5 replies to this topic

[brosci]

I found this supplement while looking for different brands of MCT oil (particularly C8 MCT oil) in glass bottles:

 

http://prototypenutr...m/ur-spray.html

 

It's a topical Arginine Ursolic Acetate which scoots around the low bioavailability of ursolic acid.  In reading online, I'm unable to determine if this is a safe supplement wrt cardiovascular / systemic health or something to be avoided.  I suppose it could also be snake oil.

 

Here's what I was able to dig up.

http://www.atheroscl...0935-X/fulltext

 

http://libgen.io/sci...9&downloadname=

 

Thoughts?

[niner]

Here's some newer papers on UA and atherosclerosis.  Just glancing at titles, it looks like the newer ones are pointing to it being safe-ish, but I've not read the papers. 

[RWhigham]

https://www.ncbi.nlm...les/PMC3379974/ "Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease"

 

Standardized Holy Basil extract contains 2% wt/wt of ursolic acid.  The extraction uses ethanol.

http://www.mdpi.com/...7/12/8/5319/pdf  (Water extraction, eg Tulsi tea, seems useless for ursolic acid.)

 

In this study, rosemary extracts had between 0% and 40% ursolic acid, depending on the rosemary collection area.

https://www.ncbi.nlm...les/PMC4264185/

 

You can buy rosemary extract standardized to 25% wt/wt of ursolic acid. Look under "ursolic acid supplements" The best deal I found on Amazon is 180 capsules at 75mg ea for $19.99. The recommended dose is 300 mg/day.

 

The magnitude of effects seems quite modest. Reviewers on Amazon mostly just noticed a little weight loss.  

Edited by RWhigham, 24 November 2016 - 11:02 PM.

[Kirito]

In mice: UA significantly increased SIRT1 (∼3.5±0.3 folds) and SIRT-6 (∼1.5±0.2 folds) proteins overexpression (P<0.001). In addition, our results showed that UA enhanced α-Klotho (∼3.3±0.3) and PGC-1β (∼2.6±0.2 folds) proteins levels (P<0. 01)

 

https://www.ncbi.nlm...pubmed/27470332

 

Another paper - a very recent one:

 

UA enhanced SIRT1 (~ 5 ± 0.2 folds) and SIRT6 (~ 8 ± 0.5 folds) proteins levels in hepatic, p&lt;0.001. In addition, the data showed that UA increased PGC-1β (~ 7 ± 0.4 folds) protein overexpression, p&lt;0.001. Moreover, we showed that UA up-regulated Klotho (~ 3.5 ± 0.2 folds) protein in order to improve hepatic performance

 

https://www.ncbi.nlm...pubmed/28558631

 

I'm looking into taking UA again, or I might just grow a bunch of rosemary.

[brosci]

In mice: UA significantly increased SIRT1 (∼3.5±0.3 folds) and SIRT-6 (∼1.5±0.2 folds) proteins overexpression (P<0.001). In addition, our results showed that UA enhanced α-Klotho (∼3.3±0.3) and PGC-1β (∼2.6±0.2 folds) proteins levels (P<0. 01)

 

https://www.ncbi.nlm...pubmed/27470332

 

Another paper - a very recent one:

 

UA enhanced SIRT1 (~ 5 ± 0.2 folds) and SIRT6 (~ 8 ± 0.5 folds) proteins levels in hepatic, p&lt;0.001. In addition, the data showed that UA increased PGC-1β (~ 7 ± 0.4 folds) protein overexpression, p&lt;0.001. Moreover, we showed that UA up-regulated Klotho (~ 3.5 ± 0.2 folds) protein in order to improve hepatic performance

 

https://www.ncbi.nlm...pubmed/28558631

 

I'm looking into taking UA again, or I might just grow a bunch of rosemary.

 

What are your thoughts on topical complexed UA?  From what I understand, it's not very bioavailable in humans.  Eg., http://prototypenutr...m/ur-spray.html

[Rocket]

https://www.ncbi.nlm...les/PMC3379974/ "Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease"

 

 

Too bad it doesn't work in humans. Lots of people on bodybuilding forums have tried it to no avail. It apparently only works in mice.

Edited by Rocket, 03 January 2018 - 09:55 PM.