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Methods to decrease serotonin neurotransmission?

5-ht catecholamines dopamine neurotransmitter cns reuptake ssris neurons

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#1 Guest_Funiture2_*

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Posted 19 June 2023 - 08:04 AM


There are several ways to reduce serotonin neurotransmission in the brain:

 

Pharmacological targets:

  • Antagonize 5-HT receptors (5-HT1b, 5-HT2a, 5-HT2c, 5-HT3, etc) directly
  • Agonize 5-HT1a autoreceptors (which inhibit neurotransmission at other serotonin receptors)
  • Increase SERT (serotonin transporter) activity
  • Increase MAO-A activity
  • Lower the activity of the two main serotonin synthesis enzymes, tryptophan hydroxylase & aromatic L-amino acid decarboxylase, (However, I'm not sure if there are drugs that actually target this)

Non-pharmacological:

  • Follow a low-tryptophan diet

Are there any other mechanisms I'm missing here that would lead to lower serotonin neurotransmission?

 

Thank you,

 







Also tagged with one or more of these keywords: 5-ht, catecholamines, dopamine, neurotransmitter, cns, reuptake, ssris, neurons

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