Hello, i have found a interesting 2016 study where a single gene has been knockdown rising the mean right answer of a problem solving test (puzzle box) from 20% to almost 50%.
i dont know what would correspond such improvement for human standard, but maybe 15-30 (1 to 2 standard deviation) iq point?
the same gene knockdown in another study enhanced memory (ltp).
enhanced problem solving + lower anxiety: https://sci-hub.tw/h...012496616040098
enhanced memory: https://www.cell.com...6273(03)00334-9
the gene is SLC8A2 encoding: Na+/Ca2+ exchanger (NCX2)
some study with a similar compound acting on the same "pump" lead to reduced risk of dementia: https://www.ncbi.nlm...les/PMC4923720/
fk506 inhibits other ncxs and does not cause reduction of the protein: https://books.google...06 NCX2&f=false
psc833 inhibits other protein causing damage
the problems are:
-inhibition nxc3 lead to memory impairment.
-nxc1,3 are present in other part of the body so inhibition could cause other problems
-inhibition of NCKX leads to memory impairment.
SOLUTION:
-find a selective inhibition of ncx2
-find a selective down regulator of its gene.
problems anyway:
im not sure if inhibition in a adult would have the same nice effects of knocking down the gene
Edited by Painkillerrr, 10 September 2018 - 10:45 AM.