2 replies to this topic

[Biologist]

Retinyl Palmitate "poor man's accutane" has and is being used successfully to systemically treat acne at doses comparable to Isotretinoin aka Accutane (40 mg/day accuate would roughly equate to 130000 IU Vitamin A if equivalent).

 

Now, the UL of Vitamin A is only 10000 IU / day - all about that here: the lowest dosage where vitamin A induced liver damage was suspected divided by 5. The case in question was a woman having consumed 25000 IU/day for about 6 years. Comparing hers to other cases in the above paper, it seems to be the TOTAL amount consumed over time that matters.Her dose would then be roughly equivalent to consuming 150000 IU/day over 1 year.

 

So, any way to make vitamin A supplementation safer? Some ideas:

1. Do 100 000 IU for 1 month and then go down to 10000 IU and hope acne stays away?
2. Any liver support supplements that could mitigate vitamin A toxicity?
3. Is Isotretinoin really much safer? If it is, low dose Isotretinoin > low dose Retinyl Palmitate.
4. Can Vitamin A be combo'd with other supplements, e.g. Vitamin B5 to maintain efficacy and reduce risk?

Cheers!

 

 

 

 

 

Edited by johanknu, 19 April 2014 - 06:39 AM.

[mikey]

First, is the acne caused by a high-sugar diet, poor-quality fatty acid intake, like fried foods or some other dietary problem?

 

Eating sugars/sweets/grains - anything that increases blood sugar increases the potential for acne outbreaks.

 

Acne infection should be easily stopped by a strong immune system accompanied by a clean, healthy diet that doesn't feed bacteria.

 

 

 

[elemerendero1]

Damn , I had made a mega -post to explain why YOU DO NOT HAVE TO USE THOSE SUBSTANCES, but it erased everything . Damn !

In short :

- Isotretinoin is bad for the liver
- I think that the substance you mentioned , is similar ( both derived from vitamin A), then also it is to be avoided
- These substances cause serious problems , including non- passengers and distance of years , not just physical ( tantissimi. .. in addition to the liver and teratogenicity I can think of an ulcer , but there are many many many others ), but mainly mental , anxiety , depression, suicide
- There is the use of vitamin B5 in mega doses (up to 20 grams) and although I do not like mega- doses of retinoic prefer to derivatives and similar
- To avoid using mega- doses of vitamin B5 , my advice is :

antibiotics ( only initially for a limited period from 3 to 6 months) + + isotretinoin topical vitamin B5 ( precursor of coenzyme - A) + L-lysine ( precursor of coenzyme - A) + Acetyl- Carnitine ( same function as the coenzyme -A . fat metabolism .. ) + Inositol ( as a coenzyme -A) + PQQ (antioxidant) + N - acetylcysteine ​​( an antioxidant and improves liver function ) .

In addition, I hypothesize it might be useful to try the intermittent fasting as a diet , because acne is also influenced by ' IGF-I, and this diet greatly decreases its concentration .