edit: I left a gap between the 300-400 and 500-600... changing pole to remove gap (will not affect data so far)
Edited by edward, 08 February 2008 - 04:14 AM.
Posted 07 February 2008 - 10:29 PM
Edited by edward, 08 February 2008 - 04:14 AM.
Posted 07 February 2008 - 10:30 PM
Posted 07 February 2008 - 10:31 PM
oops, after I voted I realize I do get a small amount from my ortho core.
Posted 08 February 2008 - 03:22 AM
Posted 08 February 2008 - 04:12 AM
I take 450mg
Posted 08 February 2008 - 05:39 AM
oops, after I voted I realize I do get a small amount from my ortho core.
Lol, you must like voting in polls
Posted 08 February 2008 - 02:16 PM
Posted 22 February 2008 - 07:50 PM
Posted 11 December 2008 - 04:43 PM
Posted 11 December 2008 - 05:14 PM
Posted 12 December 2008 - 10:48 PM
I'm taking 600 mg of NAC (i.e., N-acetyl-L-cysteine) on Monday and Friday for a total of 1200 mg per week. I use the Solgar brand.
Edited by zorba990, 12 December 2008 - 11:18 PM.
Posted 26 January 2009 - 05:52 PM
I'm taking 600 mg of NAC (i.e., N-acetyl-L-cysteine) on Monday and Friday for a total of 1200 mg per week. I use the Solgar brand.
Still taking 2400mg a day. No problems.
Re: "The heart enlargement artrey narrowing effects confirm my lack of enthusiasm."
Has this really been confirmed in humans? Have there been any reported cases of such effects?
My understanding is that the rat study used
10mg/ml of water for a total approximate intake of 300mg per day. If I go by
Ray Sahelian's measurements here (and I think he overestimates mouse weight):
http://www.raysaheli...ylcysteine.html
that works out to 448,000 mg of NAC per day!
Hardly in the same ballpark as 2400mg or any other reasonable dose.
Posted 26 January 2009 - 10:27 PM
Posted 27 January 2009 - 05:12 AM
I'm taking 600 mg of NAC (i.e., N-acetyl-L-cysteine) on Monday and Friday for a total of 1200 mg per week. I use the Solgar brand.
Still taking 2400mg a day. No problems.
Re: "The heart enlargement artrey narrowing effects confirm my lack of enthusiasm."
Has this really been confirmed in humans? Have there been any reported cases of such effects?
My understanding is that the rat study used
10mg/ml of water for a total approximate intake of 300mg per day. If I go by
Ray Sahelian's measurements here (and I think he overestimates mouse weight):
http://www.raysaheli...ylcysteine.html
that works out to 448,000 mg of NAC per day!
Hardly in the same ballpark as 2400mg or any other reasonable dose.
Has there ever, in the extensive history of human NAC supplementation and use by mainstream medicine as a drug to treat and prevent liver toxicity, renal toxicity, etc, been a single reported case of NAC-induced PAH in humans? Ever? Because I feel like a great disservice has been done to this noble nutrient, and a mountain of positive literature and human clinical evidence has been undermined by a single extreme overdose study in mice.
Please tell me I'm wrong.
Posted 27 January 2009 - 05:25 AM
Posted 14 February 2009 - 12:24 PM
I'm taking 600 mg of NAC (i.e., N-acetyl-L-cysteine) on Monday and Friday for a total of 1200 mg per week. I use the Solgar brand.
Still taking 2400mg a day. No problems.
Re: "The heart enlargement artrey narrowing effects confirm my lack of enthusiasm."
Has this really been confirmed in humans? Have there been any reported cases of such effects?
My understanding is that the rat study used
10mg/ml of water for a total approximate intake of 300mg per day. If I go by
Ray Sahelian's measurements here (and I think he overestimates mouse weight):
http://www.raysaheli...ylcysteine.html
that works out to 448,000 mg of NAC per day!
