3 replies to this topic

[Math Help]

I can't seem to find a definitive "yes they're inversely related" or "yes they're directly related", so I wanted to see if someone could shed some light on the relationship between the amount of ACh and NE in the brain. Thank you!

[Valor5]

I think the drug strattera raises both but some of the tricyclics shut down one if I remember correctly.

Edited by Valor5, 05 May 2017 - 11:23 AM.

[PeaceAndProsperity]

It seems it's more complex than the relationship between prolactin and dopamine where raising the one necessarily lowers the other to some extent (and in studies they use prolactin as an indicator of pharmacological effects on dopamine).

 

Serotonin and dopamine are supposedly inversely correlated or opposing but you can take a precursor to the one and it won't do much if anything against the other.

 

It does seem that there are SOME opposing effects of NE and acetylcholine.

[Mind_Paralysis]

It seems it's more complex than the relationship between prolactin and dopamine where raising the one necessarily lowers the other to some extent (and in studies they use prolactin as an indicator of pharmacological effects on dopamine).

 

Serotonin and dopamine are supposedly inversely correlated or opposing but you can take a precursor to the one and it won't do much if anything against the other.

 

It does seem that there are SOME opposing effects of NE and acetylcholine.

 

It could also be as simple as the fact that NE is synthesized from DA, and aCh does oppose DA - hence, there is less NE as well.

 

 

Norepinephrine, Epinephrine and Acetylcholine - Synthesis, Release and Metabolism

http://www.cvpharmac.../norepinephrine