Also wanted to ask whether you take some meds alongside? I saw you posted somewhere about being on lexapro some time ago. I'm also taking it and interested in some possible interactions.
Lexapro 20mg. No interaction at all. Since I started taking Mife 300mg in the morning I actually feel that if I miss one day of lexapro it is not the end of the world. Before I would feel very tired and sluggish. However one day is too short to assess whether Mife might reduce the SSRI withdrawal effects, especially considering the lexapro relatively long half-life.
The first week I was taking Mife I could feel a slight increase of edginess/nervous tension in my neck but at the same time I did not feel the need to go back to sleep after a couple of hours waking up in the morning. Daytime sleepiness has always been one of my issues.
After the first week, however, I do not feel any side effects after taking Mife in the morning and daytime sleepiness and that constant feel of edginess/stress in the morning is gone. I feel almost like I feel late at night when my anxiety/stress vanishes.
Once I tried 600mg but my nervous tension was a bit too high and considering I have a supply for a month at 300mg a day I decide not to keep it up. Before trying with Mife I also tried for a month low dose naltrexone (around 2/3 mg instead of 4.5mg at night) in order to increase beta endorphins which have strong counter effect on stress. For now, with the combination of the two regimens, I feel like I have not felt for a long time. I just hope when I finish my Mife supply in a couple of weeks I do not slowly go back to square one and it has produced long lasting effects.
Long term side effects of Mife can only be assessed by people suffering from Cushing syndrome and using Mife as their main treatment. So I am not sure what they could be. Being Mife a progesterone antagonist I guess any side effect could come from reduced progesterone levels. After two weeks I cannot notice any issue. I just know that it is reccommended to supply potassium to counteract Hypokalemia when using Mife. That is what I am doing.
If you suffer from depression or Generalized Anxiety Disorder due to stress and possibly high cortisol levels I guess Mife and LDN regimens could be an avenue to explore.
These are two interesting article I found on the subject of CRH which is the first step (then ACHT, then cortisol) in the production of cortisol:
On the role of corticotropin-releasing hormone receptors in anxiety and depression
https://www.ncbi.nlm...les/PMC3181666/The CRF System as a Therapeutic Target for Neuropsychiatric Disorders
https://www.ncbi.nlm...les/PMC5121012/Through some research I found the following supplements could help to reduce CRH, ACHT and cortisol:
Step 1) Reduce CRH
- Quercetin
Source:
https://www.ncbi.nlm...pubmed/20447436- Antalarmin
Source:
https://en.wikipedia...mone_antagonistSource:
https://www.ncbi.nlm...les/PMC1315297/- Pexacerfont
Source:
https://en.wikipedia...mone_antagonistSource:
https://www.ncbi.nlm...les/PMC4367465/Step 2) Reduce ACHT
- Mirtazapine
Source:
https://www.ncbi.nlm...pubmed/18926641Step 3) Reduce Cortisol
HSD11B1 inhibitors:
- Epigallocatechin gallate (EGCG, green tea extract)
Source:
https://www.ncbi.nlm...pubmed/24404164Quote: "Consequently, major polyphenolic compounds from green tea, in particular catechins were tested with the same systems. (-)-Epigallocatechin gallate (EGCG) revealed the highest inhibition of 11ß-HSD1 activity (reduction: IC50?=?57.99 µM; oxidation: IC50?=?131.2 µM)"
- Phosphatidylserine
Personally I had a great response to both supplements. However phosphatidylserine dosage must be much higher than the average supplements on the market. At least 300mg but even better 600mg and up to 1000mg per day. Being Phospha being very expensive Alibaba is a way to explore.
Edited by world33, 10 April 2018 - 12:01 AM.
