I believe my anxiety and depression are caused from low dopamine do to experiences I’ve had with two dopaminergic drugs (I had positive effects from wellbutrin and mucuna pruriens a Chinese bean with L-dopa in it) as I think a lot of other cases are too and that SSRI’s are overly prescribed medications that a lot of people don’t respond to. Dopamine increase motivation and reward and norepinephrine the byproduct of dopamine increases focus and concentration which all depressed people lack. There are virtually no DRI’s other than research chemicals which I don’t understand their rarity(haven’t researched that a lot). I’m finding it extremely hard to find a safe longterm antidepressant that boosts dopamine, especially ones that are on the market.
( something like this)
Does anyone know what I could try if I was trying to boost my dopamine? Or does anyone know of any NDRI’s that have a stronger affinity for dopamine that would be effective and with a good half life(not Ritalin and the such either) or lastly, just normal NDRI’s(don’t want these because they have a tendency to increase anxiety long-term, I’ve tried Wellbutrin it didn’t work)? I’d prefer ones that are on the market but if someone can find ones off the market that are safe that’d be useful too.Is Amineptine(tricyclic, possible liver damage) a good NDRI? It prefers dopamine over norepinephrine. It has a short half life which could make it more addictive and less suitable for a longterm antidepressant. It’s hard to obtain and the source I have I wouldn’t know the purity of it as I can’t test it although it looks promising as an antidepressant.
I’m currently set on serzone ( an SNDRI and serotonin antagonist, possible liver damage 1 in 250,000 according to wiki don’t if that is correct), and the MAOI’s Parnate (works more on MAOI B then A), Nardil(works equally on MAOI A and B), selegiline(MAOI B). Also, dopamine agonists although I don’t know if they would be effective antidepressants. Overall, MAOI’s have the most drugs that boost dopamine, that are FDA prescribed, equally among the other neurotransmitters instead of norepinephrine more and such. The fact that even if they are MAOI type A they still boost dopamine equally, is how I take it, to the other monoamines (tyramine, serotonin, norepinephrine). There just aren’t a lot of NDRI’s, DRI’s, and triple reuptake inhibitors.
I just started modafinil as it's supposed to be a weak dopamine reuptake inhibitor but don't seem to be getting any results after 3 tabs(2 last night and one this morning).
List of MAOI’s: http://mentalhealthd...ase-inhibitors/
List of some NDRI’s: http://mentalhealthd...ors-ndris-list/
-Focalin-This drug consists of the D-stereoisomer of methylphenidate (Ritalin) and was developed by the company Novartis as an ADHD medication. It functions by preventing reuptake of norepinephrine and dopamine and elicits a stimulant effect on the CNS. It is known to be well-tolerated and effective when used for attentional deficits and has also been considered as an adjunct strategy for treating certain cases of depression.
-Ethylphenidate –not sure if this is safe, read a lot about how it disagrees with the body, looking for a safe longterm antidepressant
This is a drug that functions as a psychostimulant and is considered relatively similar to methylphenidate (Ritalin) in its effects. It functions as a norepinephrine-dopamine reuptake inhibitor, with a stronger affinity for dopamine.
Nomifensine looks safe except for the risk of haemolytic anaemia to which the FDA withdrew approval for nomifensine on March 20, 1992 although it doesn’t prefer dopamine over norepinephrine
List of NDRIs according to wiki
The section only lists compounds that are selective for NET and DAT relative to the serotonin transporter (SERT). For a list of compounds that inhibit reuptake at all three transporters, see serotonin-norepinephrine-dopamine reuptake inhibitor.
Many NDRIs exist, including the following:
· Amineptine (Survector, Maneon, Directim)
· Desoxypipradrol (2-DPMP)
· Dexmethylphenidate (Focalin)
· Difemetorex (Cleofil)
· Diphenylprolinol (D2PM)
· Fencamfamine (Glucoenergan, Reactivan)
· Fencamine (Altimina, Sicoclor)
· Lefetamine (Santenol)
· Methylenedioxypyrovalerone(MDPV)
· Methylphenidate (Ritalin, Concerta, Metadate, Methylin, Rubifen, Stimdate)
· Nomifensine (Merital)
· O-2172
· Pipradrol (Meretran)
· Prolintane (Promotil, Katovit)—experience- http://www.longecity...prolintane-hcl/
· Pyrovalerone (Centroton, Thymergix)
· Tametraline (CP-24,411)
· WY-46824