9 replies to this topic

[dislocation]

i tried mirapexin and it helped tremendiously for RLS but im confused of this mechanism. originally when i did it i thought dopamine agonists are supposed to give you stimulation, euphoria, but instead i got this extreme sedation with mirapexin. can someone explain whats the deal with dopamine agonism and sedation ? i thought antipsychotics which are dopamine antagonists are sedatives ??
its confusing to me how this works....

[NeuroNootropic]

Mirapex can cause sedation due to two things. First, it activates the dopamine autoreceptor leading to a decrease in dopamine release. The dopamine autoreceptor inhibits dopamine release when it is activated. It's most likely a feedback mechanism to ensure that dopamine isn't being flooded in the brain when at rest (i.e. no drugs, no activities that release dopamine, etc.). After the first 2 weeks taking pramipexole, the dopamine autoreceptors will downregulate though.

The second reason mirapex can cause sedation is because it decreases tyrosine hydroxylase expression, the enzyme that produces dopamine. Norepinephrine is a potent wakefulness-promoter, and is produced from dopamine. Decreased dopamine levels can therefore decrease norepinephrine levels.

Also, I think euphoria is a result of dopamine D1 agonism, and as far as I'm concerned, mirapex does not possess any significant affinity for the D1 receptors.

[arcticjoe]

I seriously advise against using this med, I know several people who have been very seriously (and permanently) screwed up by using prami. Lifelong DAWS which is near impossible to treat is not fun at all.

[golden1]

deprenyl makes me sedated too(unless I have coffee or something that probably releases norepinephrine downstream like exercise). dopamine isn't really stimulating, thats norepinephrine's job

[dislocation]

I seriously advise against using this med, I know several people who have been very seriously (and permanently) screwed up by using prami. Lifelong DAWS which is near impossible to treat is not fun at all.

what is DAWS ?? wtf never heard of this before and i read tons of info on mirapex before i ordered it. is this only a problem if you use it long term or few times is enough ??

deprenyl makes me sedated too(unless I have coffee or something that probably releases norepinephrine downstream like exercise). dopamine isn't really stimulating, thats norepinephrine's job

i really thought dopamine had euphoric, stimulant effect especially in inhibition, agonism but as that person said its only on D1 ? but i dont think any drug is out there that selectively affects only a single dopamine receptor. they all have affinity to the wide varierty of them which makes me sad now

[arcticjoe]

daws = dopamine agonist withdrawal syndrome, a member on another board got seriously messed up by pramipexole - there are several threads about it there, first one i could find: http://www.mindandmu...drawal-syndrome. I've heard about it happening to someone else as well - serious life changing effects, guy lost his job, relationships, etc.

not sure about how much needs to be taken to induce permanent changes to your dopamine system, but I think the first guy was only using it for several months... dont know about dosages, but i really would not touch prami even if you paid me.

Edited by arcticjoe, 11 May 2013 - 07:35 AM.

[medievil]

DAWS only lasts 2 weeks, that guy triggered an underlying issue like i did with a test cycle.

Prami is highly neuroprotective medication effective for alot of things.

Edited by medievil, 11 May 2013 - 05:01 PM.

[arcticjoe]

maybe so, but it looks like he is still unable to stop taking prami without suffering severe side effects.

[medievil]

That is because it works for shizo negatives, he also takes stuff for he's psychosis.

[dislocation]

yikes. not first thread i have seen related to withdrawl problems. it just works so damn well for RLS and also i found it puts me off nicotine. i tried to get high on nicotine while on mirapex, i couldnt stand it. was super dull and annoying. it seems to halt any addictions whatsoever. it has some good use ill say. do you think there is somethng safer to replace it with that works in similar manner on those same D receptors ?