7 replies to this topic

[InquilineKea]

Just curious, as they basically do the opposite thing that sirtuins do.

[Bonee]

There are many classes of HDAC enzymes, and they are mostly associated with alternate cellular pathways.

I don't think most compounds that we categorize now as HDAC inhibitors would inhibit sirtuin.

http://en.wikipedia.org/wiki/HDAC

[galtsgulch]

Valproic acid is a histone deacetylase inhibitor which has various neurological effects and is used to treat depression, bipolar disorder, migraines, and epilepsy. It has also been found to extend the lifespan of C. elegans. See attached paper.

Attached Files

•  Valproic acid extends Caenorhabditis elegans lifespan (2008).pdf   261.05KB   5 downloads

[▲420MD]

Valproic acid is a histone deacetylase inhibitor which has various neurological effects and is used to treat depression, bipolar disorder, migraines, and epilepsy. It has also been found to extend the lifespan of C. elegans. See attached paper.

I take Valproic everyday, twice a day - is it actually going to increase lifespan in higher biologicals like mammals?

[niner]

I take Valproic everyday, twice a day - is it actually going to increase lifespan in higher biologicals like mammals?

Most things that increase lifespan in yeast, flies, and worms don't work in humans.

[▲420MD]

I take Valproic everyday, twice a day - is it actually going to increase lifespan in higher biologicals like mammals?

Most things that increase lifespan in yeast, flies, and worms don't work in humans.

I figured, do you think it could increase the aging rate? I don't know anyone who really likes Valproic Acid, but it has some interesting features.

[niner]

I take Valproic everyday, twice a day - is it actually going to increase lifespan in higher biologicals like mammals?

Most things that increase lifespan in yeast, flies, and worms don't work in humans.

I figured, do you think it could increase the aging rate? I don't know anyone who really likes Valproic Acid, but it has some interesting features.

I don't know; probably not. There's a lot involved in aging, mostly various forms of damage accumulation that accrue at their own rates. I wouldn't expect valproate to have a big effect there. On the other hand, it's a somewhat messy drug with a lot of side effects. Some of those are potentially pretty harmful, albeit rare. (and some not so rare) I seem to recall that it causes memory and cognitive problems in some people. It's pretty widely used though- I guess it has its place.

[Eruditus]

Is it possible to experience a more vivid eye colour from sodium butyrate increased production due to a high fibre diet? I was curious because a lot of people have told me my eyes have gone from being greyish blue to stark blue, much nicer looking tbh.