This recent article piqued my interest:
Hydrogen Sulfide: The Next Anti-Aging Agent?
The evidence is mounting, they note, that hydrogen sulfide slows aging by inhibiting free-radical reactions, by activating SIRT1, an enzyme believed to be a regulator of lifespan, and probably through its interactions with a gene, klotho, which appears to have its own market basket of anti-aging activity.
This got me back to recalling prior threads, conversations and topical discussion of H2S
Could Hydrogen Sulfide Hold The Key To A Long Life?
researchers found, to their surprise, that nematodes that were raised in a carefully controlled atmosphere with low concentrations of H2S (50 parts per million in room air) did not hibernate. Instead, their metabolism and reproductive activity remained normal, their life span increased and they became more tolerant to heat than untreated worms.
The H2S-exposed worms lived eight times longer than untreated worms...
Roth hypothesizes that H2S, a chemical normally produced in humans and animals, may help regulate body temperature and metabolic activity. Hydrogen sulfide is similar to oxygen at the molecular level because it binds at many of the same proteins. As a result, H2S competes for and interferes with the body's ability to use oxygen for energy production -- a process within the cell's power-generating machinery called oxidative phosphorylation.
The inhibition of this function, in turn, is what Roth and colleagues believe causes organisms such as mice to shut down metabolically and enter a hibernation-like state pending re-exposure to normal room air, after which they quickly regain normal function and metabolic activity with no long-term negative effects.
We know that garlic upregulates Hydrogen Sulfide production. Garlic is known to be heart healthy and act like an ACE-inhibitor.
1. Does anyone have any thoughts on the above? Should we just chalk it up to a SIRT1 activator and examine other SIRT1 activating compounds just as readily as H2S?
2. Various garlic extracts and supplements exist. Some do not contain Allicin (see chart toward bottom containing principal organosulfur compounds: http://lpi.oregonsta...emicals/garlic/). Which garlic supplement should we target?
3. Should we instead be targeting N-Acetylecysteine (NAC) and/or other compounds that stimulate H2S instead? (at least it doesn't smell like garlic...)
Edited by prophets, 31 January 2013 - 08:01 AM.