15 replies to this topic

[Arkay]

Hi,

 

Since 6-7 years I have a mind-body perception alteration that expresses itself as a depersonalization-derealization syndrome, as it is called. I have many different symptoms, but I won't explain them here cause there is no need to emphasize on them, you can find them on the Internet (if you ask I can tell them of course).

For years I reached many doctors and many practictioners (from alternative medicine to "modern" medicine, from mind approch to body approch) and none of them could provide me for a treatment nor the relief of the symptoms. They say for now we don't have the technology to observe precisely deep into the brain what is taking place at the neuronal-chemical level. I already tested rTMS on the right angular gyrus during three weeks... nothing happened.

 

I place my hope in futur technologies like AIs, better brain knowing, etc.

Do you know a means to reach the WATSON AI team to see what it could do for me?

Or have you any idea of whom I should adress to? Are there groups of geniuses over there working secretly in there garage that could see deep in my brain what is going on and cure it?

 

I can barely believe that in 2017 we don't have yet the capacity the see deep in the brain what is going on the chemical and electrical level or whatsoever, and to find a cure...

 

Thanks for reading me (sorry for my english), and for what you could do.

Maybe I am not in the right place to ask for help... in this case could you provide me with links to forums or organizations that know more about the brain than most people?

I am ready to experiment a lot. I consider myself a "pending being", I am not really living...

 

I was told "Stinkorninjor" knew a good treatment for dp-dr (thanks Deaden).

 

Anyways,

Have a good day.

 

Victor

[Mind_Paralysis]

I don't know if I truly know of a good treatment for DP/DR, but I might know the best ones available at the moment, given what little we know of the phenomena.

 

What are all of your diagnoses, exactly? What drugs have you tried?

 

Did your DP/DR come around "naturally", as a result of emotional trauma (people who got war and get shell-shocked get this, as well as people whom are raped - it's possibly a survival mechanism) or did you get it via abuse of drugs? NMDA-antagonists are known to cause this issue in some people - Ketamine, Memantine, DXM, et c. There is also some reports of the opioid herb Salvia and Ibogaine triggering it as well - through KAPPA-agonism.

 

Anyways, the data we have support the use of compounds which modulate glutamate activity and opioid activity, so, as such:

 

Lamotrigine (lamictal, e c) - glutamate modulator

NAC - glutamate modulator

 

CERC-501 - kappa antagonist

JDtic - kappa antagonist

Buprenorphine/naltrexone - kappa antagonist, there are other buprenorphine combinations as well, which might be better, hard to tell. This sort of combo is bound to be the most available and even prescribable kappa antagonist you're going to find.

 

https://en.wikipedia...hine/naltrexone

 

 

In theory, since they affect glutamate too, Tianeptine and Modafinil could be useful as well. Modafinil only works if you also have attention-problems, so don't use it unless you've got problems focusing as well - there are no robust studies on it either, it's just something that certain Dr's claim works for a subset of people with DP/DR.

 

CERC-501 is available through a group buy I was a part of - simply contact the user Brighterpath and ask him to hook you up. I myself used the drug and found that it has effects - I do not, however, have DP/DR, so I can't vouch for any such effects. It should be mentioned that 1/3'rd of all DP/DR-sufferers do not seem to respond to kappa-antagonism, and instead need a purely glutamatergic action.

 

 

I'd supply the necessary references, but I can feel the SCT-block coming in, it's pointless to even try to find the links now. BUT - hopefully you'll be inspired to find the data yourself and come to your own conclusions.

[Arkay]

I got dp-dr following a LSA (HBW) intake (it was the first time I took drugs). I got a bad trip when I saw in the mirror that my eyes were a little bit convulsed and I didn't quite recognized myself very well. At this moment I was panicked by it and fainted. I think  dp-dr symptoms are the traces of this strong pic of anxiety. So I try to "reprogram" the brain by looking at my eyes in the mirror and cultivating a serenity feeling, but for now I didn't managed to do it. Maybe I am completely mistaking but you know, we have to try several potential solutions.

I tried fluoxetine, lamotrigine, naltrexone... it did nothing or made me feel more exhausted than I already was. But I tried one at a time and at "normal" doses.

I feel like my brain is completely non receptive to any chemical substance. I have some attention problems but I think they are consequences of exhaustion, high fatigue. I feel lost between all these substances... You think I should carry on testing them one at a time, but at high doses, until finaly one has positive effects on me ?

 

[Mind_Paralysis]

I'm amazingly tired right now.

 

I think you should talk to your Dr. about using the legal substances at least, like Lamotrigine. SSRI's may not have the same good effect, even though they do have SOME evidence of helping with the issue at hand.

