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GABAergic Kindling and Withdrawal

kindling gaba gabaergic benzos alcohol ghb etizolam withdrawal

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#1 BioInfinite

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Posted 25 February 2023 - 07:01 AM

Has anyone experienced this? If so what was your experience? Did anything help?


Personally I used to do a lot of sedatives over several years including Alcohol, GHB, benzos, z-drugs, Gabapentin, Baclofen, etc as self medication for anxiety and chronic insomnia. I thought I'd be fine as long as I don't build tolerance, how naive I was. Instead I seemed to develop reverse-tolerance.


Eventually I also got serotonin toxicity from Etizolam combined with other serotonergic drugs such as psychedelics which seemed to coincide with the beginning of my kindled state. Anything that was GABAergic in nature triggered what felt like hell, an intense mental pain. I guess that was instant withdrawal. 


I was still able to drink alcohol after a few months, but each time the buffer grew smaller and smaller until no amount of abstinence reversed the precipitation of that state, so naturally I quit that forever. 


Then over the next decade I continued getting more and more sensitive to foods that have a GABAergic action, no matter how small. For example- balsamic/cider/wine vinegars (GHB content), lemongrass in Thai curry, other spices, de-alchoholised wine/beer, anything brewed, and so on. All these would trigger instant withdrawal.


Interestingly, I know other herbs and foods that have similar GABAergic actions which did not seem to have any negative effect (some until later, some I have been very careful with - I rarely ingest - such as herbs like oregano and basil that contain rosmarinic acid and to date have not reacted to). It seems the triggers are repeated exposure to specific agonists rather than cumulative agonism.


Does anyone know anything that could help or reverse it?


I was looking into BPC-157, though its action is a bit ambiguous. 


Any suggestions to help me or others with this issue would be greatly appreciated.


Thank you



#2 YoungSchizo

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Posted 10 March 2023 - 02:49 PM

I think you should post this in brain health and maybe the supplement section. I guess there they might see your post and give you proper advise. This doesn't seem like a mental health problem.


I hope it never happens to me what you have, I love GABAergics as they really help with mental health (benzo's). I wish there was more focus on GABAergic drugs for mental health.

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Also tagged with one or more of these keywords: kindling, gaba, gabaergic, benzos, alcohol, ghb, etizolam, withdrawal

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