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Topical rapamycin to prevent photo-aging (by Blagosklonny)

blagosklonny rapamycin photo-aging aging topical rapamycin

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#1 BRIGHT

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Posted 27 January 2018 - 08:37 AM


Quote from new 2017 PMC article by Blagosklonny: "by reducing cellular senescence, rapamycin may be considered to prevent photo aging. Rapalogs (rapamycin and everolimus) can be used not only systemically but also topically. Rapalog-based creams are expected not to interfere with sun tanning and vitamin D3 synthesis."

 

Let's discuss :)

 

REFERENCE: https://www.ncbi.nlm...les/PMC5752566/


Edited by BRIGHT, 27 January 2018 - 08:38 AM.

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#2 recon

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Posted 28 January 2018 - 09:12 PM

Interesting. I’m sure the folks over at the Ageless Looks subforum will appreciate the news more.

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#3 BRIGHT

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Posted 07 December 2018 - 02:38 PM

Moved to Ageless Looks subforum - https://www.longecit...y-blagosklonny/


Edited by BRIGHT, 07 December 2018 - 02:39 PM.


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#4 smithx

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Posted 08 December 2018 - 04:53 AM

There was also a recent thread about a 100uM solution of azithromycin in vitro killing 97% of senescent fibroblasts, so my idea is to:

 

- First use azithromycin to kill the senescent cells

- Then use rapamycin to preserve the remaining cells

 

I made an azithromycin in 95% ethanol solution today and am applying it only to my left outside eye region (which is actually more wrinkled than the right for some reason) to see if there's a noticeable difference in a week.

 

After that I will make a 5nM solution of rapamycin and apply that. (I just happened to have both of these componds in the freezer).

 

But I wonder if the rapa should be applied intermittently (once a week or so) the same way it's best to dose it.

 

Thoughts?



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#5 BRIGHT

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Posted 08 December 2018 - 06:32 AM

There are some articles out there if you search pubmed for "topical rapamycin"

 

For example this study (https://www.ncbi.nlm...les/PMC3573457/) found topical sirolimus 1% to be more effective than 0.1%. It was applied nightly for 6 months.

Table 1. Topical rapamycin used for treatment of facial angiofibromas
 
IDOJ-4-54-g002.jpg
 

 


Edited by BRIGHT, 08 December 2018 - 06:33 AM.






Also tagged with one or more of these keywords: blagosklonny, rapamycin, photo-aging, aging, topical rapamycin

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