68 replies to this topic

[rikelme]

 
Do you have the reference to the vitamin E claim? Because I think that VECAR (a novel heterodimer of α-tocopherol (vitamin E) and carnosine) is not the same as taking Carnosine and vitamin E separately and, in fact, what I've found is 
 
Dietary vitamin E, but not carnosine, increased levels of vitamin E  
 
Muscle vitamin E concentrations were not significantly affected by dietary carnosine.
 
Carnosine supplementation significantly increased E levels in liver and heart, but not in skeletal muscle, serum, or erythrocytes.

 

 

 

but I'm not able to find any research about Vitamin E increasing carnosine efficacy. 

 

 

@William

 

I don't think it is easy (or even possible) to find original research that made them buffer α-tocopherol with l-carnosine (I understand it's not just a mixture of the two, but special (which one?!) buffering technique).

 

However, a quick search on pubmed does give some confirming research (seems to come from the same group of Turkish scientists):

 

Effect of carnosine alone or combined with α-tocopherol on hepatic steatosis and oxidative stress in fructose-induced insulin-resistant rats. [1]

Protective effects of carnosine alone and together with alpha-tocopherol on lipopolysaccharide (LPS) plus ethanol-induced liver injury. [2]

 

[1] https://www.ncbi.nlm...pubmed/24464863

[2] https://www.ncbi.nlm...pubmed/26773358

 

(full papers available on sci-hub [dot] cc)

 

Cheers!

[jack black]

 

The results are in re: wrinkles. I have pre and post (3 weeks of carnosine) pictures of my face and there are more wrinkles after! So much for that.

 

I can't think of a biochemical reason why carnosine would be expected to reduce wrinkles in 3 weeks.  At most, it might slow the accumulation of wrinkles slightly by slowing glycation.  You'll still have to wear sunscreen though, as carnosine isn't going to stop the UV damage that is far and away the biggest cause of wrinkles.  Finally, if you take pictures every month for a year, you will probably find the appearance of your wrinkles varies over time depending on your weight, hydration status, moisturizer use and the current relative humidity.

 

 

my bad, i was naive to believe in miracles.

[Tom Andre F. (ex shinobi)]

 

The results are in re: wrinkles. I have pre and post (3 weeks of carnosine) pictures of my face and there are more wrinkles after! So much for that.

 

I can't think of a biochemical reason why carnosine would be expected to reduce wrinkles in 3 weeks.  At most, it might slow the accumulation of wrinkles slightly by slowing glycation.  You'll still have to wear sunscreen though, as carnosine isn't going to stop the UV damage that is far and away the biggest cause of wrinkles.  Finally, if you take pictures every month for a year, you will probably find the appearance of your wrinkles varies over time depending on your weight, hydration status, moisturizer use and the current relative humidity.

 

 

I dont know if its can be the reason but what brand carnosine do you buy ? Before to choose a supplier for our pure carnosine (Dynveo.com) we found out carnosine doesnt equal another carnosine... why ? Because most we tested was full of harsh chemical packaged along, even for those pharma grade.. it depends the root of synthesis used, cheap one or more elaborated like the one we use.. Its like for fillers, we pay 2 times more expensive but at the end we hve zero % fillers.. Anyway, just saying, I dont want to advertise here, but some solvant used could be toxic and trap H2O that much

 

For skin still the best for glycation was rosmarinic acid
 

[Felix375]

Hey guys,

 

About 14 years ago I was on 1g of carnosine a day, 500mg morning and night.

 

I was getting my biochemistry degree at the time. Serendipity struck. I walked into biochem lab and the professor says we're going to run HbA1c test on you. You will do the work and write it up.

 

I only have data for one person but I had a control. My brother and I were roommates at the time and we ate the exact same thing. I had been on carnosine for a few months. He wasn't.

 

I did the lab work using the exact same equipment on both samples.

 

My brother's results came out to 5.2% which is right in the normal range. Mine came out as 2.3%. My professor thought something was wrong. I told him I was on carnosine and it prevented glycation.

 

The rest of the class came out in the normal range. I was the only one that had a low HbA1c.

 

I was very happy at the time. I found out that carnosine works. I was about 35 years old.

 

Felix

[jack black]

Hey guys,

About 14 years ago I was on 1g of carnosine a day, 500mg morning and night.

I was getting my biochemistry degree at the time. Serendipity struck. I walked into biochem lab and the professor says we're going to run HbA1c test on you. You will do the work and write it up.

I only have data for one person but I had a control. My brother and I were roommates at the time and we ate the exact same thing. I had been on carnosine for a few months. He wasn't.

I did the lab work using the exact same equipment on both samples.

My brother's results came out to 5.2% which is right in the normal range. Mine came out as 2.3%. My professor thought something was wrong. I told him I was on carnosine and it prevented glycation.

The rest of the class came out in the normal range. I was the only one that had a low HbA1c.

I was very happy at the time. I found out that carnosine works. I was about 35 years old.

Felix

This is a complete BS. You can't do an experiment with one subject and one measurement even when you have a control.

Furthermore, my A1c is monitored every 6 months (prediabetes) and there is no difference whatsoever between before carnosine and after.

[aribadabar]

 

Furthermore, my A1c is monitored every 6 months (prediabetes) and there is no difference whatsoever between before carnosine and after.

 

 

What was your dosing regimen and for how long have you taken carnosine before the test?

[jack black]

 

 

Furthermore, my A1c is monitored every 6 months (prediabetes) and there is no difference whatsoever between before carnosine and after.

 

 

What was your dosing regimen and for how long have you taken carnosine before the test?

 

 

I took it for about 5 months before the recent test. initially 500mg/day, then i increased to 2x500mg for a couple of months, and decreased back to 500mg about a month ago, as i'm running low and need to order more.

[Skyguy2005]

What are the effects of carnosine on autophagy?

[William Sterog]

What are the effects of carnosine on autophagy?

However, treatment with carnosine significantly attenuated autophagic signaling in the ischemic brain, with improvement of brain mitochondrial function and mitophagy signaling. The protective effect of carnosine against autophagy was also confirmed in primary cortical neurons.

https://www.ncbi.nlm...pubmed/24938837