9 replies to this topic

[Phoebus]

This thread is for discussing CD38 inhibitors and their ability to help maintain NAD levels. 

[Phoebus]

Michael Lustgarten recently posted this video and it has some great info in it. Now up to now I always thought apigenin was the most potent CD38 inhibitor. But he has data in this video which shows luteolin, luteolindin, and kuromanin (better known as Cyanidin) are all actually much more potent in this regard. Watch from about 1 minute on

 

 

If we go to phenol explorere we find that the food highest in cyanidin is black elderberry, and I mean it has literally hundreds of time more of it than almost all other foods. 

 

http://phenol-explor...ts/polyphenol/9

 

This would indicate elderberry is an extremely strong CD38 inhibitor, MUCH stronger than say strawberries which contain a much much lower amount of apigenin. 

 

Edited by Phoebus, 11 June 2021 - 01:06 AM.

[Phoebus]

As for apigenin, the best food source by far and away is chamomile coming in at 5,000 mg/100 grams 

 

No other food even comes close 

 

https://watermark.si...1a4NUS_UEsEhVKg

[Phoebus]

Apigenin is insolluble in water, so chamomille tea is a terrible source for apigenin since none of it is getting into the water. 

 

I can't find any info on whether it is fat/lipid soluble however. It is soluble in alcohol however. So maybe a strong alcoholic chamomile tincture might be a good source of apigenin. 

[Harkijn]

Also take a look here:

https://www.longecit...ry-of-apigenin/

[Phoebus]

Right now there is not a single apigenin product available on amazon or anywhere else that I can see. 

 

If someone sees one, please link it. 

[pamojja]

https://www.swansonv...n-50-mg-90-caps

 

However, as the former posts also points out, it is too easy to get 45mg of Apigenin by ingesting 1g of dried Parsley only.

[Phoebus]

That Swanson product is out of stock, just like everywhere else. I am alergic to parsely, so I guess chamomile is my best bet 

[koffea]

I have bought apigenin from here:

 

https://donotage.org.../pure-apigenin/

 

I have been taking 500 mg a day for about a month.  The only thing that I think I can say is that it appeared to elevate my BP enough to give me headaches. 

[Gal220]

Thorne includes both Resveratrol and Quercetin in its NR formula, Quercetin recycles Resveratrol. - LINK

 

Quercetin Phytosome

Senescence is the natural process in which aging cells stop dividing, but do not die. The over-accumulation of senescent cells is associated with biological aging and various age-related disorders. Quercetin is at the forefront of healthy aging because:

• Quercetin is one of only two nutrients that have been studied for its ability to reduce cellular senescence*
• Quercetin partners with resveratrol in the quest for healthy aging because it slows the breakdown of resveratrol in the body, allowing resveratrol more time to do its job*
• Quercetin up-regulates the sirtuin proteins, which are associated with healthy cellular aging and improved weight-related metabolic factors*

Edited by Gal220, 05 July 2021 - 10:20 PM.