and logic, but from copying and re-identifying scrambled bits and parts of the opinions and perceptions of others, that are already considered as socially adequate within their limited understanding and social circle. Women are easily fooled by authority, such as medical authority, ultimately rooting in the desire to be subjugated by the penis. They have smaller brains and only god knows why he made men suffer so much from trying to understand them.

 

All combined, they wrack their bodies with contraceptive hormones while praising them, and believe they get cancer if they order healthy medication on their own online.

 

Comparably infinitely inert stuff like apple cider vinegar or chocolate have been trending since ages. And 5-HTP is nothing more than the new super-scientificy version of chocolate.

 

Women are emotional thinkers. They love placebo drugs, and they hate the drug the more so it was a nocebo.

 

Don't understand me wrong, women have a place in science. Namely if they are told what to do.


Edited by AOIministrator, 11 August 2017 - 12:54 PM.

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#8 jroseland

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Posted 12 August 2017 - 08:41 AM

I've also noticed that people with female-like personality disorders like borderline personality disorder tend to prefer a specific type of drugs (psychedelics) over other types. I've noticed this with multiple diseases.

 

4_men-vs-women.jpg

Source


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#9 jroseland

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Posted 12 August 2017 - 08:50 AM

Women are emotional thinkers. They love placebo drugs, and they hate the drug the more so it was a nocebo.

Oh... you're such a sexist. The ladies must love you. You're probably receiving fellatio at this very moment.

 

This was definitely entertaining to read ^^'

Thanks!

 

^The "women" you find at parties don't classify as women. They're flat chested, probably have the estrogen levels of a bodybuilder (low for a woman). They're men in all sense of the word except you know..

Trolling... Always trolling...

 

really depends on the dose as well.  20mg may be invigorating, but 200mg for guys is more like salt petre.. increasing levels of anxiety in conjunction with the 5-HT2C regime.  anxiety is a less of a factor for women (both appetitive and consummate) and so we expect serotonin should be less problematic for them.  indeed for them the research is centered around 5-HT2A.  however if you increase the serotonergic binding sufficiently, women will also get cold feet at the 2C site.  once i was at a party and everyone was tripping, except me.  now usually girls latch onto me like a barrel of monkeys, but this particular night i went home alone.  acid makes the ladies behave very strangely indeed.  more interesting is the inhibitory effect of marijuana, which i think is due to GABA activity, a prominent factor in female sexuality.  so it's something alcohol has to offset, through secondary mechanisms like oxytocin.  another thing to consider here is that the brain regions on which the dopamine release is mediated also differ between the two drugs, alcohol affects the more primal hypothalamus [consummate] and pituitary which control hormone response  while marijuana affects moreso the mesolimbic pathways (e.g. VTA, substantia nigra and accumbens [desirous], which are sexually dimorphic in mammals.. ie. they have opposite effects on men and women.  VTA in particular you can find lots of studies for differential effects)

Interesting yeah Gabaergics seem to make the ladies a lot more fun...


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#10 PeaceAndProsperity

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Posted 12 August 2017 - 02:20 PM

 

I've also noticed that people with female-like personality disorders like borderline personality disorder tend to prefer a specific type of drugs (psychedelics) over other types. I've noticed this with multiple diseases.

 

4_men-vs-women.jpg

Source

 

Interesting but just not true. Men who take male hormones ("steroids") obviously tend to abuse drugs like stimulants but the drugs they very rarely touch are hallucinogens.

What type of people are known to abuse hallucinogens? Hippies. Are hippies feminine or masculine? Obviously feminine. You will find countless examples of this. Hallucinogens appeal to women and and feminine types more than men.

 

Why the hell does the chart list the same type of drug (sedatives) multiple times

 


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#11 AOIministrator

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Posted 12 August 2017 - 07:25 PM

LSD is obviously a drug heavily used in gay clubs, hence the botched statistics.


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#12 gamesguru

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Posted 13 August 2017 - 01:53 PM

once i walked into a gay bar on accident and somebody slapped a tenstrip on my tongue.  i just spat it out and told him it taste like some sour patch extreme.   i run home and two hours go by, i think nothing of it as i work on the computer, but suddenly i'm lifted by the seat of my heels on a trip that will last for days.  one of the wonkiest substances known to man.  DOB with a slight chance of bromo dragonfly.  thankfully it's just a story.  but the day after a REAL trip, i was having my oil changed and found myself admiring a guy across the lobby.  between his sockless 500 dollar shoes, skintight slacks and alligator watch, his tame beard and supple head of hair, and his all leather macbook purse i couldn't help but stealing glances in his direction.  i'm not sure if i was admiring his level of discipline or he himself


Edited by gamesguru, 13 August 2017 - 01:58 PM.

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#13 jroseland

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Posted 14 August 2017 - 12:40 PM

As always Longecity is a den of cheeky yet clever bastards

 

New podcast meta analyzing the 5-HTP studies, trials and Biohacker reports


Edited by jroseland, 14 August 2017 - 12:42 PM.

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