Hardly in the same ballpark as 2400mg or any other reasonable dose.
Has there ever, in the extensive history of human NAC supplementation and use by mainstream medicine as a drug to treat and prevent liver toxicity, renal toxicity, etc, been a single reported case of NAC-induced PAH in humans? Ever? Because I feel like a great disservice has been done to this noble nutrient, and a mountain of positive literature and human clinical evidence has been undermined by a single extreme overdose study in mice.
Please tell me I'm wrong.
do we know it would have been attributed to the NAC? lots of toxins didn't get connected to their effects for a long time.
Posted 15 February 2009 - 07:11 AM
StephenBToxins A and B from the anaerobic bacterium Clostridium difficile are the causative agents of the antibiotic-associated pseudomembraneous colitis. At the subcellular level, they inhibit the Rho family GTPases, thus causing alterations of the actin cytoskeleton. The cytoskeletal integrity is also controlled by the redox state of cells. Therefore, we have evaluated whether an oxidative imbalance could be involved in the toxin-induced cytopathic effects. Our results indicate that both toxins induce oxidative stress with a significant depletion of protein SH-groups. These responses and the cytoskeleton-dependent cell retraction and rounding are significantly counteracted by N-acetylcysteine but not by alpha-tocopherol. Our study provides the first evidence that the thiol supplier N-acetylcysteine impairs the cellular intoxication by acting on the cytoskeleton integrity. This also suggests a possible beneficial role for this drug during therapeutic intervention.
Posted 20 February 2009 - 09:42 PM
Posted 05 March 2009 - 06:00 PM
Posted 19 March 2009 - 04:26 AM
600 mg/day increases hypoxic ventilatory response in humans, which is step one on the road to PAH.We would know if a case report existed linking NAC to PAH in humans because it would be stated it explicitly in the case report. So the question remains, in the extensive history of human dietary supplementation with NAC, and in the extensive history of NAC's use as a prescription drug by mainstream medicine, has there ever been a single (one, 1) report of NAC causing PAH?
Posted 19 March 2009 - 04:34 AM
600 mg/day increases hypoxic ventilatory response in humans, which is step one on the road to PAH.We would know if a case report existed linking NAC to PAH in humans because it would be stated it explicitly in the case report. So the question remains, in the extensive history of human dietary supplementation with NAC, and in the extensive history of NAC's use as a prescription drug by mainstream medicine, has there ever been a single (one, 1) report of NAC causing PAH?
http://bloodjournal..../full/99/5/1552
Posted 19 March 2009 - 05:08 AM
600 mg/day increases hypoxic ventilatory response in humans, which is step one on the road to PAH.We would know if a case report existed linking NAC to PAH in humans because it would be stated it explicitly in the case report. So the question remains, in the extensive history of human dietary supplementation with NAC, and in the extensive history of NAC's use as a prescription drug by mainstream medicine, has there ever been a single (one, 1) report of NAC causing PAH?
http://bloodjournal..../full/99/5/1552
Posted 19 March 2009 - 10:51 PM
Posted 19 March 2009 - 11:36 PM
Posted 19 May 2009 - 03:18 AM
Posted 20 May 2009 - 12:07 AM
Edited by nancyd, 20 May 2009 - 12:09 AM.
Posted 20 May 2009 - 10:51 PM
Edited by Lufega, 20 May 2009 - 10:53 PM.
Posted 21 May 2009 - 04:14 AM
600 mg/day increases hypoxic ventilatory response in humans, which is step one on the road to PAH.
Posted 21 May 2009 - 03:23 PM
Just got back my AST/ALT and they are almost in the lower range.
Posted 18 December 2009 - 04:09 PM
Yeah, fuck it. I drink so much that PAH is much lower on my list of concerns than cirrhosis. I take 600 mg every time I drink. Along with milk thistle, SAM-e, ALA, curcumin, and a shit load of other hepatoprotectives. I'll let you know when and if my ALT/AST are ever out of range.
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