Alibaba.com has rapamycin, $45/gram to $90/gram. I ordered some and it arrived. If you look online there is a a paper on making nanoparticles each of which simultaneously contain piperine, a GI tract absorption enhancer with rapamycin. The dose effect multiplier was between 1.7 and 5.1 times the administered dose. I put my rapamycin in an enteric coated (stomach passing) capsule and will combine it with piperine at my next dose. My dose calculations are very different than the ones described here:
The mice that live 60% longer when given 126 ppm enteric coated rapamycin took it for 6 months, that is about the same as a human taking rapamycin for 7 years. I do not have the calculations immediately in front of me, but with the mouse compensation factor, and the way mice eat 5 grams of food a day for just a 25-30g body mass, worked out to 89 mg/24 hours. That is orders of magnitude higher than the 5 mg dose (.71 mg/24 hours) mentioned here. I take 45 mg/24 hours with lipid rich food, and may take 45mg with piperine very 24 hours until/unless I notice unintended effects.
The big 5 mg to 89 mg dose difference could be ascribable to rapmycin also having a published longevity effect at 14 ppm, nine times less rapamycin/24 hours than the 60% longevity dose.
A 26 mg/24 hours dose with piperine at the 1.7 times dose multiplier could be similar, but of course an enteric capsule differs from a nanoparticle or an enteric coated version.
I do not have references, but I perceive I read (pubmed) humans on rapamycin experienced 20% less illness (I seem to remember colds and flu) even though rapamycin affects the immune system. I perceive I may have read that the 126 ppm at mouse food study may have also measured 20% more frequent head lifting and look around motions, and heightened performance on a water maze test. I may or may not have noticed a nootropic effect from 45 mg dose at an enteric capsule. If I notice there is a nootropic effect from the piperine with 45 mg/24 hours dose I might describe that here as a suggestion that the absorption increase from piperine is effective at enteric capsules.
To find the $45/gram rapamycin at alibaba.com I used their get a quote (RFQ) function that shows up when you search an item (rapamycin), click on an item, and then see a RFQ making textarea; after a few days a person sent me the $45/g option.
At the $45/gram at perhaps a 5 gram alibaba quantity amount, 45 mg is 40 cents every 24 hours, at the 26 mg dose with piperine it is 23 cents/24 hours. I actually got the $90/g rapamycin on my first order, so now I know what it tastes like so I can perceive if the $45/g material is actually also rapamycin.
I will see if I can duplicate the 126 ppm at food being 89 mg/24 hour human dose:
126 ppm is 126 mg/Kg of food, there is a mouse surface area (possibly metabolism) adjustment where you divide mouse doses with 12.6 to find a human dose. That makes a human dose at 500 grams of food/24 hours at: 10 mg/24 hours, notably though mice eat 5/30ths their mass in food every 24 hours so the dose the mice actually ingested from eating 23.8 times more food was was the equivalent of 238 mg of rapamycin/24 hours at a human being. That number is much higher than the 89/mg/24 hours amount, and I do not know why the numbers are different. Perhaps someone here would like to make a new, more accurate human dose calculation.
Also it is my perception that mice eat frequently many times during a 24 hour interval, and that a human would benefit from taking two or more divided doses a day, so two 119 mg rapamycin with piperine capsules a day. I perceive I read that mice given an IP injection once every 24 hours experienced something I perceive as about half the longevity increase as continuous nibbling at food, so that is perhaps a thought.
Also, I read two different values for the plasma half life of rapamycin at humans. I perceive I read one at pubmed that said .9 hours, and another at the wikipedia page for rapamycin that said 56 hours. If the plasma half life is actually 56 hours then the two pills a day rapamycin with piperine dose could have stronger equivalence of function to the mouse ad libitum food plasma levels.
An optimist though might like to think that the 5.1 times piperine multiplier works on the 45 mg/24 hours rapamycin dose, if so, then that is the equivalent of 229 mg rapamycin/24 hours. Upping that to a 1.7 piperine multiplier at 140 mg/24 hours of rapamycin, makes the rapamycin $1.24 each 24 hours at a human dose.
It looks like a 140 mg/24 hours with a few hundred milligrams of piperine at an enteric (stomach passing) capsule could be a human equivalent dose to the 126 ppm dose at mouse food 60% longevity increase dose.
Rather than just go with these numbers I urge you to make a new dose calculation and describe it here, notably at the 126 ppm food, 60% longevity dose.
There are some other ideas about a rapamycin dose: an upper limit on a dose benefit has not been published, so it is possible that more than 126 ppm at food could actually cause greater than 60% longevity, that supports a piperine multiplier causing a higher equivalent dose so long as the human is absent any unintended effects.
Edited by treonsverdery, 31 August 2019 - 02:38 AM.