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Pin Cone/pollen: inhibit deletion mutation of mtDNA. Anti: Tumor, viral, arthritis, aging

pine cone pine pollen anti aging anti tumor anti arthritus

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#1 Logic

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Posted 17 August 2014 - 08:17 PM

Pine Bark extract is well known here, but there does not seem to be anything on Pine Cone Extracts and Pine Pollen.

It was the fact that many statues/ sculptures artefacts etc exist of pine cones that got me wondering about medicinal properties in the first place and they certainly seem worthy of further research IMHO.

Effect of pine pollen on kidney mitochondria DNA deletion mutation in senile mice
Pine pollen can inhibit deletion mutation of mtDNA in senile mice, suggesting that pine pollen can reduce oxidative damage of mtDNA and protect mtDNA..."


Effect of pine pollen extract on experimental chronic arthritis
"...The arthritis score and paw edema were markedly suppressed in the groups treated with PE. Moreover, administration of PE (100 mg/kg) for 49 days reduced the serum levels of rheumatoid factor, anti-type II collagen antibody, TNF-alpha, IL-1beta, IL-6, protein carbonyl, advanced glycation endproducts, malondialdehyde and LDL-cholesterol compared with that of CIA mice. These results suggest that the pine pollen might be beneficial in the treatment of chronic inflammatory disorders..."

Antiaging effect of pine pollen in human diploid fibroblasts and in a mouse model induced by D-galactose
"...Pine pollen (1 mg/mL and 2 mg/mL) is proved to delay the replicative senescence of 2BS cells as evidenced by enhanced cell proliferation, decreased SA-β-Gal activity, and reversed expression of senescence-associated molecular markers, such as p53, p21(Waf1), p16(INK4a), PTEN, and p27(Kip1) in late PD cells. Besides, pine pollen reversed D-galactose-induced aging effects in neural activity and inflammatory cytokine levels, as indicated by improved memory latency time and reduced error rate in step-down test and decreased concentrations of IL-6 and TNF-α in model mice. Similar to the role of AGEs (advanced glycation endproducts) formation inhibitor aminoguanidine (AG), pine pollen inhibited D-galactose-induced increment of AGEs levels thus reversed the aging phenotypes in model mice. Furthermore, the declined antioxidant activity was obviously reversed upon pine pollen treatment, which may account for its inhibitory effect on nonenzymatic glycation (NEG) in vivo. Our finding presents pine pollen as an attractive agent with potential to retard aging and attenuate age-related diseases in humans..."

Antitumor, antiviral and immunopotentiating activities of pine cone extracts: potential medicinal efficacy of natural and synthetic lignin-related materials (review).


Edited by Logic, 17 August 2014 - 08:25 PM.

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#2 ClarkSims

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Posted 09 September 2014 - 10:16 PM

Perchance do you know of any human studies?



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#3 Logic

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Posted 09 September 2014 - 11:51 PM

Perchance do you know of any human studies?

I don't Clark, else I would have posted them here, but it does seem to have a long history of use in eastern medicine.

Check the references here:
(Interesting study too! :) )

Also tagged with one or more of these keywords: pine cone, pine pollen, anti aging, anti tumor, anti arthritus

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