[Mechanism of cartilage matrix remodeling by Wnt].
Wnt proteins play central roles in a variety of developmental processes and regulate cell differentiation, cell fate and cell proliferation. It has been also demonstrated that Wnt proteins profoundly participate in cartilage development. Interestingly, activation of Wnt/beta-catenin signaling in chondrocytes induces a profile of matrix degradation enzymes quite similar to that of cartilage matrix degradation such as osteoarthritis and rheumatoid arthritis. In this review we discuss the involvement of Wnt/beta-catenin signaling in pathological cartilage matrix degradation.
Would be a good idea to read the entire paper. The part in bold seems to be an observation, not a conclusion.
This study says that preventing the inhibition of Wnt helps repair bone erosion in joints. So using Lithium in therapeutic doses might be a good idea. Some caution is warranted though. Wnt beta catenin is activated in cancers. This is not worrisome if you don't already have cancer. The problem is, most popular supplements (curcumin, resveratrol, quercetin) and have anti-inflammatory properties, are also anti-cancer by inhibiting the beta catenin pathway. So they may retard healing in your case and mine.
Edited by Lufega, 01 September 2011 - 10:02 PM.