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Noob need help understanding vasorelaxation part of a C60 study

vasorelaxation c60 endothelium vasoconstriction

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#1 Al4ina

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Posted 03 December 2017 - 06:02 PM


Ok so I am being stupid here but I can’t figure this out. I read someone on this forum say the following about C60:

 

http://www.longecity...ts-home/page-10

 

“Another interesting article, dealing with atherosclerotic rats, C60 in saline solution and resulting in vasomotor balance shift towards vasorelaxation:
https://particleandf...6/1743-8977-6-5

 

 

 

I check the study and find this:

 

“The aged apoE-/-mice had lower endothelium-dependent vasorelaxation elicited by acetylcholine in aorta segments mounted in myographs and the phenylephrine-dependent vasoconstriction response was increased. One hour after an intraperitoneal injection of 0.05 or 0.5 mg/kg of C60 fullerenes, the young apoE-/- mice had slightly reduced maximal endothelium-dependent vasorelaxation. A similar tendency was observed in the old apoE-/- mice. Hampered endothelium-independent vasorelaxation was also observed as slightly increased EC50 of sodium nitroprusside-induced vasorelaxation response in young apoE-/- mice.”

1.png

The SNP-induced vasorelaxation was shifted toward a reduced responsiveness in young apoE-/- mice treated with 0.5 mg/kg of C60 fullerenes compared with the 0 mg/kg exposed group (figure 4, table 1). This was evident from the EC50 value (16.5 nM (95% CI: 13.4–20.3 nM) which was significantly increased compared to the control group (10.1 nM (95% CI: 8.1–12.6 nM). The EC50 for mice treated with the lower dose was slightly increased (15.7 nM (95% CI: 11.2–22.0 nM), although this was not statistically significant at a 5% level.

 

2.png

 

 

My brain simplifies it like this

When the scientist tried to force vasorelaxation with acetylcholine then:

·        vasorelaxation was lower (as in less relaxed) with C60 than without

·        vasoconstriction was higher (as in more constricted) with C60 than without

When the scientist tried to force vasorelaxation with sodium nitroprusside (SNP) then:

·        vasorelaxation was slightly lower (as in less relaxed) with C60 than without

 

So how does this mean that “vasomotor balance shifts towards vasorelaxation”? I know sometimes stuff appears to decrease stuff while it actually increases them. For example, when you first hear the word Selective Serotonin Reuptake inhibitor (SSRI), as a normal person you can easily believe that this means that Serotonin will be inhibited as in decreased. But as everyone a little educated knows Serotonin in this case will actually increase, at least temporarily. So I  thought that maybe something similar that I’m missing is in place with this vasorelaxation thing. On the other hand, maybe the forum guy is just wrong, mystery solved?



#2 apmark

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Posted 10 December 2017 - 12:38 PM

the serotonin is not really increased by an ssri. It is because the nueron synapses wont accept it so it is stuck in between synapses and builds up there as it cannot pass



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#3 Turnbuckle

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Posted 12 December 2017 - 12:56 PM

This study is of small particles and is not relevant to dissolved C60.







Also tagged with one or more of these keywords: vasorelaxation, c60, endothelium, vasoconstriction

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