I have severe rheumatoid arthritis at a fairly young age. The prospectives are not good currently. My rheumatologist doesn't seem to be able to get it under control. Meanwhile I'm experiencing very evident muscle wasting in hands, feet, arms, legs, shoulders, neck, aka 'rheumatoid cachexia', next to swelling in lots of joints. I'm afraid my organs will be next in line to suffer the consequences. I already seem to have slight problems in my hearing as of the past few months.
I've tried to target the nrf2 pathway using sulforaphane in high amounts, but albeit pain seems better: results have been 'so so' thus far. Swelling in joints is still very much present, as is the muscle wasting. I have also added high doses of green tea with the same purpose.
I eat a vegan diet, no processed foods, all organic with lots of (green) veggies, some berries. There are not a lot of frills in my supplement list: I do take collagen type 2 UCII and Biocell type 2 collagen, as well as silica, boron, MK-7, strontium for the sake of my joints. As well as some probiotics given the established link with the microbiome.
I have tried curcumin to tone down inflammation, as well as CBD-oil. Not much effect from that either, and for several reasons I had to stop taking the curcumin.
It would absolutely be helpful to get some more suggestions of what I could do/try.
Thanks in advance!!