• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
              Advocacy & Research for Unlimited Lifespans

- - - - -

Topical rapamycin to prevent photo-aging (by Blagosklonny)

blagosklonny rapamycin photo-aging aging topical rapamycin

  • Please log in to reply
4 replies to this topic


  • Guest
  • 13 posts
  • 7
  • Location:London

Posted 27 January 2018 - 08:37 AM

Quote from new 2017 PMC article by Blagosklonny: "by reducing cellular senescence, rapamycin may be considered to prevent photo aging. Rapalogs (rapamycin and everolimus) can be used not only systemically but also topically. Rapalog-based creams are expected not to interfere with sun tanning and vitamin D3 synthesis."


Let's discuss :)


REFERENCE: https://www.ncbi.nlm...les/PMC5752566/

Edited by BRIGHT, 27 January 2018 - 08:38 AM.

  • Informative x 3
  • like x 2

#2 recon

  • Guest
  • 192 posts
  • 25
  • Location:left blank

Posted 28 January 2018 - 09:12 PM

Interesting. I’m sure the folks over at the Ageless Looks subforum will appreciate the news more.

sponsored ad

  • Advert
Click HERE to rent this advertising spot for AGELESS LOOKS to support LongeCity (this will replace the google ad above).


  • Topic Starter
  • Guest
  • 13 posts
  • 7
  • Location:London

Posted 07 December 2018 - 02:38 PM

Moved to Ageless Looks subforum - https://www.longecit...y-blagosklonny/

Edited by BRIGHT, 07 December 2018 - 02:39 PM.

#4 smithx

  • Guest
  • 1,204 posts
  • 351

Posted 08 December 2018 - 04:53 AM

There was also a recent thread about a 100uM solution of azithromycin in vitro killing 97% of senescent fibroblasts, so my idea is to:


- First use azithromycin to kill the senescent cells

- Then use rapamycin to preserve the remaining cells


I made an azithromycin in 95% ethanol solution today and am applying it only to my left outside eye region (which is actually more wrinkled than the right for some reason) to see if there's a noticeable difference in a week.


After that I will make a 5nM solution of rapamycin and apply that. (I just happened to have both of these componds in the freezer).


But I wonder if the rapa should be applied intermittently (once a week or so) the same way it's best to dose it.




  • Topic Starter
  • Guest
  • 13 posts
  • 7
  • Location:London

Posted 08 December 2018 - 06:32 AM

There are some articles out there if you search pubmed for "topical rapamycin"


For example this study (https://www.ncbi.nlm...les/PMC3573457/) found topical sirolimus 1% to be more effective than 0.1%. It was applied nightly for 6 months.

Table 1. Topical rapamycin used for treatment of facial angiofibromas


Edited by BRIGHT, 08 December 2018 - 06:33 AM.

Also tagged with one or more of these keywords: blagosklonny, rapamycin, photo-aging, aging, topical rapamycin

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users