By the way, I don't believe that GABAa receptors can be "downregulated" and reverse the tolerance to it. I have been unable to treat my anxiety sustainably. The only medications that work are either GABAergic or "antiglutamatergic", to which I build tolerance fast, hence my nickname. However check out this thread on a new compound, which may be sustainable.
Read the comment made one comment below yourself.
Thanks for pointing this out to me. May I ask, how quickly did you notice results? Did you try and GABAergics before and develop tolerance to them? If so, which ones? Can you also shed light on which prohormones you're talking about, and where do you get prohormones/DHT?
I'm broadly aware that neurosteroids can have an anxiolytic effects through action at GABA-a receptors. I have tried taking pregnenalone with no effect. Curiously, there is a paper that specifically addresses the question of tolerance to neurosteroids -- specifically, allopregnanolone. It is quite conclusive that allopregnanolone causes tolerance to allopregnanolone itself and to other GABAergics.
Androsterone has GABAergic effects in of itself and also when it converts to dht.
Epiandrosterone supposedly does not have GABAergic effects in of itself and needs to convert to dht first.
A combo of andro and epiandro seems to induce a male teenie mentality in me, for whatever reason.
DHT cream (2.5%) itself is very effective and works every single day (for me), even after 3 months of using it daily.
It seems Ginkgo Biloba is also very effective and has a broad spectrum of effects, but it causes massive headaches in myself that last for more than 2 days, I'm talking caffeine-like headaches.
p5p (coenzyme B6) with l-glutamine converts partly to GABA but it seems to feel exactly like taking GABA itself - namely it's mildly effective and it actually feels like taking l-leucine in that it seems to be a "confidence" buster and energy depleter.
I haven't tried going with a higher than 30mg p5p dosage (500mg glutamine) but maybe I should just to test it.
I mixed 25mg of non-micronized DHEA (soure of estrogen) with my dht cream which induced a feeling of masculinity I don't think I've felt before. Like being 13 or 16 again.
Edited by RatherBeUnknown, 31 May 2016 - 12:54 PM.