Well, I may as well add my recent weird experience here I keep a log book to note any changes in supplements and experiences so I can go back and see what happened when.
> Start Jul - started Niagen (Thorne Research) using two 60 cap bottles one 125mg, other 250mg. Varied the dose between 250mg and 500mg per day. All was well.
> Start Aug - switched to LCR Niagen in August (250mg). Dose at 250mg per day.
> Mid August - starting having left sole of foot pain. I do have some soreness always on this foot's big toe, BUT! This was way weird in that it showed up only when I was using the clutch in my car and it was excruciating pushing down on it. Now I've had the car since 2003, and we are as one. So I know that this pain was bizarre and unheard of before.
> End Aug - All of a sudden I had this strange and omnipresent "tight spot" in my right chest. It was like someone stuck a pin there and everything there was being held in place. It wasn't a sharp pain, or throbbing, just this weird tightness/little pain that scared the @#$% out of me! Heart attack? Cancer? Infection? This was totally out of context, esp. how it just began one day from nothing.
> Sept 3 - I stopped all supplements and, similar to Nate-2004, I take a bunch, probably too many. Still, although I had added several (including Niagen) recently this summer, I have taken many others for years. But the chest pain scared me enough to stop everything.
> Sept 21 - chest, foot pain much reduced, start taking ONLY Niagen, trans-pterostilbene, D-Aspartic Acid.
> Sept 24 - chest pain back
> Sept 27 - stop everything
> Oct 3 - chest tightness gone, foot pain gone. Start some supplements - the basics, Vit C, Carnatine, R-Lipoic Acid, Curcumin, mini-Multi, d-Lemonine, Gingo, quercetin
> Oct 5 - all is well as of today
Of course, as I take other things, so I can't blame this on just the Niagen, but there is the fact that after stopping and then starting it again the weirdness went away, then returned. It could also be the d-aspartic acid or trans-pterostilbene. Or it could be just something to do with LCR's Niagen specifically, maybe a bad batch?? Anyway, I'm going with my 'regular' supps for a while and adding others back in until (and if) that bad feeling returns.
Right now, I'm feeling as I'll add everything ELSE back in over time, then last thing - add LCR Niagen back.
Once this all began, this thread caught my eye, and although peoples experience was not identical to mine, the foot pain was too similar. Anyway, we'll see what happens as I add things back in, and finally - LCR Niagen.
Thought it was about time for an update (re: ^ the above) with NR, perhaps others will glean something from the postmortem.
It's been a month or two since I had foot and chest soreness & stopped all my supplements. I like to get back to "clean' when problems arise.
Where I left off on Oct 3th much of the soreness was gone and I restarted some sups. From my diary going forward:
> Oct 3 - restart the basics, Vit C, Carnatine, R-Lipoic Acid, Curcumin, Multi, d-Lemonine, Gingo, EMIQ (quercetin)
> Oct 9 - restart Gliadin Complex (GliSODin 300mg, Catalase 100mg, L-Glutathione 50mg), L-Carnosine 500mg
> Oct 12 - RESTART NR 80mg (LCR) AM
> Oct 14 - restart fish oil 1500mg, NEW Resveratrol Complex 1200mg AM/PM, PQQ 20mg
> Oct 20 - restart Phosphatidylserine 300mg AM
> Oct 20 - NEW Apigenin 50mg AM
> Oct 25 - UP NR to 125mg AM/PM (LCR)
> Oct 31 - UP NR to 250mg AM (LCR)/ 125mg PM (Nectar7)
> Nov 5 - NEW Magnesium Lysinate Glycinate 250mg /Malic Acid 830mg
> Nov 7 - restart D-Aspartic Acid 3.5g AM, MSM 1g, Ubiquinol 100mg AM
I've pretty much come full circle w/supplements, but the problems haven't returned. I've added a couple, but I've backed off using protein powders/bars in a big way. I was taking goat, plant, and egg proteins daily vs. now infrequently. That may be something, I'm not sure.
Supplements I noticed that had a major "feeling good/better' effect are the Resveratrol Complex, twice daily, and D-Aspartic Acid (AM). The Resveratrol Complex reduced residual joint soreness significantly, with foot soreness decreased or gone away in a major way. It may be old school, but I swear it's doing something good.
Resveratrol ingredients per dose:
600 mg 50% trans-Resveratrol
150 mg Pomegranate extract 40% Ellagic Acid
150 mg Green Tea 98% polyphenols
100 mg Quercetin (in addition to EMIQ)
100 mg Grape Seed Extract 95% polyphenols
100 mg 4:1 Extract Enzymes
Then restarting the D-Aspartic Acid really seemed to give a powerful energy feeling for working out at the gym. I love that stuff, it makes a big difference for me. So, in the end, perhaps NR wasn't the issue, perhaps the chest strain could have been just that - a strain from exercise at the gym. Perhaps it was taking a sups break. I do have notes starting on OCT 6th that I was feeling really great and full of renewed energy, which has continued. The weights I use at the gym are going up again - that's encouraging, and so far no problems or even muscle soreness.Typically I'm four days/wk at the gym 1-1.5 hrs. I truly believe I need lots of strenuous exercise/energy expenditure to utilize all these supplements.
On the downside, I do notice some early AM "wake up and can't sleep issues", maybe that's to be expected on a 250mg AM / 125 mg PM NR dose, but it's not such a big thing on the scale of 1-10, considering how good I feel otherwise. Also, a tendency I'd had to take afternoon naps before starting NR (retirement is great) is gone. It seems I've energy to spare all day long, which I like. I do tend to crash about 9:30-10PM though. One last negative (sort of) is although I'm a craft beer lover, I'm finding I just don't care so much about alcohol currently. Strange. When I do imbibe, it's hard to get a whole pint down! What's up with that!
I'm going to stick with this for a while, hopefully with continued great results. The only other thing I'll be adding is "Robuvit French Oak Wood Extract" to produce more urolithins from the Robuvit (if I have the right gut bacteria) and so greatly increase my mitophagy. Seems only sensible as I theoretically produce so many new and rejuvenated mitochondria using NR et al, might as well get rid of the old, worn out stuff clogging up the cells.