 

Interesting note that you actually know what caused your DP/DR - LSA, you say? Apparently closely structurally related to LSD... do you know anything about it's pharmacology? Is it a serotonin-agonist, similar to LSD? How does it cause its mind-altering actions?

 

Perhaps you could trace the effects of LSA, and then use drugs which work PERFECTLY, or close enough, in reverse of it, to reverse the symptoms?

 

 

I don't know which doses you used with Lamotrigine? Dosing, as well as time, could be issues here. It should also be noted, that Naltrexone may not necessarily have the correct effects unless combined with Buprenorphine, in order to get a selective Kappa-blocking cascade going - try it again, but with Buprenorphine this time - and remember that the dosing needs to be precisely right, or it won't be a Kappa-antagonist...

 

That, or use CERC-501.

 

 

There's also the idea of combining CERC-501 and Lamotrigine, which is admittedly a completely untested combo.

Edited by Stinkorninjor, 08 September 2017 - 02:18 PM.

[Deaden]

I got dp-dr following a LSA (HBW) intake (it was the first time I took drugs). I got a bad trip when I saw in the mirror that my eyes were a little bit convulsed and I didn't quite recognized myself very well. At this moment I was panicked by it and fainted. I think  dp-dr symptoms are the traces of this strong pic of anxiety. So I try to "reprogram" the brain by looking at my eyes in the mirror and cultivating a serenity feeling, but for now I didn't managed to do it. Maybe I am completely mistaking but you know, we have to try several potential solutions.

I tried fluoxetine, lamotrigine, naltrexone... it did nothing or made me feel more exhausted than I already was. But I tried one at a time and at "normal" doses.

I feel like my brain is completely non receptive to any chemical substance. I have some attention problems but I think they are consequences of exhaustion, high fatigue. I feel lost between all these substances... You think I should carry on testing them one at a time, but at high doses, until finaly one has positive effects on me ?

 

It's good you're doing the right thing, keep trying, keep looking for answers! This may be like a stupid question, but have you tried meditation? I believe it's very good for DP/DR, but you need to be consistent with it as much as you possibly can.

[Deaden]

 

I got dp-dr following a LSA (HBW) intake (it was the first time I took drugs). I got a bad trip when I saw in the mirror that my eyes were a little bit convulsed and I didn't quite recognized myself very well. At this moment I was panicked by it and fainted. I think  dp-dr symptoms are the traces of this strong pic of anxiety. So I try to "reprogram" the brain by looking at my eyes in the mirror and cultivating a serenity feeling, but for now I didn't managed to do it. Maybe I am completely mistaking but you know, we have to try several potential solutions.

I tried fluoxetine, lamotrigine, naltrexone... it did nothing or made me feel more exhausted than I already was. But I tried one at a time and at "normal" doses.

I feel like my brain is completely non receptive to any chemical substance. I have some attention problems but I think they are consequences of exhaustion, high fatigue. I feel lost between all these substances... You think I should carry on testing them one at a time, but at high doses, until finaly one has positive effects on me ?

 

It's good you're doing the right thing, keep trying, keep looking for answers! This may be a stupid question, but have you tried meditation? I believe it's very good for DP/DR, but you need to be consistent with it as much as you possibly can.

 

 

[Arkay]

It's good you're doing the right thing, keep trying, keep looking for answers! This may be like a stupid question, but have you tried meditation? I believe it's very good for DP/DR, but you need to be consistent with it as much as you possibly can.

 

In fact I practiced Vipassana meditation a lot a few years back (Goenka 10-days courses, ten hours a day so quite "consistent"). It was awesome, I found what I looked for spiritualy speaking, but now with my dp-dr I can't meditate anymore, and this is so sad. It may be difficult to accept/understand, but in meditation we use the awareness of sensations, and with dp-dr I lost almost lost all of that sharp-edge awareness of sensations, so I can't do the meditation exercices... I am so disconected from my body and sensations that my meditating trials now are just like going around in circles, like a motor running without oil. I would be surprised if someone with dp-dr could meditate and benefit from it.

Edited by Arkay, 08 September 2017 - 04:08 PM.

[Deaden]

 

It's good you're doing the right thing, keep trying, keep looking for answers! This may be like a stupid question, but have you tried meditation? I believe it's very good for DP/DR, but you need to be consistent with it as much as you possibly can.

 

In fact I practiced Vipassana meditation a lot a few years back (Goenka 10-days courses, ten hours a day so quite "consistent"). It was awesome, I found what I looked for spiritualy speaking, but now with my dp-dr I can't meditate anymore, and this is so sad. It may be difficult to accept/understand, but in meditation we use the awareness of sensations, and with dp-dr I lost almost lost all of that sharp-edge awareness of sensations, so I can't do the meditation exercices... I am so disconected from my body and sensations that my meditating trials now are just like going around in circles, like a motor running without oil. I would be surprised if someone with dp-dr could meditate and benefit from it.

