Fermented MSG converted into GABA enhanced short term mermory recovery in mice administered scopolamine:
https://drive.google...it?usp=sharing
γ-Aminobutyric acid (GABA) can be produced from 12% (w/v) monosodium glutamate (MSG) by the lactic acid bacteria Lactobacillus sakei B2-16, which was isolated from kimchi. This production of GABA has the highest conversion yield from MSG. In passive avoidance tests, GABA improved the long-term but not short-term memory recovery of mice administered scopolamine; 46.69 mg/mL GABA significantly improved the memory from 132 sec to 48 sec. The addition of 667 mg/mL of fermentation broth containing 46.69 mg/mL of GABA enhanced memory recovery up to 85% compared to the control group, but lower doses only enhanced memory 20%. These results imply that a high-dose intake may be necessary for the desired efficacy of GABA. GABA-mediated neurological effects were also confirmed by the growth of PC12 nerve cells, which demonstrated an increase in both growth and neurite differentiation with a ∼45% increase in the number of neurites per cell and a 65% increase in neurite outgrowth compared to the control group (no treatment). Most of these results were of greater magnitude than those reported for other plant resources. This is the first report of GABA obtained from MSG fermentation enhancing recognition functions using bothin vivo and in vitro experiments, even though there were several reports on producing mass amounts of GABA from MSG fermentation. The findings could expand the use of GABA for many purposes as a natural and functional substance obtained from fermentation processes.
Can any one valid the claim Pharagaba crosses the BBB?
http://www.natural-pharmagaba.com/
http://www.longecity.org/forum/topic/21599-pharmagaba-feedback/
Alternatively
A "new"form of GABA, produced from Lactobacillus hilgardii, is being marketed as the only form of GABA that crosses the blood/brain barrier. Having studied the molecule for years, I submit that GABA is not a typical left- right rotatory molecule, but rather is part of a macromolecular complex whose biochemical functions are independent of rotation. Because this new form of GABA is no different from pharmaceutical grade GABA in its molecular structure and mechanism of action, it is illogical to contend that it crosses the blood/brain barrier. Additionally, growing GABA from a culture is dangerous because of the potential for bacterial contamination.
http://connection.eb...experience-gaba
