Well I think that the average CRer starting at around 20 - 30 years could probably expect to easily reach 100 assuming they're not unlucky and have terrible genetic predisposition to disease. Otherwise it could just normalize life span which is good thing in it self !
I think the average age reached by long term CR would be around 110-115 years if starting at a young age. Our aging process will have been slowed and disease risk diminished that of the what we see in Super Centenarians of today... the characteristics that help a person become a super centenarian are probably present in CRers.
There is no doubt we can alter the process of aging in mice, you get two groups of genetically identical mice and calorie restrict one of them. The genes already present in an organism can allow for a nice extension of lifespan. I think max lifespan in humans could probably be extended to about 130 years, I think being very optimistic 135-140.
There was one study in Rhesus Monkeys that you might find interesting, the CR group lived on average to 32 years, but were mostly obesity avoidance group. The average Rhesus monkey lives anywhere from 25 - 27 years, similar lifespan to an ad lib humans ( 75 - 81 years). The CR group in this study lived to a human equivalent of 96 human years. This is impressive I think. It has been estimated that humans on an ad lib healthy-ish diet could live on average to 85 - 90 years WITHOUT CR. It will be very interesting to see just how the real anti aging CR diet monkeys do.
This study below showed that CR Monkeys gained 7 years of extra life which is equivalent to humans gaining 21 years of extra life.
Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction
Noni L. Bodkin1, Theresa M. Alexander1, Heidi K. Ortmeyer1, Elizabeth Johnson2 and Barbara C. Hansen1
1 Obesity and Diabetes Research Center, Department of Physiology, School of Medicine, University of Maryland, Baltimore.
2 Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland.
Mortality and morbidity were examined in 117 laboratory-maintained rhesus monkeys studied over approximately 25 years (8 dietary-restricted [DR] and 109 ad libitum-fed [AL] monkeys). During the study, 49 AL monkeys and 3 DR monkeys died. Compared with the DR monkeys, the AL monkeys had a 2.6-fold increased risk of death. Hyperinsulinemia led to a 3.7-fold increased risk of death (p <.05); concordantly, the risk of death decreased by 7%, per unit increase in insulin sensitivity (M). There was significant organ pathology in the AL at death. The age at median survival in the AL was approximately 25 years compared with 32 years in the DR. The oldest monkey was a diabetic female (AL) that lived to be 40 years of age. These results suggest that dietary restriction leads to an increased average age of death in primates, associated with the prevention of hyperinsulinemia and the mitigation of age-related disease.
Edited by Matt, 20 April 2008 - 03:57 PM.
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