 

I see... yeah must be hard. I don't know I read a few forum post of people curing their DP from meditation, maybe it's hard but possible? I don't know might be ignorant for me to say that. Anyway a friend of mine is trying a detox program for his anhedonia (not DP) and he shared me that link :http://www.curezone....m.asp?i=2004032 This post is from someone who cured his DP/DR thanks to detox... it's possible it could help you as well. Is there some levels of depersonalization severity? Would you say yours is very severe? All I know is if dissociation is indeed the route cause of your problems, then it's technically possible for you to get out of it, though it's not easy at all.

Edited by Deaden, 08 September 2017 - 04:36 PM.

[Arkay]

LSA, you say? Apparently closely structurally related to LSD... do you know anything about it's pharmacology? Is it a serotonin-agonist, similar to LSD? How does it cause its mind-altering actions?

As far as LSD is concerned, aparently it increases serotonin, glutamate and dopamin. But the dp-dr effects are rather the oposite... so what drug-effect should I focus on?

 

I don't know which doses you used with Lamotrigine?

 

I don't remember the dose, the "standard" one I think, one pill during 6 weeks I think. But given that it didn't have effects, I am not very in testing it again... So much substances "to test", I feel lost... And I saw many people saying that they tested dozens and dozens of drugs with no success... This is not very motivating.
 

[Arkay]

I read a few forum post of people curing their DP from meditation, maybe it's hard but possible?

I did another 10-days course with my dp-dr, and it had no effects... whereas the first course (when I had not so much dp-dr) had amazing effects.
 

This post is from someone who cured his DP/DR thanks to detox...

I feel like testimonials saying they cured their dp with "sports + good diet" are very weird... These advices apply to everyone! It's not a "bad mood" I have, it's a whole perceptions alteration. I eat organic and vegetarian most of the time , I try to do sport 3 times a week... But I feel no changes.
 

Is there some levels of depersonalization severity? Would you say yours is very severe?

Yes there are "depersonalization scales", let's say mine is average.

[Deaden]

10 days? It sounds a little bit short you should do more...or maybe start doing yoga, it's not like you have anything to lose. Yes you have a whole perception alteration, but I think from what I've read about DP you need to ignore it the more you can and try to live as connected to reality as you can until you make progress long term. Even if it sounds completely unnatural, keep going. At the same time try the drugs Stinkorninjor mentioned, you can also research what other medications helped for people with the same symptoms as you and try to get your hands on them. I just read MAOIs can be helpful for some, have you tried those? I'd say do research and try anything that you read can help and don't waste your time with any random medication your psychiatrist thinks you could try. If he's not knowledgable on DP, then it's to you to say what you want to test out. Anything that people who had the same symptoms say helped, do it. Don't lose hope, dissociation is not permanent damage to the brain. Just keep on with trial and error like I said you have nothing to lose.

 

Ah tu es Français Moi aussi, et Américain

Edited by Deaden, 08 September 2017 - 05:52 PM.

[Arkay]

Mh, you know ten hours a day of meditation during ten days in a row it's a lot xD it is very intense, trust me it is enough to learn the technique, feel the results and be able to practice on your own after the course But we are getting away from the subject.

Oui je suis français ^^

[ThreeKings12341]

This post is from someone who cured his DP/DR thanks to detox...

I feel like testimonials saying they cured their dp with "sports + good diet" are very weird... These advices apply to everyone! It's not a "bad mood" I have, it's a whole perceptions alteration. I eat organic and vegetarian most of the time , I try to do sport 3 times a week... But I feel no changes.

 

 

its not about sports and good diet in that thread. the main important thing is to detox your body from those heavy metals which have found somewhere a place to live in your body over the years.

 

i started detoxing with easy stuff and now added  chlorella (2day  is day 32 or something)  first days i started was really crap for me : really lethargic, grumpy etc. but on the 4th day of detoxing i stopped  my compulsive skin picking disorder and im still not skinpicking and i had that disorder for more than 15 years. - and as you see its not the mind, its those toxic metals.

but i feel my body is doing something everyday because i dont feel stable as i used 2 its now more a roller coaster even though im detoxing in a gentle way...

 

ive read in many german forums also that they felt like a normal human when they did their first intake with dmsa (chelation form). and that gives me even more hope..

[Arkay]

Ok thanks, so I am going to try chlorella when I receive it.

I will begin at 500mg and go to approx. 5g. It is said to take higher doses if bad effects occur.

[Deaden]

Bonne chance

[Arkay]

Merci ^^