Its indeed interresting but allways consider how to reverse something when it turns out to be problematic.
the body´s own mechanism is able to do so after a given time (months to Years) but, depending on the mechanism, not allways !
Like in the case of longterm alterations from cocaine.
Found this:
Human genome guided identification of memory-modulating drugs
Table 2
Antidepressants (e.g., mirtazapine) = HTR2A
....
Fasoracetam = GRM1, GRM5
Memantine = GRIN2A
Antipsychotics = CHRM2, CHRM3, CHRM5, GRIN2A, HRH1, HTR2A
http://www.pnas.org/.../E4369.full.pdf
e.g. GRM5 = Metabotropic glutamate receptor 5
I cant tell whether those are up or downregulated.
Neither respectively or e.g. completely upregulated.
-------------------------------------------------------
Edit: Altough its a bit of topic its still interresting:
- (postsynaptic?) 5-ht1a seems to inhibits ampa and nmda currents:
..5-HT1A receptors are also involved in the modulation of excitatory glutamatergic neurotransmission, since their activation suppresses AMPA-mediated signaling through the inhibition of CAMKII (Cai et al., 2002a) and reduces NMDA-mediated currents in PFC neurons (Zhong et al., 2008
Serotonin modulation of cortical neurons and networks
http://www.ncbi.nlm....les/PMC3630391/
But also protect against Glutamte toxicity
A Review of the Neuroprotective Propertiesof the 5-HT1AReceptor Agonist Repinotan HCl (BAY x 3702) in Ischemic Stroke
WAY 100635 blocked these effects, indicating that the neuroprotective properties of repinotan are mediated through the 5-HT1A receptor.
The proposed neuroprotective mechanisms of repinotan are thought to be the result of
neuronal hyperpolarization via the activation of G protein-coupled inwardly rectifying K+ channels upon binding to both pre- and post-synaptic 5-HT1A receptors. Hyperpolarization results in inhibition of neuron firing and reduction of glutamate release
http://onlinelibrary...5.tb00055.x/pdf
more infos on 5-ht1a:
http://www.pssdforum. co m
An interesting article
http://www.pssdforum...?f=5&t=13#p2138
http://www.pssdforum...&start=10#p2164
Edited by Flex, 12 April 2015 - 12:23 PM.